Nature Reviews Molecular Cell Biology contents November 2014 Volume 15 Number 11 pp 699-760

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TABLE OF CONTENTS
November 2014 Volume 15 Number 11
Impact Factor 36.458 *	In this issue Research Highlights Addendum Progress Reviews Analysis Also this month  Featured article: Signalling dynamics in the spindle checkpoint response Nitobe London & Sue Biggins
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RESEARCH HIGHLIGHTS Top Epigenetics: Enhancers under TET control p699 | doi:10.1038/nrm3901 The ten-eleven-tanslocation (TET) family of proteins regulates enhancer methylation and activity in embryonic stem cells. PDF In the news p700 | doi:10.1038/nrm3886 Kazutoshi Mori and Peter Walter were awarded the 2014 Albert Lasker Basic Medical Research Award for their discoveries on the unfolded protein response. PDF Protein quality control: Nuclear membrane proteins in check p700 | doi:10.1038/nrm3898 The Asi complex defines an ERAD branch that is specific for inner nuclear membrane protein quality control in yeast. PDF Metabolism: Fat cadherins regulate mitochondrial function p702 | doi:10.1038/nrm3892 Fat cadherins are required for the function of the electron transport chain. PDF Cell adhesion: Winning mechanism for angiogenesis p702 | doi:10.1038/nrm3893 Angiogenic factors induce podosome rosettes in endothelial cells that mediate focal degradation of the basement membrane and blood vessel branching. PDF IN BRIEF Cell signalling: A RAG dissociation inhibitor | Technology: RNA targeting by Cas9 PDF Molecular Cell Biology JOBS of the week Postdoctoral Research Associate University of Wisconsin School of Medicine and Public Health Post-Doctoral Fellow Northeast Ohio Medical University Postdoctoral position in Single-Cell Biology of the Nucleus Karolinska Institutet (KI) PhD Position University of Cologne Chairperson, Department of Cell Biology Rowan University More Science jobs from Molecular Cell Biology EVENT Plant Receptor Kinases: From Molecules to Environment 08.02.15 Taos, USA More science events from
ADDENDUM		Top
Cell death: RIPK1 protects epithelial cells Kim Baumann p701 | doi:10.1038/nrm3900 Full Text | PDF
PROGRESS		Top
Histone core modifications regulating nucleosome structure and dynamics Peter Tessarz & Tony Kouzarides p703 | doi:10.1038/nrm3890 Recent data suggest that histone modifications have a direct effect on nucleosomal architecture. Acetylation, methylation, phosphorylation and citrullination of the histone core may influence chromatin structure by affecting histone-histone and histone-DNA interactions, as well as the binding of histones to chaperones. Abstract | Full Text | PDF | Supplementary information
REVIEWS		Top
Signalling dynamics in vertebrate segmentation Alexis Hubaud & Olivier Pourquié p709 | doi:10.1038/nrm3891 Somite formation relies on a molecular oscillator, the segmentation clock, which leads to oscillatory gene expression in the presomitic mesoderm; this is converted into the periodic generation of segments in response to signalling gradients referred to as the wavefront. Recent studies provide insights into the molecular mechanisms behind this intricate developmental system. Abstract | Full Text | PDF
Chromatin dynamics in the regulation of cell fate allocation during early embryogenesis Adam Burton & Maria-Elena Torres-Padilla p723 | doi:10.1038/nrm3885 It is unclear how totipotent embryonic cells acquire their fate and what role chromatin dynamics have in this process. Technological advances in studying single cells have begun to improve our understanding of the mechanisms underlying lineage allocation and cell plasticity in early mammalian development. Abstract | Full Text | PDF
Signalling dynamics in the spindle checkpoint response Nitobe London & Sue Biggins p736 | doi:10.1038/nrm3888 The mechanisms underlying spindle checkpoint signalling at the kinetochore, which ensures faithful chromosome segregation during cell division, are being unravelled. They indicate that the checkpoint response is graded rather than switch-like (completely on or off) as traditionally thought, and provide insights for the treatment of cancers in which the checkpoint is bypassed. Abstract | Full Text | PDF
ANALYSIS		Top
The structure, function and evolution of proteins that bind DNA and RNA William H. Hudson & Eric A. Ortlund p749 | doi:10.1038/nrm3884 Binding of DNA and of RNA are no longer considered functionally distinct, partly owing to the discovery that DNA- and RNA-binding proteins (DRBPs) can bind long non-coding RNAs and DNA. The unique functional characteristics of DRBPs stem from their specific structural features and allow them to regulate various cellular processes. Abstract | Full Text | PDF | Supplementary information
Erratum: Capping protein regulators fine-tune actin assembly dynamics Marc Edwards, Adam Zwolak, Dorothy A. Schafer, David Sept, Roberto Dominguez & John A. Cooper p760 | doi:10.1038/nrm3887 Full Text | PDF
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