Nature Reviews Microbiology contents November 2014 Volume 12 Number 11 pp 724-787

TABLE OF CONTENTS
November 2014 Volume 12 Number 11
Impact Factor 23.317 *	In this issue Research Highlights News and Analysis Progress Reviews Perspectives Also this month Article series: Microbiology pioneers Poster: CRISPR–Cas: extraordinary editing  Featured article: Revealing a world of biofilms — the pioneering research of Bill Costerton Hilary Lappin-Scott, Sara Burton & Paul Stoodley
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RESEARCH HIGHLIGHTS Top Viral infection: KSHV flicks the metabolic switch p723 | doi:10.1038/nrmicro3377 Yogev et al. show that KSHV-encoded miRNAs induce the Warburg effect in latently infected cells and that it is important to maintain viral latency. PDF Bacterial physiology: Streptomyces teams up with c-di-GMP p724 | doi:10.1038/nrmicro3361 A new study shows that a unique tetrameric form of c-di-GMP controls development in Streptomyces venezuelae by mediating dimerization of a transcription factor. PDF Antimicrobials: The benefits of cycling p724 | doi:10.1038/nrmicro3370 A new study shows how alternating antibiotics reduces the evolution of multidrug resistance. PDF Microbiome: Commensally sourced antibiotics p726 | doi:10.1038/nrmicro3363 A new study analyses the distribution of biosynthetic gene clusters in the human microbiome and finds a novel bacterial thiopeptide with antibacterial properties. PDF Bacterial pathogenesis: First aid kit for cholera p726 | doi:10.1038/nrmicro3366 A new study investigates the role of the human gut microbiota in Vibrio cholerae infection and shows that Ruminococcus obeum decreases the expression of V. cholerae virulence factors to limit colonization. PDF IN BRIEF Bacterial pathogenesis: A pneumococcal heart-breaker | Bacterial genetics: Chromosomal position regulates gene expression | Viral infection: Host and viral components of the influenza virion | Marine microbiology: Exploring the unexplored | Microbial ecology: Inter-kingdom interactions | Microbiome: Bacteria and the brain PDF Microbiology JOBS of the week Four-Five Full Microbiology Professor Positions Nanjing Medical University Research group leader position in Molecular and Cellular Microbiology Max Planck Institute for Terrestrial Microbiology Postdoctoral Fellow Department of Veterans Affairs Medical Center Post-Doctoral Position in Microalgal Biology CEA French Atomic and Alternative Energies Commission Postdoctoral Scientist Seattle Biomedical Research Institute More Science jobs from Microbiology EVENT More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Genomics illuminates parasite biology Bernardo J. Foth & Thomas D. Otto p727 | doi:10.1038/nrmicro3368 This month's Genome Watch highlights recent examples of the major contributions that genomics has made to new biological discoveries in malaria parasites. PDF
PROGRESS		Top
Nitrogen metabolism in Mycobacterium tuberculosis physiology and virulence Alexandre Gouzy, Yannick Poquet & Olivier Neyrolles p729 | doi:10.1038/nrmicro3349 The crosstalk between the metabolic pathways of intracellular pathogens and host cells can have important consequences for infection. In this Progress article, Neyrolles and colleagues describe recent insights into nitrogen acquisition and assimilation in Mycobacterium tuberculosis and highlight potential links to bacterial virulence. Abstract | Full Text | PDF
REVIEWS		Top
The sweet spot: defining virus-sialic acid interactions Jennifer E. Stencel-Baerenwald, Kerstin Reiss, Dirk M. Reiter, Thilo Stehle & Terence S. Dermody p739 | doi:10.1038/nrmicro3346 Viral infection is induced by binding of the virus to host sialylated glycans on the cell surface. Glycan array studies and structure determination provide new insights into the virus-silaic acid interaction and its functional role in viral disease. This Review highlights principles of glycan binding that are used by influenza virus, reovirus, adenovirus and rotavirus. Abstract | Full Text | PDF
Eradicating HIV-1 infection: seeking to clear a persistent pathogen Nancie M. Archin, Julia Marsh Sung, Carolina Garrido, Natalia Soriano-Sarabia & David M. Margolis p750 | doi:10.1038/nrmicro3352 Recent efforts have focused on the development of therapies that could eradicate HIV-1 infection or achieve a durable remission of viraemia in the absence of antiretroviral therapy; however, targeting viral quiescence within specific cellular reservoirs so that residual infection can be cleared remains a challenge. In this Review, Margolis and colleagues explore new approaches to eradicate established HIV-1 infection. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Novel vaccine vectors for HIV-1 Dan H. Barouch & Louis J. Picker p765 | doi:10.1038/nrmicro3360 In this Opinion article, Dan Barouch and Louis Picker discuss recent data regarding the clinical development of novel serotype adenovirus and cytomegalovirus vaccine vectors for use in HIV-1 vaccines. Abstract | Full Text | PDF
OPINION A mechanistic theory to explain the efficacy of antiretroviral therapy Sarah B. Laskey & Robert F. Siliciano p772 | doi:10.1038/nrmicro3351 Combination antiretroviral therapy (cART) has revolutionized the treatment of HIV-1 infection, but the mechanistic basis of successful treatment is poorly understood. In this Opinion article, Siliciano and Laskey present a model to assess the efficacy of antiretroviral drugs and argue that this is a more accurate metric to predict the success of cART than current metrics. Abstract | Full Text | PDF
ESSAY Article series: Microbiology pioneers Revealing a world of biofilms — the pioneering research of Bill Costerton Hilary Lappin-Scott, Sara Burton & Paul Stoodley p781 | doi:10.1038/nrmicro3343 In this Essay in our Microbiology Pioneers series, Hilary Lappin-Scott, Sara Burton and Paul Stoodley pay tribute to Bill Costerton, who was the founding father of biofilm research, and trace his development of the biofilm concept. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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