The EMBO Journal Table of Contents for 17 September 2014; Vol. 33, No. 18

17 September 2014 | Volume 33, Number 18 Submit Table of Contents Have you seen? Review Articles Corrigendum Volume 33, Number 18 Have you seen? Primary piRNA biogenesis: caught up in a Maelstrom In pachytene spermatids, piRNA biogenesis depends on Maelstrom, a nucleo‐cytoplasmic shuttling protein and component of nuage granules. Generally, mammalian piRNAs target transposable elements, but in the male germline, acrosome and flagella formation are piRNA‐dependent. Radha Raman Pandey and Ramesh S Pillai Published online 22.08.2014 tRNAs: new tricks from old dogs Novel results on tRNAs reveal regulatory contributions of tRNA fragments for the integrity of the developing brain. A related study unravels the intimate coordination of tRNA expression and cellular demands for mRNA translation. Georg Stoecklin and Sven Diederichs Published online 12.09.2014 Sox2, a marker for stem‐like tumor cells in skin squamous cell carcinoma and hedgehog subgroup medulloblastoma The identification of Sox2 as cancer stem‐cell marker and driver of cancer stemness in distinct tumor types suggests that each tumor resembles the hierarchical organization of the tissue from which it arises. Oren J Becher and Eric C Holland Published online 24.07.2014 Review Focus: Molecular Memory: Epigenetic memory in plants Review series on Molecular Memory: epigenetic modifications shape development, adaptation and cellular memory in plants. Mayumi Iwasaki and Jerzy Paszkowski Published online 07.08.2014 Articles Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice Loss of piRNA biogenesis factor Maelstrom leads to flagellum malformation and aberrant translational regulation, thus offering insight on a role for the elusive mammalian pachytene piRNAs. Julio Castañeda, Pavol Genzor, Godfried W van der Heijden, Ali Sarkeshik, John R Yates III, Nicholas T Ingolia, and Alex Bortvin Published online 25.07.2014 Aberrant methylation of tRNAs links cellular stress to neuro‐developmental disorders This study causally links post‐transcriptional methylation‐controlled tRNA identity and their stability to neurological disorders in human. Sandra Blanco, Sabine Dietmann, Joana V Flores, Shobbir Hussain, Claudia Kutter, Peter Humphreys, Margus Lukk, Patrick Lombard, Lucas Treps, Martyna Popis, Stefanie Kellner, Sabine M Hölter, Lillian Garrett, Wolfgang Wurst, Lore Becker, Thomas Klopstock, Helmut Fuchs, Valerie Gailus‐Durner, Martin Hrabĕ de Angelis, Ragnhildur T Káradóttir, Mark Helm, Jernej Ule, Joseph G Gleeson, Duncan T Odom, and Michaela Frye Published online 25.07.2014 Genome‐wide identification of miR‐200 targets reveals a regulatory network controlling cell invasion miR‐200 microRNAs are involved in the maintenance of epithelial integrity. Direct, transcriptome‐wide target detection and validation identifies genes functionally grouped as regulators of Rho GTPase signaling, invadopodia formation, metalloprotease activity and cell adhesion, which together regulate cell motility, migration and cancer metastasis. Cameron P Bracken, Xiaochun Li, Josephine A Wright, David M Lawrence, Katherine A Pillman, Marika Salmanidis, Matthew A Anderson, B Kate Dredge, Philip A Gregory, Anna Tsykin, Corine Neilsen, Daniel W Thomson, Andrew G Bert, Joanne M Leerberg, Alpha S Yap, Kirk B Jensen, Yeesim Khew‐Goodall, and Gregory J Goodall Published online 28.07.2014 Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67‐RFP allele A Ki67‐RFP knock‐in allele highlights the heterogeneity of Lgr5+ stem‐ and progenitor cells based on in vivo cell cycle profiles. Onur Basak, Maaike van de Born, Jeroen Korving, Joep Beumer, Stefan van der Elst, Johan H van Es, and Hans Clevers Published online 04.08.2014 Negative control of BAK1 by protein phosphatase 2A during plant innate immunity Protein phosphatase PP2A negatively regulates the kinase BAK1 to fine tune innate immunity signaling in plants via pathogen recognition receptors FLS2 and EFR. Cécile Segonzac, Alberto P Macho, Maite Sanmartín, Vardis Ntoukakis, José Juan Sánchez‐Serrano, and Cyril Zipfel Published online 01.08.2014 A positive signal prevents secretory membrane cargo from recycling between the Golgi and the ER Plasma membrane (PM)‐targeted proteins cycle back and forth between ER and Golgi. Proteins equipped with a polypeptide export signature escape the Rab6‐regulated retrograde pathway more easily, reaching the PM faster. Matteo Fossati, Sara F Colombo, and Nica Borgese Published online 25.07.2014 Regulation of cargo‐selective endocytosis by dynamin 2 GTPase‐activating protein girdin The actin binding protein girdin is a GAP for dynamin 2. Girdin regulates clathrin‐dependent endocytosis through a non‐canonical mechanism that involves competition between dynamin 2 and certain cargos for girdin binding, resulting in spatial control of protein internalization. Liang Weng, Atsushi Enomoto, Hiroshi Miyoshi, Kiyofumi Takahashi, Naoya Asai, Nobuhiro Morone, Ping Jiang, Jian An, Takuya Kato, Keisuke Kuroda, Takashi Watanabe, Masato Asai, Maki Ishida‐Takagishi, Yoshiki Murakumo, Hideki Nakashima, Kozo Kaibuchi, and Masahide Takahashi Published online 24.07.2014 A conformational switch in collybistin determines the differentiation of inhibitory postsynapses Structural and functional data show that the adhesion protein neuroligin‐2 stabilizes the open, active conformation of the adaptor collybistin, thus regulating gephyrin and GABAA receptor clustering at postsynaptic membranes. Tolga Soykan, Daniela Schneeberger, Giancarlo Tria, Claudia Buechner, Nicole Bader, Dmitri Svergun, Ingrid Tessmer, Alexandros Poulopoulos, Theofilos Papadopoulos, Frédérique Varoqueaux, Hermann Schindelin, and Nils Brose Published online 30.07.2014 Corrigendum Genome‐wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co‐activation Alessandro Gardini, David Baillat, Matteo Cesaroni, and Ramin Shiekhattar Published online 17.09.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.