Nature Communications - 3 September 2014

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Weekly Content Alert 03 September 2014  Featured image: Twomey et al. show that mimicry may drive speciation in frogs. Latest content: Articles Journal homepage Recommend to library Web feed     Latest Articles View all Articles     An engineered pathway for the biosynthesis of renewable propane Pauli Kallio, András Pásztor, Kati Thiel, M. Kalim Akhtar and Patrik R. Jones Propane is the main component of liquid petroleum gas and has a wide variety of commercial applications. Here, the authors engineer a synthetic metabolic pathway in E. coli, and demonstrate for the first time the renewable production of propane. 02 September 2014 | doi: 10.1038/ncomms5731 Biological Sciences  Bioengineering  Biotechnology  Weakening of the stratospheric polar vortex by Arctic sea-ice loss Baek-Min Kim, Seok-Woo Son, Seung-Ki Min, Jee-Hoon Jeong, Seong-Joong Kim, Xiangdong Zhang, Taehyoun Shim and Jin-Ho Yoon The mechanism behind the severely cold winters experienced by the mid-latitudes of the Northern Hemisphere in recent years is not fully understood. Here, the authors combine observational analyses and model experiments to reveal a dynamic connection between Arctic sea-ice cover and the polar stratosphere. 02 September 2014 | doi: 10.1038/ncomms5646 Earth Sciences  Atmospheric science  Climate science  Terrestrial selenium distribution in China is potentially linked to monsoonal climate Tim Blazina, Youbin Sun, Andreas Voegelin, Markus Lenz, Michael Berg and Lenny H.E. Winkel Selenium deficiency is a major health problem, particularly in the selenium-poor belt in China, yet its distribution in the terrestrial environment is poorly understood. Here, the authors combine geochemical and palaeoclimate data and show that selenium distribution in China may be related to East Asian monsoon rainfall. 02 September 2014 | doi: 10.1038/ncomms5717 Earth Sciences  Atmospheric science  Climate science  Hierarchical synthesis of non-centrosymmetric hybrid nanostructures and enabled plasmon-driven photocatalysis Lin Weng, Hui Zhang, Alexander O. Govorov and Min Ouyang The continued development of hybrid nanostructures is important for a range of applications. Here, the authors fabricate non-centrosymmetric hybrid nanostructures of programmable composition, and demonstrate that they are capable of plasmon enhanced photocatalysis. 02 September 2014 | doi: 10.1038/ncomms5792 Chemical Sciences  Inorganic chemistry  Materials science  Nanotechnology  Physical autocatalysis driven by a bond-forming thiol–ene reaction Andrew J. Bissette, Barbara Odell and Stephen P. Fletcher Autocatalysis is a process whereby a product accelerates its own formation. Here, the authors describe a system whereby two simple components combine irreversibly to give a more complex, amphiphilic product, leading to autocatalytically active micelles. 02 September 2014 | doi: 10.1038/ncomms5607 Chemical Sciences  Catalysis  Organic chemistry  Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs Joanne L. Fothergill, Daniel R. Neill, Nick Loman, Craig Winstanley and Aras Kadioglu Pseudomonas aeruginosa causes chronic infections in patients with lung damage. Here, Fothergill et al. develop an intranasal inhalation model of P. aeruginosa infection and describe genetic and phenotypic changes that the bacteria undergo during adaptation and spread through the respiratory tract. 02 September 2014 | doi: 10.1038/ncomms5780 Biological Sciences  Microbiology  Near-field interferometry of a free-falling nanoparticle from a point-like source James Bateman, Stefan Nimmrichter, Klaus Hornberger and Hendrik Ulbricht Testing the validity of the quantum superposition principle with increasingly large particles may shed light on the quantum to classical transition for macroscopic objects. Here, Bateman et al. propose a near-field interference scheme based on the single-source Talbot effect for 106 amu silicon particles. 02 September 2014 | doi: 10.1038/ncomms5788 Physical Sciences  Atomic and molecular physics  Theoretical physics  Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice Sang H. Min, Aae Suzuki, Timothy J. Stalker, Liang Zhao, Yuhuan Wang, Chris McKennan, Matthew J. Riese, Jessica F. Guzman, Suhong Zhang, Lurong Lian, Rohan Joshi, Ronghua Meng, Steven H. Seeholzer, John K. Choi, Gary Koretzky, Michael S. Marks and Charles S. Abrams PIKfyve is a lipid kinase essential for regulation of membrane homeostasis and vesicle trafficking along the endosomal-lysosomal pathway. Here the authors show that mice lacking PIKfyve exclusively in their platelets exhibit a systemic disorder characterized by multi-organ inflammation and thrombosis due to aberrant platelet lysosome function. 02 September 2014 | doi: 10.1038/ncomms5691 Biological Sciences  Medical research  Efficient photoelectrochemical hydrogen production from bismuth vanadate-decorated tungsten trioxide helix nanostructures Xinjian Shi, Il Yong Choi, Kan Zhang, Jeong Kwon, Dong Yeong Kim, Ja Kyung Lee, Sang Ho Oh, Jong Kyu Kim and Jong Hyeok Park There is significant research into new composite catalysts for photoelectrochemical water splitting. Here, the authors report a helical bismuth vanadate/tungsten trioxide heterojunction array and show that its structural features yield high photocurrents. 02 September 2014 | doi: 10.1038/ncomms5775 Chemical Sciences  Catalysis  Materials science  4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation OPEN Cátia Igreja, Daniel Peter, Catrin Weiler and Elisa Izaurralde eIF4E-binding proteins (4E-BPs) are a conserved class of translational repressors that play essential roles in the regulation of protein expression. Here, Igreja et al. indentify non-canonical interactions between 4E-BPs and eIF4E that are required to effectively displace eIF4G and inhibit translation. 02 September 2014 | doi: 10.1038/ncomms5790 Biological Sciences  Molecular biology  Single yeast cells vary in transcription activity not in delay time after a metabolic shift Anne Schwabe and Frank J. Bruggeman Individual cells respond differently to environmental stressors. Here, Schwabe et al. expose yeast cells to sulphur stress and show that small variations in response time combined with a high transient variability in transcript number contribute to stochasticity in response to this stress. 02 September 2014 | doi: 10.1038/ncomms5798 Biological Sciences  Cell biology  Microbiology  TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour OPEN Amanda S. Lindy, Puja K. Parekh, Richard Zhu, Patrick Kanju, Sree V. Chintapalli, Volodymyr Tsvilovskyy, Randen L. Patterson, Andriy Anishkin, Damian B. van Rossum and Wolfgang B. Liedtke TRPs are calcium-permeable channels involved in the sensing of damaging stimuli but the relationship between calcium influx and pain behaviour has been elusive. Here the authors find that the TRP channel OSM-9 functions as an ion channel in vivo in C. elegans, and establish residues that are critical for worm pain-like behaviour. 02 September 2014 | doi: 10.1038/ncomms5734 Biological Sciences  Neuroscience  The contribution of frequency-specific activity to hierarchical information processing in the human auditory cortex OPEN L. Fontolan, B. Morillon, C. Liegeois-Chauvel and Anne-Lise Giraud Sensory processing relies on information transfer in cortical hierarchies. Using depth recordings of neural activity obtained while individuals with epilepsy listen to spoken sentences, the authors show that ascending and descending information is propagated between cortical regions through distinct neural frequencies. 02 September 2014 | doi: 10.1038/ncomms5694 Biological Sciences  Neuroscience  Broadband optical cooling of molecular rotors from room temperature to the ground state Chien-Yu Lien, Christopher M Seck, Yen-Wei Lin, Jason H.V. Nguyen, David A. Tabor and Brian C. Odom Laser cooling of atoms is now routine, but cooling molecules is more difficult due to the larger number of transition frequencies involved. Here, the authors show that a broadband laser can be used to provide cooling of a molecule into its ground rotational-vibrational state. 02 September 2014 | doi: 10.1038/ncomms5783 Physical Sciences  Atomic and molecular physics  Optical physics  Selective metal deposition at graphene line defects by atomic layer deposition Kwanpyo Kim, Han-Bo-Ram Lee, Richard W. Johnson, Jukka T. Tanskanen, Nan Liu, Myung-Gil Kim, Changhyun Pang, Chiyui Ahn, Stacey F. Bent and Zhenan Bao Defects in graphene strongly influence the material's physical properties, leading to the suggestion that defects might be tuned to improve performance. Here, via atomic layer deposition, the authors selectively deposit Pt at grapheme line defects and yield a superior platform for sensing applications. 02 September 2014 | doi: 10.1038/ncomms5781 Physical Sciences  Materials science  Nanotechnology  Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis Esak Lee, Elana J. Fertig, Kideok Jin, Saraswati Sukumar, Niranjan B. Pandey and Aleksander S. Popel Metastases are known to preferentially spread through the lymphatic vessels. Here the authors uncover a self-reinforcing paracrine loop between breast cancer cells and lymphatic endothelial cells, which promotes seeding of cancer cells and angiogenesis in pre-metastatic niches but can be effectively blocked by repurposed therapeutic agents. 02 September 2014 | doi: 10.1038/ncomms5715 Biological Sciences  Cancer  A general and scalable synthesis approach to porous graphene Ding Zhou, Yi Cui, Pei-Wen Xiao, Mei-Yang Jiang and Bao-Hang Han Scalable routes towards porous graphene are useful for developing materials for mass transfer applications. Here, the authors report the fabrication of porous graphene with controllable pore size and nitrogen content via the carbothermal reaction of graphene and (poly)oxometallates. 02 September 2014 | doi: 10.1038/ncomms5716 Chemical Sciences  Materials science  Site-specific mapping and quantification of protein S-sulphenylation in cells Jing Yang, Vinayak Gupta, Kate S. Carroll and Daniel C. Liebler Cysteine S-sulphenylation provides redox regulation of protein functions, but the extent of this post-translational modification in cells is unknown. Here, Yang et al. develop a method to detect hundreds of S-sulphenylation sites in cells, and show that many of them respond to a physiologically relevant redox stimulus. 01 September 2014 | doi: 10.1038/ncomms5776 Biological Sciences  Biochemistry  Chemical biology  A robust SNP barcode for typing Mycobacterium tuberculosis complex strains OPEN Francesc Coll, Ruth McNerney, José Afonso Guerra-Assunção, Judith R. Glynn, João Perdigão, Miguel Viveiros, Isabel Portugal, Arnab Pain, Nigel Martin and Taane G. Clark Genetic variation in Mycobacterium tuberculosis complex (MTBC) bacteria is responsible for differences in factors such as virulence and transmissibility. Here, the authors analyse the genomes of 1,601 MTBC isolates from diverse geographic locations and identify 62 SNPs that may be used to resolve lineages and sublineages of these strains. 01 September 2014 | doi: 10.1038/ncomms5812 Biological Sciences  Genetics  Microbiology  Guided and magnetic self-assembly of tunable magnetoceptive gels OPEN S. Tasoglu, C.H. Yu, H.I. Gungordu, S. Guven, T. Vural and U. Demirci Self-assembly of micrometre-sized building blocks into complex functional patterns provides a useful tool for tissue engineering applications. Here, Tasoglu et al. present a practical method to guide the assembly of magnetically tunable gels in a magnetic field without physical contact. 01 September 2014 | doi: 10.1038/ncomms5702 Physical Sciences  Bioengineering  Materials science  Magnetic properties of uncultivated magnetotactic bacteria and their contribution to a stratified estuary iron cycle A.P. Chen, V.M. Berounsky, M.K. Chan, M.G. Blackford, C. Cady, B.M. Moskowitz, P. Kraal, E.A. Lima, R.E. Kopp, G.R. Lumpkin, B.P. Weiss, P. Hesse and N.G.F. Vella Magnetotactic bacteria synthesize magnetite or greigite magnetosomes that, when fossilized, can serve as biomarkers of past ocean redox shifts. Here, Chen et al. show that these magnetosome types have very similar coercivity distributions, with implications for the analysis of sedimentary magnetic records. 01 September 2014 | doi: 10.1038/ncomms5797 Earth Sciences  Biogeochemistry  Geology and geophysics  Microbiology  Contribution of RNA polymerase concentration variation to protein expression noise Sora Yang, Seunghyeon Kim, Yu Rim Lim, Cheolhee Kim, Hyeong Jeon An, Ji-Hyun Kim, Jaeyoung Sung and Nam Ki Lee The quantitative relationship between the fluctuation of specific extrinsic and intrinsic factors, and stochastic fluctuations in gene expression - or noise - has not been clearly established. Here, Yang et al. demonstrate that intrinsic noise is independent of - while extrinsic noise scales linearly with - variation in RNA polymerase abundance. 01 September 2014 | doi: 10.1038/ncomms5761 Biological Sciences  Systems biology  Giant spin Hall effect in graphene grown by chemical vapour deposition Jayakumar Balakrishnan, Gavin Kok Wai Koon, Ahmet Avsar, Yuda Ho, Jong Hak Lee, Manu Jaiswal, Seung-Jae Baeck, Jong-Hyun Ahn, Aires Ferreira, Miguel A. Cazalilla, Antonio H. Castro Neto and Barbaros Özyilmaz Manipulating spin currents in graphene by the spin–orbit interaction is important for many technological developments. Here, the authors show that the presence of residual metallic adatoms in chemical vapour deposition graphene enhances its spin–orbit coupling by three orders of magnitude. 01 September 2014 | doi: 10.1038/ncomms5748 Physical Sciences  Condensed matter  Materials science  TSC1 controls macrophage polarization to prevent inflammatory disease Linnan Zhu, Tao Yang, Longjie Li, Lina Sun, Yuzhu Hou, Xuelian Hu, Lianjun Zhang, Hongling Tian, Qingjie Zhao, Jianxia Peng, Hongbing Zhang, Ruoyu Wang, Zhongzhou Yang, Lianfeng Zhang and Yong Zhao Macrophages can be polarized to inflammatory M1 and anti-inflammatory M2 phenotypes, depending on the cytokine milieu. Here, Zhu et al. demonstrate that tuberous sclerosis complex 1 (TSC1) inhibits M1 and promotes M2 polarization of macrophages to prevent inflammatory disorders. 01 September 2014 | doi: 10.1038/ncomms5696 Biological Sciences  Immunology  Medical research  Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control OPEN Peng Dong, Manoj V. Maddali, Jaydeep K. Srimani, François Thélot, Joseph R. Nevins, Bernard Mathey-Prevot and Lingchong You The transcription factor E2F is critical for determining cell proliferation. By monitoring E2F activity in single cells throughout the cell cycle, Dong et al. provide evidence that Myc and G1 cyclin/CDKs regulate different aspects of E2F temporal dynamics, resulting in distinct phenotypic outputs. 01 September 2014 | doi: 10.1038/ncomms5750 Biological Sciences  Cell biology  Systems biology  Magnetic monopoles and unusual dynamics of magnetoelectrics D. I. Khomskii Magnetoelectrics are materials where intrinsic magnetism and ferroelectricity are coupled. Here, Khomskii argues that owing to this coupling, magnetoelectrics can have magnetic textures around electrical charges with properties analogue to magnetic monopoles. 01 September 2014 | doi: 10.1038/ncomms5793 Physical Sciences  Condensed matter  Materials science  A Cenozoic-style scenario for the end-Ordovician glaciation OPEN Jean-François Ghienne, André Desrochers, Thijs R.A. Vandenbroucke, Aicha Achab, Esther Asselin, Marie-Pierre Dabard, Claude Farley, Alfredo Loi, Florentin Paris, Steven Wickson and Jan Veizer Claims that the end-Ordovician Earth was characterized by giant ice sheets, yet paradoxically warm oceans and elevated CO2 levels are open to debate. Here, Ghienne et al. examine sedimentary records from low and high palaeolatitude settings and propose a revision of the mechanisms for end-Ordovician events. 01 September 2014 | doi: 10.1038/ncomms5485 Earth Sciences  Climate science  Geology and geophysics  Cultivation-based multiplex phenotyping of human gut microbiota allows targeted recovery of previously uncultured bacteria Elizabeth A. Rettedal, Heidi Gumpert and Morten O.A. Sommer Research on the roles played by gut microbes in human health is hampered by our inability to isolate and study them in pure cultures. Here, the authors describe an approach that allows targeted cultivation and rapid characterization of a significant proportion of human gut bacteria. 28 August 2014 | doi: 10.1038/ncomms5714 Biological Sciences  Microbiology  Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors Mario Sanches, Nicole M. Duffy, Manisha Talukdar, Nero Thevakumaran, David Chiovitti, Marella D. Canny, Kenneth Lee, Igor Kurinov, David Uehling, Rima Al-awar, Gennadiy Poda, Michael Prakesch, Brian Wilson, Victor Tam, Colleen Schweitzer, Andras Toro, Julie L. Lucas, Danka Vuga, Lynn Lehmann, Daniel Durocher et al. Modulation of the unfolded protein response by targeting IRE1 has several potential therapeutic applications. Here, the authors provide a first structural view of inhibitors engaging the RNase-active site of IRE1 that suggests avenues towards the generation of analogues with increased potency and selectivity. 28 August 2014 | doi: 10.1038/ncomms5202 Biological Sciences  Biochemistry  Chemical biology  Visualizing domain wall and reverse domain superconductivity M. Iavarone, S. A. Moore, J. Fedor, S. T. Ciocys, G. Karapetrov, J. Pearson, V. Novosad and S. D. Bader When superconductivity emerges in a thin superconductor grown on a ferromagnet, it does so in an array of interacting superconducting and normally conducting channels. Maria Iavarone and colleagues use scanning tunnelling microscopy to image how these channels form and interact. 28 August 2014 | doi: 10.1038/ncomms5766 Physical Sciences  Condensed matter  Energy landscape and dynamics of brain activity during human bistable perception OPEN Takamitsu Watanabe, Naoki Masuda, Fukuda Megumi, Ryota Kanai and Geraint Rees Bistable visual perception requires changes in brain activity between different cortical areas. Here, Watanabe et al. demonstrate dynamic patterns of brain activity during bistable visual perception, which link behavioural variability and anatomical individual differences in focal brain regions. 28 August 2014 | doi: 10.1038/ncomms5765 Biological Sciences  Neuroscience  Photovoltaic effect in few-layer black phosphorus PN junctions defined by local electrostatic gating Michele Buscema, Dirk J. Groenendijk, Gary A. Steele, Herre S.J. van der Zant and Andres Castellanos-Gomez Ambipolar transport, necessary to realise PN-junctions, is unfortunately missing from most two-dimensional semiconductors. Here, the authors fabricate few-layer black phosphorous field-effect transistors, define PN-junctions and demonstrate full electrostatic control of the device by means of local gating. 28 August 2014 | doi: 10.1038/ncomms5651 Physical Sciences  Materials science  Nanotechnology  Mycobacterium tuberculosis acquires iron by cell-surface sequestration and internalization of human holo-transferrin Vishant Mahendra Boradia, Himanshu Malhotra, Janak Shrikant Thakkar, Vikas Ajit Tillu, Bhavana Vuppala, Pravinkumar Patil, Navdeep Sheokand, Prerna Sharma, Anoop Singh Chauhan, Manoj Raje and Chaaya Iyengar Raje Mycobacterium tuberculosis acquires iron from its host by producing iron-binding siderophores and by recruiting host transferrin to the phagosome. Here, Boradia et al. show that the bacterial GAPDH protein binds transferrin and drives the uptake of this host protein into M. tuberculosis cells. 28 August 2014 | doi: 10.1038/ncomms5730 Biological Sciences  Cell biology  Microbiology  Crystal structure and its bearing towards an understanding of key biological functions of EpCAM Miha Pavšič, Gregor Gunčar, Kristina Djinović-Carugo and Brigita Lenarčič Epithelial cell adhesion protein (EpCAM) is a cell–cell adhesion molecule that is often used as a cancer cell marker. Here, Pavšič et al. solve the structure of a dimer of the extracellular domain of EpCAM, explain several aspects of its biology and comment on the antigenicity of its epitopes. 28 August 2014 | doi: 10.1038/ncomms5764 Biological Sciences  Biochemistry  Solution-state conformation and stoichiometry of yeast Sir3 heterochromatin fibres Sarah G. Swygert, Benjamin J. Manning, Subhadip Senapati, Parminder Kaur, Stuart Lindsay, Borries Demeler and Craig L. Peterson Heterochromatin is a ‘repressed’ chromatin state involved in the generation of centromeres, the protection of telomeres and the maintenance of genome integrity. Here Swygert et al. show that Sir3 - a key factor in the formation of heterochromatin - promotes a chromatin structure distinct from the canonical 30 nm fibre. 28 August 2014 | doi: 10.1038/ncomms5751 Biological Sciences  Molecular biology  Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages Jia Wang, Helen He Zhu, Mingliang Chu, Yunying Liu, Chenxi Zhang, Geng Liu, Xiaohang Yang, Ru Yang and Wei-Qiang Gao The role of cell division modes of basal and luminal epithelial cells in prostate development and tumorigenesis is unclear. Here, the authors show that while luminal cells contribute to development and tumorigenesis via symmetrical divisions, basal cells do so through asymmetric divisions. 28 August 2014 | doi: 10.1038/ncomms5758 Biological Sciences  Cancer  Cell biology  Multiple intrinsically identical single-photon emitters in the solid state OPEN L.J. Rogers, K.D. Jahnke, T. Teraji, L. Marseglia, C. Müller, B. Naydenov, H. Schauffert, C. Kranz, J. Isoya, L.P. McGuinness and F. Jelezko In quantum optical technologies, identical emitters of indistinguishable single photons are difficult to realize due to the inherent dissimilarity of each emitting device. Here, Rogers et al. demonstrate a solid-state uniform single-photon source, which does not require external tuning of optical properties. 27 August 2014 | doi: 10.1038/ncomms5739 Physical Sciences  Applied physics  Optical physics  UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation Cristina Militti, Sylvain Maenner, Peter B. Becker and Fátima Gebauer The process that balances expression of X-chromosomal genes between males and females is under tight regulatory control. Here, Militti et al. show that in Drosophila, the RNA-binding protein UNR functions during dosage compensation to promote the interaction between the RNA helicase MLE and the long non-coding RNA roX2. 27 August 2014 | doi: 10.1038/ncomms5762 Biological Sciences  Genetics  Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming OPEN Jason A. West, April Cook, Burak H. Alver, Matthias Stadtfeld, Aimee M. Deaton, Konrad Hochedlinger, Peter J. Park, Michael Y. Tolstorukov and Robert E. Kingston Changes in chromatin structure impact gene expression programs by modulating accessibility to the transcription machinery. Here, West et al. explore differences in nucleosome occupancy between mammalian pluripotent and somatic cells and uncover regulatory regions likely to play key roles in determining cell identity. 27 August 2014 | doi: 10.1038/ncomms5719 Biological Sciences  Genetics  Screening of DUB activity and specificity by MALDI-TOF mass spectrometry OPEN Maria Stella Ritorto, Richard Ewan, Ana B. Perez-Oliva, Axel Knebel, Sara J. Buhrlage, Melanie Wightman, Sharon M. Kelly, Nicola T. Wood, Satpal Virdee, Nathanael S. Gray, Nicholas A. Morrice, Dario R. Alessi and Matthias Trost Deubiquitylases (DUBs) remove ubiquitin chains from proteins. Here the authors develop a mass spectrometry-based DUB activity screen using unmodified diubiquitin isomers to characterize substrate specificity for 42 human DUBs, and assess the potency and selectivity of 11 DUB inhibitors. 27 August 2014 | doi: 10.1038/ncomms5763 Biological Sciences  Biochemistry  Bioinformatics  Recurrent CDC25C mutations drive malignant transformation in FPD/AML Akihide Yoshimi, Takashi Toya, Masahito Kawazu, Toshihide Ueno, Ayato Tsukamoto, Hiromitsu Iizuka, Masahiro Nakagawa, Yasuhito Nannya, Shunya Arai, Hironori Harada, Kensuke Usuki, Yasuhide Hayashi, Etsuro Ito, Keita Kirito, Hideaki Nakajima, Motoshi Ichikawa, Hiroyuki Mano and Mineo Kurokawa Familial platelet disorder with predisposition to acute myelogenous leukaemia (FPD/AML) is characterized by abnormal platelet function and a high risk of haematological malignancies. Here, the authors report frequent CDC25C mutations in FPD/AML patients and suggest that this gene may influence malignant transformation in FPD/AML. 27 August 2014 | doi: 10.1038/ncomms5770 Biological Sciences  Cancer  Genetics  Actin–microtubule coordination at growing microtubule ends OPEN Magdalena Preciado López, Florian Huber, Ilya Grigoriev, Michel O. Steinmetz, Anna Akhmanova, Gijsje H. Koenderink and Marileen Dogterom The structural cross-talk between components of the eukaryotic cytoskeleton remains poorly understood. Here the authors engineer an actin-binding microtubule tip-tracking protein that guides microtubule growth along actin bundles, and allows microtubule growing ends to pull and bundle actin filaments. 27 August 2014 | doi: 10.1038/ncomms5778 Biological Sciences  Cell biology  A genome-wide map of hyper-edited RNA reveals numerous new sites OPEN Hagit T. Porath, Shai Carmi and Erez Y. Levanon Common methods to detect adenosine-to-inosine RNA editing sites rely on mapping short RNA reads to the genome while allowing only a limited number of mismatches. Here, Porath et al. present a novel RNA-seq based approach to identify hyper-edited reads that significantly expands the RNA editome. 27 August 2014 | doi: 10.1038/ncomms5726 Biological Sciences  Bioinformatics  Molecular biology  The evolutionary origin of human hyper-cooperation J. M. Burkart, O. Allon, F. Amici, C. Fichtel, C. Finkenwirth, A. Heschl, J. Huber, K. Isler, Z. K. Kosonen, E. Martins, E.J. Meulman, R. Richiger, K. Rueth, B. Spillmann, S. Wiesendanger and C. P. van Schaik The evolutionary foundation of human prosociality remains poorly understood. Here, the authors show that extensive allomaternal care is the best predictor of prosocial behaviour among 15 primate species, including humans, which suggests that prosocial motivations arise along with cooperative breeding. 27 August 2014 | doi: 10.1038/ncomms5747 Biological Sciences  Evolution  Reproductive isolation related to mimetic divergence in the poison frog Ranitomeya imitator Evan Twomey, Jacob S. Vestergaard and Kyle Summers It is unclear how mimetic radiations, the evolution of a species to resemble different model species, contribute to speciation. Here, the authors show patterns of mating behaviour and genetic divergence, suggesting that mimetic divergence has promoted incipient speciation in a group of Peruvian poison frogs. 27 August 2014 | doi: 10.1038/ncomms5749 Biological Sciences  Evolution    Nature Communications JOBS of the week Bioinformatics Position (m / f) Fraunhofer Gesellschaft FhG, Institute for Molecular Biology and Applied Ecology (IME) Postdoctoral Position in Behavioral Neuroscience University of Gothenburg (GU) POSTDOC : Organic Memory Devices and their Implementation in Neuromorphic Circuits CEA French Atomic and Alternative Energies Commission Tenure Track Faculty Positions The Department of Genetics Washington University School of Medicine, St. Louis Graduate Research Position in Bacterial Genomics Clemson University PhD scholarship in Drug Delivery Technical University of Denmark (DTU) Senior Mass Spectrometrist / Head of Core Facility Proteomics University of Freiburg/ Centre for Systems Biology (ZBSA) Postdoctoral Researcher in Greenland Ice Sheet research (Two Posts) University of Bristol Editorial Team Leader Nucleus Global Research Associate University of Glasgow More Science jobs from Nature Communications EVENT The 6th Annual Personalized Medicine Conference 29.-30.10.14 San Francisco, US More science events from     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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