The EDGE

SPOTLIGHT ON EPIGENETICS IN HEMATOLOGIC MALIGNANCIES

The mechanistic role of DNA methylation in myeloid leukemogenesis

J Jasielec, V Saloura and L A Godley

Leukemia 2014 28: 1765-1773; advance online publication, May 20, 2014; 10.1038/leu.2014.163

Reviews

DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies

A P Im, A R Sehgal, M P Carroll, B D Smith, A Tefferi, D E Johnson and M Boyiadzis

Leukemia 2014 28: 1774-1783; advance online publication, April 4, 2014; 10.1038/leu.2014.124

The targeting of immunosuppressive mechanisms in hematological malignancies

M H Andersen

Leukemia 2014 28: 1784-1792; advance online publication, March 18, 2014; 10.1038/leu.2014.108

Concise Reviews

Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes—proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS

A Porwit, A A van de Loosdrecht, P Bettelheim, L Eidenschink Brodersen, K Burbury, E Cremers, M G Della Porta, R Ireland, U Johansson, S Matarraz, K Ogata, A Orfao, F Preijers, K Psarra, D Subirá, P Valent, V H J van der Velden, D Wells, T M Westers, W Kern and M C Béné on behalf of IMDSFlow

Leukemia 2014 28: 1793-1798; advance online publication, June 12, 2014; 10.1038/leu.2014.191

MYD88 and beyond: novel opportunities for diagnosis, prognosis and treatment in Waldenström’s Macroglobulinemia

O Landgren and N Tageja

Leukemia 2014 28: 1799-1803; advance online publication, February 27, 2014; 10.1038/leu.2014.88

Original Articles

CHRONIC MYELOPROLIFERATIVE NEOPLASIAS

The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: an international study of 797 patients

P Guglielmelli, T L Lasho, G Rotunno, J Score, C Mannarelli, A Pancrazzi, F Biamonte, A Pardanani, K Zoi, A Reiter, A Duncombe, T Fanelli, D Pietra, E Rumi, C Finke, N Gangat, R P Ketterling, R A Knudson, C A Hanson, A Bosi, A Pereira, R Manfredini, F Cervantes, G Barosi, M Cazzola, N C P Cross, A M Vannucchi and A Tefferi

Leukemia 2014 28: 1804-1810; advance online publication, February 19, 2014; 10.1038/leu.2014.76

Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value OPEN

A M Vannucchi, G Rotunno, N Bartalucci, G Raugei, V Carrai, M Balliu, C Mannarelli, A Pacilli, L Calabresi, R Fjerza, L Pieri, A Bosi, R Manfredini and P Guglielmelli on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators

Leukemia 2014 28: 1811-1818; advance online publication, March 12, 2014; 10.1038/leu.2014.100

ACUTE LEUKEMIAS

Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia

C Reynolds, J E Roderick, J L LaBelle, G Bird, R Mathieu, K Bodaar, D Colon, U Pyati, K E Stevenson, J Qi, M Harris, L B Silverman, S E Sallan, J E Bradner, D S Neuberg, A T Look, L D Walensky, M A Kelliher and A Gutierrez

Leukemia 2014 28: 1819-1827; advance online publication, February 20, 2014; 10.1038/leu.2014.78

SENSITIVITY AND RESISTANCE TO THERAPY

EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion

I M Ariës, I S Jerchel, R E S R van den Dungen, L C J van den Berk, J M Boer, M A Horstmann, G Escherich, R Pieters and M L den Boer

Leukemia 2014 28: 1828-1837; advance online publication, February 20, 2014; 10.1038/leu.2014.80

ONCOGENES, FUSION GENES AND TUMOR SUPPRESSOR GENES

The leukemogenicity of Hoxa9 depends on alternative splicing

C R Stadler, N Vegi, M A Mulaw, K E Edmaier, V P S Rawat, A Dolnik, L Bullinger, B Heilmeier, L Quintanilla-Fend, K Spiekermann, W Hiddemann, K Döhner, H Döhner, M Feuring-Buske and C Buske

Leukemia 2014 28: 1838-1843; advance online publication, February 18, 2014; 10.1038/leu.2014.74

STEM CELLS

Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia

M Matsunawa, R Yamamoto, M Sanada, A Sato-Otsubo, Y Shiozawa, K Yoshida, M Otsu, Y Shiraishi, S Miyano, K Isono, H Koseki, H Nakauchi and S Ogawa

Leukemia 2014 28: 1844-1850; advance online publication, February 18, 2014; 10.1038/leu.2014.73

G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling

L G Schuettpelz, J N Borgerding, M J Christopher, P K Gopalan, M P Romine, A C Herman, J R Woloszynek, A M Greenbaum and D C Link

Leukemia 2014 28: 1851-1860; advance online publication, February 12, 2014; 10.1038/leu.2014.68

LYMPHOMA

BIM upregulation and ROS-dependent necroptosis mediate the antitumor effects of the HDACi Givinostat and Sorafenib in Hodgkin lymphoma cell line xenografts

S L Locatelli, L Cleris, G G Stirparo, S Tartari, E Saba, M Pierdominici, W Malorni, A Carbone, A Anichini and C Carlo-Stella

Leukemia 2014 28: 1861-1871; advance online publication, February 24, 2014; 10.1038/leu.2014.81

TGF-β upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell non-Hodgkin’s lymphoma

Z-Z Yang, D M Grote, B Xiu, S C Ziesmer, T L Price-Troska, L S Hodge, D M Yates, A J Novak and S M Ansell

Leukemia 2014 28: 1872-1884; advance online publication, February 26, 2014; 10.1038/leu.2014.84

Intensified chemo-immunotherapy with or without stem cell transplantation in newly diagnosed patients with peripheral T-cell lymphoma

P Corradini, U Vitolo, A Rambaldi, R Miceli, F Patriarca, A Gallamini, A Olivieri, F Benedetti, G Todeschini, G Rossi, F Salvi, B Bruno, L Baldini, A Ferreri, C Patti, C Tarella, S Pileri and A Dodero on behalf of Fondazione Italiana Linfomi

Leukemia 2014 28: 1885-1891; advance online publication, February 20, 2014; 10.1038/leu.2014.79

MYELOMA

A novel Bruton’s tyrosine kinase inhibitor CC-292 in combination with the proteasome inhibitor carfilzomib impacts the bone microenvironment in a multiple myeloma model with resultant antimyeloma activity

H Eda, L Santo, D D Cirstea, A J Yee, T A Scullen, N Nemani, Y Mishima, P R Waterman, S Arastu-Kapur, E Evans, J Singh, C J Kirk, W F Westlin and N S Raje

Leukemia 2014 28: 1892-1901; advance online publication, February 12, 2014; 10.1038/leu.2014.69

Predictive value of longitudinal whole-body magnetic resonance imaging in patients with smoldering multiple myeloma

M Merz, T Hielscher, B Wagner, S Sauer, S Shah, M S Raab, A Jauch, K Neben, D Hose, G Egerer, M-A Weber, S Delorme, H Goldschmidt and J Hillengass

Leukemia 2014 28: 1902-1908; advance online publication, February 18, 2014; 10.1038/leu.2014.75

Letters to the Editor

An aberrant microRNA signature in childhood T-cell lymphoblastic lymphoma affecting CDKN1B expression, NOTCH1 and growth factor signaling pathways

L Mussolin, A B Holmes, C Romualdi, G Sales, E S G D'Amore, M Ghisi, M Pillon, A Rosolen and K Basso

Leukemia 2014 28: 1909-1912; advance online publication, April 14, 2014; 10.1038/leu.2014.134

Analysis of calreticulin mutations in Chinese patients with essential thrombocythemia: clinical implications in diagnosis, prognosis and treatment

R Fu, M Xuan, Y Zhou, T Sun, J Bai, Z Cao, L Zhang, H Li, D Zhang, X Zhang, C Lv, F Xue, X Liu, R Yang and L Zhang

Leukemia 2014 28: 1912-1914; advance online publication, April 15, 2014; 10.1038/leu.2014.138

Effect of FTY720 on the SET–PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity

R Pippa, A Dominguez, D J Christensen, I Moreno-Miralles, M J Blanco-Prieto, M P Vitek and M D Odero

Leukemia 2014 28: 1915-1918; advance online publication, April 30, 2014; 10.1038/leu.2014.141

Acceleration of Bcr-Abl⁺ leukemia induced by deletion of JAK2 OPEN

E Grundschober, A Hoelbl-Kovacic, N Bhagwat, B Kovacic, R Scheicher, E Eckelhart, K Kollmann, M Keller, F Grebien, K-U Wagner, R L Levine and V Sexl

Leukemia 2014 28: 1918-1922; advance online publication, May 5, 2014; 10.1038/leu.2014.152

Circulating miRNA markers show promise as new prognosticators for multiple myeloma

A Rocci, C C Hofmeister, S Geyer, A Stiff, M Gambella, L Cascione, J Guan, D M Benson, Y A Efebera, T Talabere, V Dirisala, E M Smith, P Omedè, G Isaia, L De Luca, D Rossi, S Gentili, G Uccello, J Consiglio, R Ria, G Benevolo, S Bringhen, V Callea, B Weiss, A Ferro, V Magarotto, H Alder, J C Byrd, M Boccadoro, G Marcucci, A Palumbo and F Pichiorri

Leukemia 2014 28: 1922-1926; advance online publication, May 12, 2014; 10.1038/leu.2014.155

Impact of chemotherapy delay on short- and long-term survival in younger and older AML patients: a Danish population-based cohort study

L S G Østgard, J M Nørgaard, H Sengeløv, M S Holm, M K Jensen, M Kallenbach, C W Marcher, O J Nielsen and M Nørgaard

Leukemia 2014 28: 1926-1929; advance online publication, May 12, 2014; 10.1038/leu.2014.157

APOBEC3 signature mutations in chronic lymphocytic leukemia OPEN

S Rebhandl, M Huemer, F J Gassner, N Zaborsky, D Hebenstreit, K Catakovic, E M Grössinger, R Greil and R Geisberger

Leukemia 2014 28: 1929-1932; advance online publication, May 20, 2014; 10.1038/leu.2014.160

Low frequency of calreticulin mutations in MDS patients

M Heuser, V Panagiota, C Koenecke, B Fehse, H Alchalby, A Badbaran, R Shahswar, M Stadler, M Eder, G Göhring, A Trummer, T Schroeder, G Kobbe, C Thiede, U Platzbecker, B Schlegelberger, N Kroeger, A Ganser and F Thol

Leukemia 2014 28: 1933-1934; advance online publication, May 21, 2014; 10.1038/leu.2014.165

Reduction of leukemia cell burden and restoration of normal hematopoiesis at 3 months of crizotinib treatment in RAN-binding protein 2 (RANBP2)–anaplastic lymphoma kinase (ALK) acute myeloid leukemia

Y Maesako, A Okumura, K Takeoka, C Kishimori, K Izumi, Y Kamoda, F Iioka, T Akasaka and H Ohno

Leukemia 2014 28: 1935-1937; advance online publication, May 21, 2014; 10.1038/leu.2014.166

Follicular lymphoma transformation into histiocytic sarcoma: indications for a common neoplastic progenitor

P Brunner, A Rufle, S Dirnhofer, A Lohri, N Willi, G Cathomas, A Tzankov and D Juskevicius

Leukemia 2014 28: 1937-1940; advance online publication, May 21, 2014; 10.1038/leu.2014.167