The EMBO Journal Table of Contents for 16 April 2014; Vol. 33, No. 8

16 April 2014 | Volume 33, Number 8 Submit Table of Contents Have you seen? Reviews Articles Volume 33, Number 8 Have you seen? LTP: GluN2B on the go Lateral diffusion of neuronal NMDA receptors is important for synaptic long‐term potentiation and may be affected in autoimmune disorders. Lucas Matt and Johannes W Hell Published online 05.03.2014 Rad17, the clamp loader that loads more than clamps Best known for its upstream role in ATR kinase signaling, Rad17 gains unexpected new roles in promoting early ATM checkpoint responses to DNA double‐strand breaks. Tanya T Paull and Ji‐Hoon Lee Published online 11.03.2014 SERPINs shelter the endowed migrants in a hostile land Metastatic cells have to deploy mechanisms that warrant their survival and growth in target organs. A recent study in Cell unravels serpin's functions that enable cancer cells to initiate brain metastases. Weilan Ye Published online 11.03.2014 Reviews Synaptic vesicle recycling: steps and principles Silvio Rizzoli reviews the different steps and mechanisms involved in synaptic vesicle biogenesis and recycling. Silvio O Rizzoli Published online 03.03.2014 Role of receptor binding specificity in influenza A virus transmission and pathogenesis Recent cases of humans carrying avian Influenza strains highlight the importance of unraveling the role of virus‐receptor interactions in cross‐species adaptation. de Graaf and Fouchier review how virus hemagglutinin binding to host receptors governs virus pathogenesis, transmission and host spectrum. Miranda de Graaf and Ron A M Fouchier Published online 25.03.2014 Articles Surface dynamics of GluN2B‐NMDA receptors controls plasticity of maturing glutamate synapses Long‐term potentiation in immature hippocampal neurons requires glutamate receptor lateral diffusion and CaMKII recruitment, a process that can be blocked by autoimmune anti‐NMDAR antibodies from patients with neuropsychiatric symptoms. Julien P Dupuis, Laurent Ladépêche, Henrik Seth, Lucie Bard, Juan Varela, Lenka Mikasova, Delphine Bouchet, Véronique Rogemond, Jérôme Honnorat, Eric Hanse, and Laurent Groc Published online 03.03.2014 Rad17 recruits the MRE11‐RAD50‐NBS1 complex to regulate the cellular response to DNA double‐strand breaks The DNA damage sensor protein RAD17 constitutes an unexpected MDC1‐independent mechanism for early recruitment of ATM‐activating MRN complexes to DNA double‐strand breaks. Qinhong Wang, Michael Goldstein, Peter Alexander, Timothy P Wakeman, Tao Sun, Junjie Feng, Zhenkun Lou, Michael B Kastan, and Xiao‐Fan Wang Published online 16.02.2014 Fip1 regulates mRNA alternative polyadenylation to promote stem cell self‐renewal Alternative polyadenylation is an emerging key post‐transcriptional regulatory mechanism. The essential role for mRNA 3′ end processing factor Fip1 in stem cell self‐renewal and pluripotency reveals the importance of poly(A) site choice. Brad Lackford, Chengguo Yao, Georgette M Charles, Lingjie Weng, Xiaofeng Zheng, Eun‐A Choi, Xiaohui Xie, Ji Wan, Yi Xing, Johannes M Freudenberg, Pengyi Yang, Raja Jothi, Guang Hu, and Yongsheng Shi Published online 04.03.2014 Genome‐wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co‐activation Two major tumor suppressors bind to and co‐regulate highly transcribed genes in breast epithelial cells, including NF‐κB targets and retinoic acid‐responsive genes. Alessandro Gardini, David Baillat, Matteo Cesaroni, and Ramin Shiekhattar Published online 03.03.2014 miR379–410 cluster miRNAs regulate neurogenesis and neuronal migration by fine‐tuning N‐cadherin Members of the miR379–410 miRNA cluster control the proliferation and differentiation of radial glial cells (RGCs) and the migration of cortical neurons by reducing N‐cadherin levels in the developing neocortex. Luciano Rago, Robert Beattie, Verdon Taylor, and Jennifer Winter Published online 10.03.2014 Human telomerase specialization for repeat synthesis by unique handling of primer‐template duplex The telomerase‐specific TEN domain emerges as the key for adapting general reverse transcriptase function to multiple telomeric repeat synthesis from short primer‐template hybrids. Robert Alexander Wu and Kathleen Collins Published online 11.03.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.