Nature Reviews Neuroscience contents May 2014 Volume 15 Number 5 pp 279-345

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TABLE OF CONTENTS
May 2014 Volume 15 Number 5
Impact Factor 31.673 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease Marco Prinz & Josef Priller
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RESEARCH HIGHLIGHTS Top Neurodegeneration: Ageing neurons need REST p279 | doi:10.1038/nrn3728 The transcription factor REST has a neuroprotective role in the healthy ageing brain that is disrupted in Alzheimer's disease. PDF IN THE NEWS A blood test for Alzheimer's disease? p280 | doi:10.1038/nrn3726 A recent study has identified a potential blood-based biomarker for Alzheimer's disease. PDF Neurodevelopment: Pruning: a class I act p280 | doi:10.1038/nrn3732 Neuronally expressed major histocompatibility complex class I molecule H2-Db regulates structural and functional plasticity at retinogeniculate synapses. PDF Synaptic plasticity: Microglial cell-mediated depression p280 | doi:10.1038/nrn3733 Activation of microglial complement receptor 3 by an inflammatory stimulus in the presence of hypoxia induces long-term depression of synaptic transmission in the hippocampus. PDF Learning and memory: Out of body, out of mind p282 | doi:10.1038/nrn3727 An event that is experienced from an 'out-of-body' perspective is remembered less well and its recall does not induce the usual pattern of hippocampal activation. PDF Gap junctions: Inputs alter coupling strength p282 | doi:10.1038/nrn3741 Both GABAergic and glutamatergic projections can modulate the strength of electrical coupling between inferior olive neurons and alter neuron synchronization in the cerebellar inferior olive. PDF IN BRIEF Sensory processing: 'Seeing' bodies via sounds | Learning and memory: The hippocampus encodes objects in time | Olfaction: The nose knows one trillion smells | Neurophysiology: Pericytes set the tone | Neuroimaging: Functional networks are short-lived | Transporters: Channelling seizure susceptibility | Sensory processing: Shifting states PDF Neuroscience JOBS of the week Postdoctoral Research Fellow, Molecular Neuroscience / Computational Neuroscience George Mason University Assistant / Associate Professor Faculty Position in Neuroscience University of North Dakota, School of Medicine Health Sciences Associate Researcher Icahn School of Medicine at Mount Sinai Canada Research Chair Tier II in Magnetic Resonance Spectroscopy and Brain Injury University of Calgary & Alberta Children's Research Institute More Science jobs from Neuroscience EVENT Computational Neuroscience: Vision 11.07.14 Cold Spring Harbor, USA More science events from
REVIEWS		Top
Nuclear and cytosolic JNK signalling in neurons Eleanor T. Coffey p285 | doi:10.1038/nrn3729 JUN amino-terminal kinases (JNKs) regulate various processes in neurodevelopment and the adult brain. In this Review, Coffey examines the neuronal functions of JNKs and the therapeutic potential of targeting these kinases in various diseases of the nervous system. Abstract | Full Text | PDF | Supplementary information
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease Marco Prinz & Josef Priller p300 | doi:10.1038/nrn3722 Microglia and macrophages have crucial roles in nervous system development, maintenance and disease. In this Review, Prinz and Priller describe recently discovered details of the embryonic origins and functions of microglia that distinguish them from the other macrophage populations that reside in the brain. Abstract | Full Text | PDF
Restoring sensorimotor function through intracortical interfaces: progress and looming challenges Sliman J. Bensmaia & Lee E. Miller p313 | doi:10.1038/nrn3724 Intracortical brain–machine interfaces with sensorimotor cortices are one approach by which a person can exert voluntary control over a prosthetic limb or paralysed muscles. In this Review, Bensmaia and Miller review recent achievements and remaining challenges in the development of intracortical brain–machine interfaces. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Astrocyte Ca2+ signalling: an unexpected complexity Andrea Volterra, Nicolas Liaudet & Iaroslav Savtchouk p327 | doi:10.1038/nrn3725 The role of astrocytic Ca2+ signalling in synaptic function remains elusive. In this Opinion article, Volterra and colleagues discuss how recent data reveal an unexpected complexity of Ca2+ dynamics in astrocytes, which both challenges current thinking and suggests a new conceptual and experimental framework to address astrocyte function. Abstract | Full Text | PDF
OPINION How does the bilingual experience sculpt the brain? Albert Costa & Núria Sebástian-Gallés p336 | doi:10.1038/nrn3709 Bilingualism has attracted attention for its reported effects on linguistic and cognitive abilities. In this Opinion article, Costa and Sebástian-Gallés provide their view on how learning and speaking two languages affects language acquisition and processing as well as executive control processes. Abstract | Full Text | PDF
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