Nature Reviews Genetics Contents May 2014 Volume 15 Number 5 pp 287-359

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TABLE OF CONTENTS
May 2014 Volume 15 Number 5
Impact Factor 41.063 *	In this issue Research Highlights Reviews Also this month Article series: Disease mechanisms Applications of next-generation sequencing Study designs  Featured article: Gene expression regulation mediated through reversible m6A RNA methylation Ye Fu, Dan Dominissini, Gideon Rechavi & Chuan He
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RESEARCH HIGHLIGHTS Top Human genetics: Autism — clues from brains and protein domains p287 | doi:10.1038/nrg3715 PDF Clinical genetics: DNA sequencing trumps standard screening tools p288 | doi:10.1038/nrg3716 PDF Plant genetics: Plastid genomes — lost in translation? p288 | doi:10.1038/nrg3717 PDF Evolution: Cancer drivers everywhere? p289 | doi:10.1038/nrg3718 PDF IN THE NEWS Rett syndrome scientist honoured p290 | doi:10.1038/nrg3719 PDF Genomics: A catalogue of human gene activity p290 | doi:10.1038/nrg3720 PDF Microbial genetics: Bacterial sensors report on the gut p290 | doi:10.1038/nrg3721 PDF IN BRIEF Evolutionary genetics: Selective inheritance of mitochondrial DNA | RNA: easiRNAs — guardians of the plant genome | Human genetics: In your face — predicting facial features from DNA | DNA Elements: Determinants of site-specific hypermutation | Technology: In vivo correction of genetic disease in adult mice | Disease genetics: Non-invasive monitoring of resistance mutations | Transposable elements: A pluripotency role for a retroviral element PDF Genetics JOBS of the week Postdoctoral Fellow Position in Small RNAs and Gene Regulation University of California - Riverside Faculty University of Texas Medical School- Houston Postdoctoral Position in Hypoxia Signaling in Cancer ETH Zurich Postdoctoral fellow University of Southern California Postdoctoral Fellow University of Virginia More Science jobs from Genetics EVENT Genetic Approaches to Study the Neurobiology of Learning and Memory 27.11.14 London, UK More science events from
REVIEWS		Top
Gene expression regulation mediated through reversible m6A RNA methylation Ye Fu, Dan Dominissini, Gideon Rechavi & Chuan He p293 | doi:10.1038/nrg3724 Diverse types of RNA in various species are modified by methylation to form N6-methyladenosine (m6A). This Review describes how progress in the characterization of m6A distributions and of proteins that 'write', 'erase' and 'read' this mark is revealing roles for reversible m6A methylation in dynamic gene expression control. Abstract | Full Text | PDF
Article series: Disease mechanisms Genomic insights into tuberculosis James E. Galagan p307 | doi:10.1038/nrg3664 This Review describes how genomic technologies are providing novel insights into Mycobacterium tuberculosis, which is the causative agent of human tuberculosis. There has been progress in understanding the ancient evolutionary history of human-adapted M. tuberculosis, mutations underlying strain diversity and drug resistance, and the host–pathogen molecular interactions. Abstract | Full Text | PDF | Supplementary information
A guide to genome engineering with programmable nucleases Hyongbum Kim & Jin-Soo Kim p321 | doi:10.1038/nrg3686 Programmable nucleases — including ZFNs, TALENs and RGENs derived from the prokaryotic CRISPR–Cas system — enable targeted high-precision genome engineering. This Review summarizes current knowledge of nuclease-specific features, individual pros and cons, and approaches to improve the efficiency of these enzymes to help researchers to choose the most appropriate tool for various genome editing experiments and applications. Abstract | Full Text | PDF
Article series: Study designs Statistical power and significance testing in large-scale genetic studies Pak C. Sham & Shaun M. Purcell p335 | doi:10.1038/nrg3706 This Review discusses the principles and applications of significance testing and power calculation, including recently proposed gene-based tests for rare variants. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing Comparative primate genomics: emerging patterns of genome content and dynamics Jeffrey Rogers & Richard A. Gibbs p347 | doi:10.1038/nrg3707 Whole-genome assemblies of humans and non-human primates are yielding data on the evolutionary origins of the human genome, as well as insights into genetic similarities and differences between species used as models for disease-related research. This Review discusses current knowledge and opportunities for comparative primate genomics created by recent advances in genome sequencing technologies. Abstract | Full Text | PDF | Supplementary information
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