Nature Reviews Molecular Cell Biology contents May 2014 Volume 15 Number 5 pp 295-362

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TABLE OF CONTENTS
May 2014 Volume 15 Number 5		Advertisement
Impact Factor 37.162 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Technologies and techniques  Featured article: The dynamic epitranscriptome: N6-methyladenosine and gene expression control Kate D. Meyer and Samie R. Jaffrey	Live cell RNA Detection made possible by SmartFlare™ technology. SmartFlare™ probes enable detection of RNA in live cells, connecting gene expression to specific phenotypes. The probes enter cells with no toxicity and leave after detection, allowing the same cells to be used for downstream assays.
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RESEARCH HIGHLIGHTS Top Post-translational modification: Sweetening protein quality control p295 | doi:10.1038/nrm3787 The activation of the hexosamine biosynthetic pathway following endoplasmic reticulum stress promotes cell protection and longevity. PDF Development: Keeping your cell identity p296 | doi:10.1038/nrm3794 The Polycomb protein Enhancer of zeste (E(z)) functions non-cell autonomously to maintain germ cell identity in Drosophila melanogaster. PDF Metabolism: YAP and TAZ under metabolic control p296 | doi:10.1038/nrm3796 The SREBP-mevalonate pathway promotes the activity of YAP and TAZ. PDF Molecular motors: Hook-ing up early endosomes p297 | doi:10.1038/nrm3795 Two fungal Hook proteins are identified as recruiting motor proteins to early endosomes for microtubule-based transport. PDF RNA interference: microRNAs suppress transposons p298 | doi:10.1038/nrm3788 The biogenesis of epigenetically activated siRNAs (easiRNAs) is triggered in plants by microRNAs to silence transposons. PDF In the news p298 | doi:10.1038/nrm3793 A recent report in Science describes the design and construction of an entire, engineered eukaryotic chromosome in yeast. PDF Gene expression: RNAi as a global transcriptional activator p298 | doi:10.1038/nrm3797 The CSR-1 RNAi pathway activates transcription at a genome-wide level by controlling RNA polymerase II directionality. PDF JOURNAL CLUB Conservative DNA Replication p300 | doi:10.1038/nrm3784 Thanos D. Halazonetis describes the discovery that break-induced replication is conservative in budding yeast. PDF DNA damage response: Mitosis: don't 'repair' the telomere! p300 | doi:10.1038/nrm3792 DNA double-strand breaks are not repaired during mitosis. Orthwein et al. now show that this is to prevent uncapped telomeres from fusing and causing aneuploidy. PDF IN BRIEF Post-translational modification: A new histone mark | Protein folding: Protein aggregation inhibits endocytosis | Cell cycle: Cnn as a scaffold for centrosome maturation PDF Nature Reviews Molecular Cell Biology JOBS of the week PhD student German Cancer Research Center (DKFZ) Postdoctor fellowship University of Sao Paulo - USP Postdoctoral Associate University of Texas MD Anderson Cancer Center PhD position Jules Bordet Institute More Science jobs from Nature Reviews Molecular Cell Biology EVENT More science events from
REVIEWS		Top
Plant and animal stem cells: similar yet different Renze Heidstra & Sabrina Sabatini p301 | doi:10.1038/nrm3790 As in animals, plant stem cells reside in stem cell niches, which produce signals that regulate the balance between self-renewal and differentiation into new tissues. Continuous organ production that is characteristic of plant growth requires a robust regulatory network to maintain this balance. Elucidating this network provides an opportunity to compare plant and animal stem cell strategies. Abstract | Full Text | PDF
The dynamic epitranscriptome: N6-methyladenosine and gene expression control Kate D. Meyer & Samie R. Jaffrey p313 | doi:10.1038/nrm3785 The results of transcriptome-wide N6-methyladenosine (m6A) mapping techniques have resolved many of the long-standing concerns regarding the physiological relevance of m6A, which suggests that this modification regulates mRNA fate and function. The identification of adenosine methylases and demethylases provides insights into the cellular pathways that involve m6A and indicates a role of m6A in physiological processes. Abstract | Full Text | PDF | Supplementary information
Article series: Technologies and techniques Advances in whole-embryo imaging: a quantitative transition is underway Periklis Pantazis & Willy Supatto p327 | doi:10.1038/nrm3786 Advances over the past decade in the development of imaging probes, microscopy techniques and image analysis have enabled researchers to gain a deeper knowledge and understanding of the dynamic processes of embryonic differentiation, patterning and morphogenesis through quantitative whole-animal imaging studies with high spatiotemporal resolution. Abstract | Full Text | PDF
What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory Philipp A. Steffen & Leonie Ringrose p340 | doi:10.1038/nrm3789 Epigenetic memory maintains gene expression states through cell generations, in the absence of the initiating signals or changes in DNA sequence. Our understanding of how the Polycomb (PcG) and Trithorax (TrxG) group proteins confer long-term, mitotically heritable memory by sustaining silent and active gene expression states, respectively, during DNA replication and mitosis, is increasing. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION DEP domains: structurally similar but functionally different Sarah V. Consonni, Madelon M. Maurice & Johannes L. Bos p357 | doi:10.1038/nrm3791 Dishevelled, EGL-10 and pleckstrin (DEP) domains carry out diverse functions by using different binding interfaces with well-defined structural features. It is becoming apparent that DEP domains mainly function in the spatial and temporal control of diverse signal transduction events by interacting with various partners at the plasma membrane. Abstract | Full Text | PDF
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