Nature Reviews Immunology Contents May 2014 Volume 14 Number 5 pp 281-349

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Self-antigen presentation by dendritic cells in autoimmunity (open access) In this review, Veronika Lukacs-Kornek and colleagues discuss the role of DCs in autoimmune diseases, the various factors involved in the induction and maintenance of tolerogenic DC phenotype, and pinpoints their therapeutic capacity as well as potential novel targets for future clinical studies. Read more high quality articles from Frontiers in Immunology
TABLE OF CONTENTS
May 2014 Volume 14 Number 5
Impact Factor 33.129 *	In this issue Research Highlights Reviews Perspectives Correspondence Also this month  Featured article: Emergency granulopoiesis Markus G. Manz & Steffen Boettcher
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Nature Reviews Immunology  Focus on Homeostatic immune responses  Homeostasis - literally 'standing still' - describes the mechanisms by which biological systems maintain stability. In this context, it is important to understand how immune pathways operate in steady-state conditions and the consequences of their dysfunction. The Review articles in this Focus tackle these issues as exemplified by host-commensal relationships in the gut, fibrosis during wound healing in the liver, the clearance of apoptotic cells from tissues and the context-specific functions of regulatory T cells.
RESEARCH HIGHLIGHTS Top Innate lymphoid cells: Breathing into allergic inflammation p281 | doi:10.1038/nri3668 Group 2 innate lymphoid cells are required to mount an effective type 2 immune response after the inhalation of allergens. PDF Immunometabolism: IL-6, the resistance fighter p282 | doi:10.1038/nri3670 IL-6 signalling in macrophages limits obesity-associated inflammation and the development of insulin resistance. PDF Parasite immunity: Protective teamwork p282 | doi:10.1038/nri3673 In response to parasite infection, nitric oxide is produced not only by infected cells but also by recruited phagocytes. PDF Regulatory T cells: Promoting B cell responses to influenza virus p283 | doi:10.1038/nri3662 Regulatory T cells promote the differentiation of T follicular helper cells. PDF Lymphoid tissues: Tertiary education p284 | doi:10.1038/nri3663 Differential chemokine induction by pathogens leads to the development of distinct tertiary lymphoid tissues. PDF Development: We are what mum eats! p284 | doi:10.1038/nri3672 Retinoic acid promotes secondary lymphoid organ formation during embryogenesis to establish adult immunity. PDF Natural killer cells: A TACTILE restraint p285 | doi:10.1038/nri3664 The immunoglobulin superfamily member CD96 binds CD155 to negatively control cytokine production by natural killer cells. PDF Innate immunity: Skin fibroblasts shield mast cells p286 | doi:10.1038/nri3680 Local fibroblasts prevent mast cell activation in the skin by degrading retinoic acid. PDF Inflammasomes: Polymeric assembly p287 | doi:10.1038/nri3669 Inflammasome assembly involves prion-like polymerization of the pyrin domain of the adaptor ASC. PDF IN BRIEF MHC molecules: Tweaking developing synapses | Asthma and allergy: Diagnostic methods are moving on... | B cells: Signal strengths BOB up and down | Parasite immunity: Innate immune response to the liver stage of malaria | Neutrophils: Sensing calcium to kill | Neutrophils: Disrupting the 'neutrostat' in LAD-I PDF Immunology JOBS of the week Post-doctoral position in T-cell Immunology University of Houston, Dept. of Chemical & Biomol Engg Postdoctoral Associate in Immunology Virginia Tech Faculty in Immunology and Rheumatology Shanghai Institute of Rheumatology, Jiaotong University PhD Studentship in Calcium and Redox Signalling in Immune and Skin Cells School of Medicine, University of Saarland Tenure-Track Assistant Professor Towards Associate Professor in Immune Engineering University of Lausanne (UNIL) More Science jobs from Immunology EVENT Tumor Immunology 01.12.14 Orlando, USA More science events from
REVIEWS		Top
Mechanisms regulating skin immunity and inflammation Manolis Pasparakis, Ingo Haase & Frank O. Nestle p289 | doi:10.1038/nri3646 Immune homeostasis in the skin requires dynamic crosstalk between epithelial, stromal and immune cells, which is influenced by environmental insults and commensal microorganisms. Here, the authors highlight recent studies that provide an insight into the immunoregulatory mechanisms that mediate host defence and prevent chronic inflammation in the skin. Abstract | Full Text | PDF
Emergency granulopoiesis Markus G. Manz & Steffen Boettcher p302 | doi:10.1038/nri3660 A summary of the molecular and cellular events that coordinate the markedly increased de novo production of neutrophils in response to systemic microbial infection. Abstract | Full Text | PDF
Innate immunity to influenza virus infection Akiko Iwasaki & Padmini S. Pillai p315 | doi:10.1038/nri3665 The recognition of influenza virus by multiple pattern recognition receptors initiates numerous defence mechanisms to control disease through their effects on antiviral resistance and disease tolerance. Here, the authors review these mechanisms and discuss how the treatment of influenza virus-initiated diseases should promote both of these protective strategies to improve host fitness. Abstract | Full Text | PDF
Cytokines in inflammatory bowel disease Markus F. Neurath p329 | doi:10.1038/nri3661 This Review covers the cellular sources and immune functions of the various cytokines that have been associated with inflammatory bowel disease (IBD). The author details how the dysregulated production of pro-inflammatory and anti-inflammatory cytokines can drive IBD pathology, and discusses the feasibility of targeting different cytokines for the future therapy of IBD. Abstract | Full Text | PDF
PERSPECTIVES		Top
TIMELINE FOXP3 and scurfy: how it all began Fred Ramsdell & Steven F. Ziegler p343 | doi:10.1038/nri3650 The molecular cloning of the forkhead box P3 (FOXP3) gene led to a renaissance in the field of suppressor T cells (now known as regulatory T cells). In this Timeline article, the authors describe the key events that demonstrated the importance of FOXP3 in immune regulation, starting with the discovery of the scurfy mouse some 65 years ago. Abstract | Full Text | PDF
CORRESPONDENCE		Top
IVIG pluripotency and the concept of Fc-sialylation: challenges to the scientist Stephan von Gunten, Yehuda Shoenfeld, Miri Blank, Donald R. Branch, Tchavdar Vassilev, Fabian Käsermann, Jagadeesh Bayry, Srini Kaveri & Hans-Uwe Simon p349 | doi:10.1038/nri3401-c1 Full Text | PDF
Reply to — IVIG pluripotency and the concept of Fc-sialylation: challenges to the scientist Inessa Schwab, Anja Lux & Falk Nimmerjahn p349 | doi:10.1038/nri3401-c2 Full Text | PDF
Erratum: The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams, Pierre Bruhns, Yvan Saeys, Hamida Hammad & Bart N. Lambrecht p349 | doi:10.1038/nri3666 Full Text | PDF
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