Nature Cell Biology contents: April 2014 Volume 16 Number 4, pp 293 - 383

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Advertisement BD Horizon Brilliant™ Ultraviolet Expand your research capabilities by adding ultraviolet excitable dyes to your multicolor panel design. Special offers available for a whole new spectrum of choice and productivity, along with tools and information to help you get the most from your studies. bdbiosciences.com/go/ultra TABLE OF CONTENTS April 2014 Volume 16, Issue 4 Review News and Views Research Highlights Articles Letters Errata Corrigenda Subscribe   Facebook   RSS   Recommend to library   Twitter   Review Top The biogenesis of chromosome translocations   pp293 - 300 Vassilis Roukos and Tom Misteli doi:10.1038/ncb2941 Repair of a chromosome break can result in part of a chromosome attaching to a different chromosome, causing gene deregulation and disease. Roukos and Misteli discuss the spatial aspect of chromosome translocation and the role of DNA repair pathways in this process. News and Views Top Understanding tissue context influences on intratumour heterogeneity   pp301 - 302 Franziska Michor and Valerie M. Weaver doi:10.1038/ncb2942 Although human cancers exhibit intratumour heterogeneity, the influence of the tumour environment on this property is unclear. Single basal-like mammary epithelial cells are now shown to engage a dynamic TGFBR3-JUND signalling circuit in an extracellular-matrix-dependent manner. Cell transition between the distinct gene expression states underlying this circuit alters their properties and may modulate their propensity to malignancy. See also: Article by Wang et al. Towards elucidating the tubulin code   pp303 - 305 Annemarie Wehenkel and Carsten Janke doi:10.1038/ncb2938 Genetically encoded and post-translationally generated variations of tubulin C-terminal tails give rise to extensive heterogeneity of the microtubule cytoskeleton. The generation of different tubulin variants in yeast now demonstrates how single amino-acid differences or post-translational modifications can modulate the behaviour of selected molecular motors. See also: Article by Sirajuddin et al. Differential adhesion drives angiogenesis   pp305 - 306 E. Dejana and M. G. Lampugnani doi:10.1038/ncb2943 New blood vessels sprout from existing vasculature to ensure vascularization of developing organs and tissues. A combination of computational modelling and experimental analysis shows that sprout elongation is mediated by differential adhesion dynamics among endothelial cells. The adhesiveness of an individual endothelial cell is governed by VEGF and Notch signalling. See also: Article by Bentley et al. Cell Biology JOBS of the week Postdoctoral Positions in Stem Cell Biology State University of New York Postdoctoral Position in Chromosome Dynamics and Recombination Institut Curie Research Center Postdoctoral Research Associate University of North Carolina at Chapel Hill Postdoctoral Mount Sinai Medical Center/Icahn School of Medicine at Mount Sinai Postdoctoral Position in Hypoxia Signaling in Cancer ETH Zurich More Science jobs from Cell Biology EVENT 2nd Advances in Stem Cell Biology Course 30th June – 12th July 2014 Paris, France More science events from Research Highlights Top RIPK3 kinase activity determines death pathway | Evading the defence against brain metastasis | Tight control of HSC protein synthesis | Generating energy with mitochondrial fission Advertisement Introducing the S3(TM) Cell Sorter from Bio-Rad. This state-of-the-art benchtop solution features automated setup and costs up to 50% less than traditional systems. Watch the Video    Articles Top The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis   pp309 - 321 Katie Bentley, Claudio Areias Franco, Andrew Philippides, Raquel Blanco, Martina Dierkes et al. doi:10.1038/ncb2926 Endothelial cells undergo rearrangements during angiogenic sprouting. Gerhardt and colleagues show that the flux in Notch signalling levels in individual cells of sprouting vessels results in differential dynamics of VE-cadherin at junctions to drive functional endothelial cell rearrangements during sprouting. They also find that differential VE-cadherin dynamics are affected in retinopathy and tumour vessels. See also: News and Views by Dejana & Lampugnani Septins promote F-actin ring formation by crosslinking actin filaments into curved bundles   pp322 - 334 Manos Mavrakis, Yannick Azou-Gros, Feng-Ching Tsai, José Alvarado, Aurélie Bertin et al. doi:10.1038/ncb2921 Lecuit and colleagues use Drosophila embryo cellularization as an in vivo model system, as well as in vitro reconstitution assays, to show that septin mutant embryos display defects in actin organization and that septins are able to crosslink, bundle and bend actin filaments into rings. Regulation of microtubule motors by tubulin isotypes and post-translational modifications   pp335 - 344 Minhajuddin Sirajuddin, Luke M. Rice and Ronald D. Vale doi:10.1038/ncb2920 Vale and colleagues report the distinct abilities of different tubulin isotypes and post-translational modifications to regulate different microtubule motors and their properties. See also: News and Views by Wehenkel & Janke A time- and matrix-dependent TGFBR3–JUND–KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies   pp345 - 356 Chun-Chao Wang, Sameer S. Bajikar, Leen Jamal, Kristen A. Atkins and Kevin A. Janes doi:10.1038/ncb2930 Janes and colleagues use organotypic 3D models, transcriptomic analyses, mathematical modelling and in vivo tumour data to show that single cells oscillate between two anticorrelated expression states defined by TGFBR3 and JUND. They show that this signalling circuit is controlled by the engagement of the extracellular matrix, and propose that dynamic changes in gene expression states might underlie breast tumour heterogeneity. See also: News and Views by Michor & Weaver Metabolic control of YAP and TAZ by the mevalonate pathway   pp357 - 366 Giovanni Sorrentino, Naomi Ruggeri, Valeria Specchia, Michelangelo Cordenonsi, Miguel Mano et al. doi:10.1038/ncb2936 Del Sal and colleagues demonstrate that the YAP and TAZ effectors of the Hippo pathway are under the control of the mevalonate pathway. They show that mutant p53 and SREBP-dependent activation of mevalonate signalling activates YAP and TAZ and promotes tumour formation in mice, a growth phenotype also conserved in Drosophila. Letters Top Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source   pp367 - 375 You-Ying Chau, Roberto Bandiera, Alan Serrels, Ofelia M. Martínez-Estrada, Wei Qing et al. doi:10.1038/ncb2922 Increased visceral adipose tissue has been associated with metabolic dysfunction but the origin of the progenitors that give rise to this tissue, and whether they are the same as the progenitors contributing to the protective subcutaneous adipose tissue, was unclear. Hastie and colleagues have found that Wt1-positive mesothelial cells contribute to visceral adipocytes. Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus   pp376 - 381 Christophe Guilluy, Lukas D. Osborne, Laurianne Van Landeghem, Lisa Sharek, Richard Superfine et al. doi:10.1038/ncb2927 Burridge and colleagues demonstrate that isolated nuclei respond to force by increasing their stiffness, and that this mechanical adaptation is mediated by emerin phosphorylation. Corrigenda Top Corrigendum: Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation   p382 Jun-Ichi Sakamaki, Accalia Fu, Courtney Reeks, Stephen Baird, Chantal Depatie et al. doi:10.1038/ncb2957 Corrigendum: Rho-directed forces in collective migration   p383 Peter Friedl, Katarina Wolf and Mirjam M. Zegers doi:10.1038/ncb2947 Errata Top Erratum: Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation   p382 Jun-Ichi Sakamaki, Accalia Fu, Courtney Reeks, Stephen Baird, Chantal Depatie et al. doi:10.1038/ncb2944 Erratum: Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells   p382 M. Reay, M. C. Parrini, O. Cochet-Escartin, B. Ladoux, A. Buguin et al. doi:10.1038/ncb2946 Erratum: MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells   p383 Wei-Lun Hwang, Jeng-Kae Jiang, Shung-Haur Yang, Tse-Shun Huang, Hsin-Yi Lan et al. doi:10.1038/ncb2951 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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