Molecular Systems Biology - New articles published - 1 Apr 2014

March 2014 | Volume 10, Number 3 Submit Table of Contents Articles Volume 10, Number 3 Articles Identification of anticancer drugs for hepatocellular carcinoma through personalized genome‐scale metabolic modeling Personalized GEMs for six hepatocellular carcinoma patients are reconstructed using proteomics data and a task‐driven model reconstruction algorithm. These GEMs are used to predict antimetabolites preventing tumor growth in all patients or in individual patients. Rasmus Agren, Adil Mardinoglu, Anna Asplund, Caroline Kampf, Mathias Uhlen, and Jens Nielsen Published online 19.03.2014 A chromatin structure‐based model accurately predicts DNA replication timing in human cells A mechanistic model predicts cell lineage‐specific DNA replication timing based on the location of DNase‐hypersensitivity data alone. With essentially no parameters to adjust for different cell types, the model is truly predictive even for cells where timing data are not available. Yevgeniy Gindin, Manuel S Valenzuela, Mirit I Aladjem, Paul S Meltzer, and Sven Bilke Published online 28.03.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.