The EMBO Journal Table of Contents for 13 January 2014; Vol. 33, No. 2

1 January 2014 | Volume 33, Number 2 Submit Table of Contents Have you seen? Articles Resource Corrigendum Volume 33, Number 2 Have you seen? PIAS adds methyl‐bias to HSC‐differentiation The SUMO E3‐ligase PIAS1 contributes to HSC‐maintenance respective differentiation by regulating DNMT‐recruitment to target gene promoters. Saghi Ghaffari Published online 13.01.2014 Short‐circuiting microtubule plus and minus end proteins in spindle positioning Interplay between γ‐TuRC and EB1 controls mitotic spindle positioning by affecting stability and dynamics of astral microtubules. Stephen L. Rogers Published online 13.01.2014 The benefits of aging: cellular senescence in normal development So far exclusively linked to pathological conditions, new studies place the onset of cellular senescence into the physiological context of organismal development. Ainhoa Pérez‐Garijo and Herman Steller Published online 21.12.2013 Articles PIAS1 SUMO ligase regulates the self‐renewal and differentiation of hematopoietic stem cells Novel genetic results establish the ubiquitin E3‐ligase PIAS1 as epigenetic regulator of HSC‐dormancy and lineage restriction by direct repression of Gata1. Bin Liu, Kathleen M. Yee, Samuel Tahk, Ryan Mackie, Cary Hsu, and Ke Shuai Published online 12.12.2013 γ‐Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning γ‐TuRCs gain an unexpected mitotic function in stabilizing astral microtubules, independent of their essential microtubule nucleation roles at centrosomes. Anaїs Bouissou, Christel Vérollet, Hélène de Forges, Laurence Haren, Yohanns Bellaїche, Franck Perez, Andreas Merdes, and Brigitte Raynaud‐Messina Published online 13.01.2014 EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis Inactive EGFR recruits IQGAP1 to the basolateral membrane of epithelial cells to ensure proper NuMA‐dependent mitotic spindle orientation. EGF‐EGFR signaling disrupts IQGAP1 polarization, causing spindle misorientation and affecting lumen formation in epithelial tubules. Inmaculada Bañón‐Rodríguez, Manuel Gálvez‐Santisteban, Silvia Vergarajauregui, Minerva Bosch, Arantxa Borreguero‐Pascual, and Fernando Martín‐Belmonte Published online 13.01.2014 Wnt‐induced transcriptional activation is exclusively mediated by TCF/LEF Integrated genome‐wide ChIP‐seq data in multiple cell types reveals that Tcf4 globally determines Wnt/beta‐catenin transcriptional programs. Jurian Schuijers, Michal Mokry, Pantelis Hatzis, Edwin Cuppen, and Hans Clevers Published online 10.01.2014 Resource Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting A novel Fluorescence Activated Synaptosome Sorting (FASS) approach allows for high‐resolution biochemical analyses of specific synapse subpopulations and identification of 163 proteins that are specifically enriched in FASS‐sorted synaptosomes. Christoph Biesemann, Mads Grønborg, Elisa Luquet, Sven P Wichert, Véronique Bernard, Simon R Bungers, Ben Cooper, Frédérique Varoqueaux, Liyi Li, Jennifer A Byrne, Henning Urlaub, Olaf Jahn, Nils Brose, and Etienne Herzog Published online 10.01.2014 Corrigendum Mfn2 modulates the UPR and mitochondrial function via repression of PERK Juan Pablo Muñoz, Saška Ivanova, Jana Sánchez‐Wandelmer, Paula Martínez‐Cristóbal, Eduard Noguera, Ana Sancho, Angels Díaz‐Ramos, María Isabel Hernández‐Alvarez, David Sebastián, Caroline Mauvezin, Manuel Palacín, and Antonio Zorzano Published online 13.01.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.