The EMBO Journal Table of Contents for 7 January 2014; Vol. 33, No. 1

1 January 2014 | Volume 33, Number 1 Submit Table of Contents Editorial Have you seen? Review Articles Volume 33, Number 1 Editorial EMBO Press – a new way to publish EMBO Press provides a platform for The EMBO Journal to publish papers that are more discoverable, accessible and optimized for sharing and promoting important research findings. Bernd Pulverer Published online 07.01.2014 Have you seen? Control not at initiation? Bah, humbug! The presence of rare codons in an mRNA can reduce translation elongation speed and make ribosome clearance of the start codon rate‐limiting for protein synthesis. William C. Merrick and Michael E. Harris Published online 21.12.2013 Lin28a – boost your energy for youthful regeneration Establishing Lin28 as metabolic regulator offers a fresh perspective on crucial mechanisms of age‐dependent regenerative capacity. Martin D. Burkhalter, Yohei Morita, and Karl Lenhard Rudolph Published online 19.12.2013 Review The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus Michal Schwartz and Kuti Baruch review the immunological processes involved in neuroinflammation and neurodegeneration, and how inflammation‐resolving cells are recruited to the CNS. Michal Schwartz and Kuti Baruch Published online 19.12.2013 Articles Translation elongation can control translation initiation on eukaryotic mRNAs Codon usage‐dependent ribosomal elongation speed can control translational output by securing fast ribosome clearance of the start codon. Highly expressed proteins preferentially harbour ‘fast codons’ downstream of the initiation site. Dominique Chu, Eleanna Kazana, Noémie Bellanger, Tarun Singh, Mick F Tuite, and Tobias von der Haar Published online 19.12.2013 Cell adhesion defines the topology of endocytosis and signaling Cells on micropatterned surfaces show asymmetric uptake of transferrin at adhesive areas that is dependent on the enrichment of clathrin and adaptor protein 2, and EGF at the dorsal side regulated by the actin cytoskeleton. Jean‐Philippe Grossier, Georgia Xouri, Bruno Goud, and Kristine Schauer Published online 23.12.2013 Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48‐linked ubiquitin chains Asymmetric interactions within an E2 enzyme homodimer facilitates ubiquitin positioning for assembly and subsequent en‐bloc transfer of linkage‐specific polyubiquitin chains. Weixiao Liu, Yongliang Shang, Yan Zeng, Chao Liu, Yanchang Li, Linhui Zhai, Pan Wang, Jizhong Lou, Ping Xu, Yihong Ye, and Wei Li Published online 23.12.2013 The Arabidopsis PEPR pathway couples local and systemic plant immunity Local microbial recognition involving PEPR pattern recognition receptors leads to a systemic immune response via the Salicylate and Jasmonate hormone signaling pathways. Annegret Ross, Kohji Yamada, Kei Hiruma, Misuzu Yamashita‐Yamada, Xunli Lu, Yoshitaka Takano, Kenichi Tsuda, and Yusuke Saijo Published online 12.12.2013 The mechanism of translation initiation on Type 1 picornavirus IRESs Viruses usurp a range of host genes to mediate efficient translation. The first in vitro reconstitution of initiation on picornavirus Type 1 IRESs reveals the set of translation factors minimally required for viral propagation. Trevor R Sweeney, Irina S Abaeva, Tatyana V Pestova, and Christopher U T Hellen Published online 12.12.2013   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.