EMBO reports Table of Contents for 1 January 2014; Vol. 15, No. 1

1 January 2014 | Volume 15, Number 1 Submit Table of Contents Editorial Opinion Hot off the Press Science & Society Reviews Scientific Reports Retraction Volume 15, Number 1 Editorial Thinking outside the TATA box Interest has recently revived in what was once considered the ‘non‐coding’ portion of the genome. Howy ponders whether we should widen our horizons still further. Howy Jacobs Published online 21.12.2013 A new endeavour EMBO will launch EMBO Press in December 2013 as an umbrella identity for its four journals. EMBO Reports will be integral to the diversity of content offered by the EMBO Press family, and to the further implementation and improvement of EMBO's fair and transparent editorial process. Published online 07.01.2014 Variety, complexity, specificity… infinitively seductive ubiquitin This issue of EMBO reports features our “Ubiquitylation: mechanism and functions” Review Series, and includes a multi‐interview and a review on the role of ubiquitin in immunity. The series includes five other reviews on different aspects of this exciting field. Nonia Pariente Published online 21.12.2013 Opinion Pesticides and bees The European Commission's ban on neonicotinoid pesticides in the EU and the resulting lawsuit from Bayer and Syngenta, two major producers, highlights the need for better regulatory guidelines and environmental risk assessment of agricultural pesticides for market approval. Laura Maxim and Gérard Arnold Published online 19.12.2013 Hot off the Press The many faces of mitophagy Two articles in EMBO reports, by the Przedborski and Ganley groups, show that processed, cytoplasmic PINK1 inhibits mitophagy, whereas depletion of cellular iron levels stimulates a new PINK1/Parkin‐independent mitophagy pathway. Rachael M Ivatt and Alexander J Whitworth Published online 07.01.2014 Science & Society The seven wonders of ubiquitin: a multi‐interview: Personal insights into the ubiquitin field This is an interview with the senior authors of the “Ubiquitylation: mechanism and function” review series, as well as I. Dikic and M. Rape. Coming from various fields and at different career stages, they paint the picture of the current state of the ubiquitin field. Published online 07.01.2014 Internet addiction disorder and youth: There are growing concerns about compulsive online activity and that this could impede students' performance and social lives Although not officially recognized as a disorder, obsessive use of the Internet is a very real problem that can negatively impact health, well being, social life and academic performance. But what is it and how should we treat it? Patricia Wallace Published online 07.01.2014 Conservation, human values and democracy: What can turn humankind from the path of environmental exploitation and destruction? Humans are aware of the precarious state of the environment, but we show little inclination to address the problem. Because we fail to grasp our role as individuals in Nature, strategies for a more sustainable future can only come from advances in awareness we make as societies. Valentí Rull Published online 07.01.2014 ‘Kicking the can’: science, Congress and a Ponzi scheme: Even if US Congress finally approved a tentative budget, scientists worry that the ongoing budget fights will damage US research in the longer term After the latest forced shutdown of the US government by Congress in October, scientists are concerned that the ongoing budget fights in Washington will hurt US research in the longer term. Howard Wolinsky and Rita Rubin Published online 07.01.2014 Motivating teams requires attention to individuals: The growing body of social research on how to motivate and manage teamwork attracts increasing attention from research institutions and funding agencies Managing and motivating teams is gaining increasing importance in academic research as international and interdisciplinary teams become more common. Philip Hunter Published online 07.01.2014 Reviews The IκB kinase complex in NF‐κB regulation and beyond The IKK complex is the central hub for NF‐κB activation, but many NF‐κB independent substrates highlight the diversity of IKK function and crosstalks with other pathways. Structural information has recently shed light into IKK architecture, activation and substrate recognition. Michael Hinz and Claus Scheidereit Published online 27.12.2013 “Ubiquitylation: mechanism and functions” Review series Ubiquitin in the immune system Ubiquitination and deubiquitination are crucial regulatory events for immune system development and its correct function. This Review analyzes how ubiquitin impacts innate host defense mechanisms and self‐tolerance. Julia Zinngrebe, Antonella Montinaro, Nieves Peltzer, and Henning Walczak Published online 27.12.2013 Scientific Reports Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion The fate of normal intestinal stem cells is determined through neutral competition. This study shows that when oncogenic K‐Ras mutations arise, biased stem cell competition leads to a drift towards mutant crypt expansion that could be the underlying cause of field cancerization. Hugo J. Snippert, Arnout G. Schepers, Johan H. van Es, Benjamin D. Simons, and Hans Clevers Published online 12.12.2013 Extensive regulation of the non‐coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2 Integrated genomic analysis of the cellular response to hypoxia using massively parallel sequencing shows profound regulation of the non‐coding as well as the coding transcriptome. This report also identifies the release of pre‐bound promoter‐paused RNApol2 by hypoxia‐inducible factor (HIF) as a major effector of this transcriptional response. Hani Choudhry, Johannes Schödel, Spyros Oikonomopoulos, Carme Camps, Steffen Grampp, Adrian L Harris, Peter J Ratcliffe, Jiannis Ragoussis, and David R Mole Published online 21.12.2013 HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia This study shows that, in the presence of VHL, USP8 deubiquitination of HIF1α is essential to maintain ciliogenesis. Importantly, this study underscores the importance of maintaining a basal pool of HIF1α in normoxia for endosome‐trafficking‐mediated ciliogenesis. Albino Troilo, Irina Alexander, Sarah Muehl, Daniela Jaramillo, Klaus‐Peter Knobeloch, and Wilhelm Krek Published online 30.12.2013 Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy PINK1, mutants of which are associated with Parkinson, is thought to function in mitochondria. Here, PINK1 is shown to be exported into the cytosol after cleavage, where it binds Parkin, inhibiting its mitochondrial recruitment and preventing mitophagy. Maja A. Fedorowicz, Rosa L. A. de Vries‐Schneider, Cornelia Rüb, Dorothea Becker, Yong Huang, Chun Zhou, Dana M. Alessi Wolken, Wolfgang Voos, Yuhui Liu, and Serge Przedborski Published online 12.12.2013 Endosomal transport of septin mRNA and protein indicates local translation on endosomes and is required for correct septin filamentation Endosomes receive cargo from membrane compartments for intracellular transport. In vivo evidence suggests a novel mechanism of cargo loading, whereby endosome‐coupled translation of septin mRNA loads endosomes with septin protein for delivery to cellular growth poles. Sebastian Baumann, Julian König, Janine Koepke, and Michael Feldbrügge Published online 12.12.2013 Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors This study shows that metabotropic glutamate receptors (mGlu1) trigger the opening of orphan GluD2 delta glutamate receptors, thus highlighting a novel gating mechanism for ionotropic glutamate receptors that provides synapses with features very different from the classical fast transmission. Visou Ady, Julie Perroy, Ludovic Tricoire, Claire Piochon, Selma Dadak, Xiaoru Chen, Isabelle Dusart, Laurent Fagni, Bertrand Lambolez, and Carole Levenes Published online 12.12.2013 Obesity resistance and deregulation of lipogenesis in Δ6‐fatty acid desaturase (FADS2) deficiency Systemic absence of ω3‐ and ω6‐polyunsaturated fatty acid (PUFA) in delta‐6‐fatty acid desaturase deficiency (fads2−/−) causes pleiotropy, of which obesity resistance and deregulation of lipogenesis are described here. Wilhelm Stoffel, Ina Hammels, Britta Jenke, Erika Binczek, Inga Schmidt‐Soltau, Susanne Brodesser, Margarete Odenthal, and Mario Thevis Published online 30.12.2013 Retraction Retraction: ‘Ubiquitin‐specific protease 4 is inhibited by its ubiquitin‐like domain’ by MP Luna‐Vargas, AC Faesen, WJ van Dijk, M Rape, A Fish, TK Sixma Published online 07.01.2014   Unsubscribe from or edit your subscription for this service. 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