Nature Reviews Molecular Cell Biology contents January 2014 Volume 15 Number 1 pp 1-74

TABLE OF CONTENTS
January 2014 Volume 15 Number 1
Impact Factor 29.852 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: DNA damage Cell death and autophagy  Featured article: Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration Nick Barker
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RESEARCH HIGHLIGHTS Top RNA metabolism: The CBC social network p1 | doi:10.1038/nrm3718 The formation of diverse CBC subcomplexes determines RNA fate by connecting 3' end formation, degradation and export. PDF Protein metabolism: A channel for ERAD p2 | doi:10.1038/nrm3725 Der1 ensures transit of misfolded substrates for ER-associated degradation. PDF RNA: The (methylation) reader p2 | doi:10.1038/nrm3727 YTHDF2 is a 'reader' protein that recognizes m6A-containing mRNAs and targets them for degradation. PDF Cytoskeleton: Remodelling the FtsZ network p3 | doi:10.1038/nrm3724 FtsA has a dual role in FtsZ network assembly and rearrangement. PDF Metabolism: Young again with Lin28 p4 | doi:10.1038/nrm3715 Lin28a enhances tissue repair by increasing oxidative metabolism. PDF Cell cycle: Forming healthy attachments p4 | doi:10.1038/nrm3720 RZZ interacts with NDC-80 to inhibit the formation of end-coupled microtubule attachments. PDF JOURNAL CLUB Chromosomes: now in 3D! p6 | doi:10.1038/nrm3717 Three-dimensional trajectories of chromatin have been visualized by Hi-C. PDF Cell death: E2Ffects on mitochondria p6 | doi:10.1038/nrm3726 The role of E2F transcription factors in apoptosis depends on effects on mitochondrial function, as well as the transcription of pro-apoptotic genes. PDF IN BRIEF Development: Developmentally programmed senescence | Translation: When ribosomes don't stop | Centrosomes: A new partner for BRCA1–BARD1 | DNA Repair: A mediator for DNA repair | Cytokinesis: Ringfenced from damage | Protein folding: A late need for oxygen PDF Molecular Cell Biology JOBS of the week Postdoc in skin biolog, molecular biology and cell biology Stony Brook University Postdoctoral Position at The Scripps Research Institute The Scripps Research Institute Postdoctoral Research Opportunities in Neuronal Cell Signaling Temple University and Shriners Pediatric Research Center Cell / Molecular Engineering Massachusetts General Hospital & Harvard Medical School Postdoctoral Fellow in Biomedical Engineering Queensland University of Technology - Translational Research Institute More Science jobs from
REVIEWS		Top
Article series: DNA damage Double-strand break repair: 53BP1 comes into focus Stephanie Panier & Simon J. Boulton p7 | doi:10.1038/nrm3719 The function of 53BP1 in DNA double-strand break repair is multifaceted, and includes mediator and effector roles. New appreciation of how it is recruited to damaged chromatin, and how it exerts control on pathway choice, has cemented the central role of 53BP1 in genome stability maintenance. Abstract | Full Text | PDF
Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration Nick Barker p19 | doi:10.1038/nrm3721 Renewal and repair of the intestinal epithelium depend on small populations of intestinal stem cells. Specific markers for these stem cells have recently been discovered. This advance, together with the development of new technologies to track endogenous stem cell activity and to generate new epithelia ex vivo, is shedding light on the mechanisms underlying intestinal stem cell-driven homeostasis and regeneration. Abstract | Full Text | PDF | Supplementary information
Cell intercalation from top to bottom Elise Walck-Shannon & Jeff Hardin p34 | doi:10.1038/nrm3723 The mechanisms that drive cell intercalation and thereby cell rearrangements during morphogenesis vary in different developmental contexts and species. Comparison of the key control steps in each case has improved our understanding of the specific parts played by adhesion and cytoskeletal changes, as well as planar cell polarity signalling. Abstract | Full Text | PDF
Article series: Cell death and autophagy Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy Peter E. Czabotar, Guillaume Lessene, Andreas Strasser & Jerry M. Adams p49 | doi:10.1038/nrm3722 Interactions on the mitochondrial outer membrane between members of the three subgroups of the BCL-2 protein family set the apoptotic threshold. Recent structural insights into the molecular mechanisms of this commitment to apoptosis are guiding the development of new therapeutics for cancer, and potentially also autoimmune and infectious diseases. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: Cell death and autophagy The return of the nucleus: transcriptional and epigenetic control of autophagy Jens Fullgrabe, Daniel J. Klionsky & Bertrand Joseph p65 | doi:10.1038/nrm3716 Autophagy was thought to be a purely cytosolic event. However, recent data highlight a role for the nucleus in autophagy regulation, showing that a complex network of histone modifications, microRNAs and transcription factors also control this process. Abstract | Full Text | PDF
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