Nature Reviews Immunology Contents January 2014 Volume 14 Number 1 pp 1-59

TABLE OF CONTENTS
January 2014 Volume 14 Number 1
Impact Factor 33.129 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Human memory T cells: generation, compartmentalization and homeostasis Donna L. Farber, Naomi A. Yudanin & Nicholas P. Restifo
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Nature Collections  LIGHT-SHEET MICROSCOPY  The use of a planar sheet of light for illumination in light-sheet fluorescence microscopy allows researchers to image sample volumes faster than is possible with other current methods, while limiting light dosage. A collection of articles from Nature Methods, Nature Communications and Nature Reviews Molecular Cell Biology provides a brief overview of this exciting imaging technology and the biological research applications that it makes possible. Produced with support from: Carl Zeiss Microscopy
RESEARCH HIGHLIGHTS Top Tumour immunology: Anticancer drugs need bugs p1 | doi:10.1038/nri3591 Antibiotics disrupt the microflora and impair the efficacy of cancer therapies. PDF Mucosal immunology: Bacteria get TReg cells into shape p2 | doi:10.1038/nri3583 The bacterial by-product butyrate affects histone acetylation of Foxp3 and thereby promotes peripheral TReg cell differentiation. PDF Innate immunity: A surprise regulator of plasmacytoid DCs p2 | doi:10.1038/nri3590 VEGFR2 expression is required for the survival and function of plasmacytoid dendritic cells. PDF Neonatal immunity: Hush-a by baby p4 | doi:10.1038/nri3584 Neonatal erythroid cells actively suppress immune responses against microbes. PDF Immune evasion: Staphylococcus slips through the net p4 | doi:10.1038/nri3585 Two new Staphylococcus aureus virulence factors convert neutrophil extracellular traps (NETs) to deoxyadenosine, which triggers macrophage apoptosis. PDF Regulatory T cells: Going over to the dark side p5 | doi:10.1038/nri3586 Bona fide TReg cells can become unstable during an autoimmune response. PDF Innate immunity: Making mice more human the TLR8 way p6 | doi:10.1038/nri3587 The generation of TLR8 transgenic mice reveals a role for this receptor in autoimmune disease. PDF Immunometabolism: Regulatory B cells weigh in p6 | doi:10.1038/nri3588 Interleukin-10-producing B cells in adipose tissues limit obesity-associated inflammation. PDF Macrophages: Early antifungal defence in kidneys p6 | doi:10.1038/nri3589 Control of systemic candidiasis depends on CX3CR1-mediated renal macrophage survival. PDF IN BRIEF Macrophages: Recruiting neutrophils to skin infection | T cell memory: The effect of ageing on CD8+ T cells | Regulatory T cells: Make friends with the fungi | Tumour immunology: Tumour-bearing mice feel the cold | HIV: Mechanisms of T cell polyfunctionality | Tumour immunology: Boosting macrophage responses to brain tumours PDF Immunology JOBS of the week Postdoctoral Associate University of Rochester Medical Center Postdoctoral fellow Medical University of South Carolina Postdoctoral Research Fellow University of Minnesota - Twin Cities Experimental hematology - focus on leukemia Lund University Post-doctoral fellow FAPESP - São Paulo Research Foundation More Science jobs from Immunology EVENT 2nd European Conference of Microbiology and Immunology 06.06.14 Berlin, Germany More science events from
REVIEWS		Top
NOD proteins: regulators of inflammation in health and disease Dana J. Philpott, Matthew T. Sorbara, Susan J. Robertson, Kenneth Croitoru & Stephen E. Girardin p9 | doi:10.1038/nri3565 Nucleotide oligomerization domain-containing protein 1 (NOD1) and NOD2 are pattern-recognition receptors that detect bacterial peptidoglycan. Signalling through NODs initiates a variety of effector immune responses that seem to be crucial for maintaining immune homeostasis with the host microbiota. Indeed, mutations in NOD1 and NOD2 are associated with both intestinal and extra-intestinal disease. This Review summarizes our current understanding of the NODs. Abstract | Full Text | PDF
Human memory T cells: generation, compartmentalization and homeostasis Donna L. Farber, Naomi A. Yudanin & Nicholas P. Restifo p24 | doi:10.1038/nri3567 Most of our understanding of immunological memory comes from studies in mice. However, these studies cannot recapitulate the exposure to numerous diverse pathogens that occurs over decades in humans. But, as reviewed here, recent studies focusing on human memory T cells are revealing important features of these cells, including subset heterogeneity and spatial compartmentalization. Abstract | Full Text | PDF
Regulation of type I interferon responses Lionel B. Ivashkiv & Laura T. Donlin p36 | doi:10.1038/nri3581 This Review describes the intricate signalling and epigenetic mechanisms that regulate cellular responses to type I interferons. The authors also discuss how persistent interferon-mediated signalling can have detrimental outcomes in autoimmune disease and chronic infections. Abstract | Full Text | PDF
PERSPECTIVES		Top
TIMELINE Concepts of tissue injury and cell death in inflammation: a historical perspective David Wallach, Tae-Bong Kang & Andrew Kovalenko p51 | doi:10.1038/nri3561 New advances in our understanding of the molecular mechanisms linking cell death and inflammation are discussed in the context of historical studies from the past two centuries. Abstract | Full Text | PDF
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