Nature Review Cancer contents January 2014 Volume 14 Number 1 pp 1-70

TABLE OF CONTENTS
January 2014 Volume 14 Number 1		Advertisement
Impact Factor 35 *	In this issue Comment Research Highlights Reviews Perspectives Correspondence Also this month Article series: Clinical insights  Featured article: PAK signalling during the development and progression of cancer Maria Radu, Galina Semenova, Rachelle Kosoff & Jonathan Chernoff	The story of Leukemia research is being re-written - one droplet at a time. See how droplet digital PCR gives scientists the power to detect what was previously undetectable. Watch Video >
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In this issue p1 | doi:10.1038/nrc3654 Full Text
Article series: Clinical insights Comment: Cancer of unknown primary site: still an entity, a biological mystery and a metastatic model F. Anthony Greco p3 | doi:10.1038/nrc3646 Cancer of unknown primary site is both a challenging clinical problem and a disease that provides potential insight into the mechanisms that underlie early metastasis. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Stem cells: Competitive behaviour of cancer mutations p5 | doi:10.1038/nrc3652Two new studies characterize the effects of cancer mutations on stem cell niches in vivo. PDF Drug resistance: Making a point p6 | doi:10.1038/nrc3649 Three groups have sequenced samples of ER-positive and hormone therapy-resistant breast cancers and found point mutations in ESR1, the gene encoding ERα. PDF Therapeutics: Delving deeper into resistance p7 | doi:10.1038/nrc3653 Five recent papers have looked more closely at mechanisms that underlie resistance to inhibitors of the ERK MAPK pathway in melanomas that have the BRAF-V600E mutation and have shown that several mechanisms probably contribute to resistance, even within the same patient. PDF Oncogenes: Direct hit on mutant RAS p8 | doi:10.1038/nrc3650 A paper in Nature reports the design of small molecules that can irreversibly bind to and block the activity of oncogenic KRAS-G12C, but not wild-type KRAS. PDF Signalling: A new target for p53-null tumours p8 | doi:10.1038/nrc3651 A new study by Emerling and colleagues has shown that phosphatidylinositol 5-phosphate 4-kinase type-2α (PIP4K2α) and PIP4K2β are essential for the growth of p53-null cells and may represent a pharmaceutical target for cancers that have non-functional p53. PDF Tumour microenvironment: Losing your SPARC p10 | doi:10.1038/nrc3657 Mario Colombo and colleagues have found that disruption of the stroma in the spleen and lymph nodes can transform autoimmune B cells. PDF Tumour microenvironment: Bacterial balance affects cancer treatment p10 | doi:10.1038/nrc3658 Two new studies in mice have shown that disrupting the microbial balance in the gut through the use of antibiotics can affect the response to cancer therapy. PDF IN BRIEF DNA repair: Double take | Therapeutics: Amplifying a response | Signalling: A change of state leads to rewiring | Multiple myeloma: Destruction of Ikaros | Epigenetics: Context-dependent role of SWI/SNF | microRNA: Self-regulated transcription | Metabolism: Cholesterol promotes breast cancer growth | Epigenetics: Senescent cells: poised for cancer | Biomarkers: TERT marks recurrence of urothelial cancer | Microenvironment: Thermal stress in mice PDF Cancer JOBS of the week Postdoctoral Position in Epigenetic Mechanisms in Cancer Cancer Research Center of Lyon (CRCL) Post-Docs in Cell Death Signaling & Cancer Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt Postdoctoral Scholar in Cancer Research Mitchell Cancer Institute at University of South Alabama Post-doctoral Training Fellow, Proteomics and Cancer Biology Institute of Cancer Research (ICR) Helmholtz International Graduate School in Cancer Biology German Cancer Research Center (DKFZ) More Science jobs from Cancer EVENT American Association for Cancer Research Annual Meeting 2014 05.04.14 San Diego, USA More science events from
REVIEWS		Top
PAK signalling during the development and progression of cancer Maria Radu, Galina Semenova, Rachelle Kosoff & Jonathan Chernoff p13 | doi:10.1038/nrc3645 p21-activated kinases (PAKs) have important roles in several oncogenic signalling pathways. How are PAKs activated in cancer, what are their key substrates, and how might small molecules against these enzymes best be developed and deployed for the treatment of cancer? Abstract | Full Text | PDF
Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy Wen Zhou & Joyce M. Slingerland p26 | doi:10.1038/nrc3622 This Review discusses the elucidation of mechanisms whereby oestrogen drives both oestrogen receptor-α transactivation and receptor proteolysis, which might have important therapeutic implications not only for breast cancer but also for other hormone-regulated cancers. Abstract | Full Text | PDF
The roles of K+ channels in cancer Luis A. Pardo & Walter Stühmer p39 | doi:10.1038/nrc3635 Potassium channels are transmembrane proteins that selectively facilitate the flow of potassium ions down an electrochemical gradient. Their roles in cell proliferation, angiogenesis and cell migration have only recently been assessed. Thus, the potential importance of these channels for tumour biology is only now becoming evident. Abstract | Full Text | PDF
Tetraspanin proteins promote multiple cancer stages Martin E. Hemler p49 | doi:10.1038/nrc3640 This Review discusses recent evidence, particularly from mouse models, showing that some tetraspanin proteins have important roles in tumour initiation, promotion, metastasis and angiogenesis, and that they might therefore be valid therapeutic targets. Abstract | Full Text | PDF
PERSPECTIVES		Top
SCIENCE AND SOCIETY Survivors of childhood and adolescent cancer: life-long risks and responsibilities Leslie L. Robison & Melissa M. Hudson p61 | doi:10.1038/nrc3634 Although survival rates for most paediatric cancers have improved at a remarkable pace over the past four decades, the vast majority of these cancer survivors will have at least one chronic health condition by 40 years of age. How can we best understand and treat the long-term morbidity and mortality that is associated with currently successful treatments? Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: Mechanistic links between COPD and lung cancer: a role of microRNA let-7? Jae Il Shin & Guy G. Brusselle p70 | doi:10.1038/nrc3477-c1 Full Text | PDF
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