Nature Immunology Contents: January 2014 Volume 15 pp 1 - 109

TABLE OF CONTENTS January 2014 Volume 15, Issue 1 Obituaries Commentary News and Views Research Highlights Review Articles Resource Addendum Corrigenda Erratum Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement nature.com webcasts Macmillan Science Communication presents a custom webcast series: Drugging the Human Methylome Two independent, but complimentary, webcasts and live Q & A's broadcasting on:  21 January   23 January  Sponsored by:     Obituaries Top Leonard A. Herzenberg 1931-2013   p1 Garry P Nolan doi:10.1038/ni.2791 Michael S. Neuberger 1953-2013   p2 Cristina Rada doi:10.1038/ni.2788 Commentary Top Universal influenza virus vaccines: need for clinical trials   pp3 - 5 Florian Krammer and Peter Palese doi:10.1038/ni.2761 To overcome the limitations of seasonal influenza virus vaccines and enhance our pandemic preparedness, influenza virus vaccines that provide universal and long-lasting protection are needed. News and Views Top Outflanking HCV   pp6 - 8 Zhigang Tian doi:10.1038/ni.2783 Studies have linked polymorphisms near the gene encoding interferon-λ3 (IFNL3) to clearance of hepatitis C virus (HCV). One such favorable polymorphism operates by stabilizing IFNL3 mRNA via a decrease in AU-rich element-mediated decay as well as the binding of HCV-induced host microRNAs. See also: Article by McFarland et al. A new VEGF connection between two old neighbors   pp8 - 9 Marina Cella and Giorgio Trinchieri doi:10.1038/ni.2786 Plasmacytoid dendritic cells express the microRNA miR-126, which controls their survival and effector functions via the receptor VEGFR2. See also: Article by Agudo et al. Neutrophil recruitment: perivascular macrophages 'duke it out' with Staphylococcus aureus   pp10 - 11 Francis W Luscinskas doi:10.1038/ni.2793 Control of infection with Staphylococcus aureus relies on the production of neutrophil-recruiting chemokines by perivascular macrophages. S. aureus counterattacks by secreting α-hemolysin, which lyses tissue macrophages. See also: Article by Abtin et al. Innate TCRs: single use only   pp12 - 13 Tom Cupedo and Janneke N Samsom doi:10.1038/ni.2792 Innate-like T cells are dependent on triggering via the T cell antigen receptor (TCR) for development but subsequently actively alter their TCR responsiveness to allow an innate mode of activation that no longer requires TCR signaling. See also: Article by Wencker et al. Immunology JOBS of the week Postdoctoral Appointee - Immunology Sandia National Laboratories Postdoctoral fellow in mucosal immunology and microbiome University of Colorado Anschutz Medical Campus Postdoctoral Scientist / Immunology New York University (NYU) Medical Center Postdoctoral Fellow (Tumour Immunology) National University of Singapore (NUS) Assistant Profesor for an Immunology Laboratory Hokkaido University More Science jobs from Immunology EVENT The Immunology of Ageing 24th Feb 2014 London, UK More science events from Research Highlights Top Regulating STING | Thymic threshold gatekeeper | A window of allergy | Slipping the NET | Unstable Foxp3 | Autoreactive T cell trafficking Review Top NF-κB control of T cell development   pp15 - 25 Steve Gerondakis, Thomas S Fulford, Nicole L Messina and Raelene J Grumont doi:10.1038/ni.2785 The transcription factor NF-κB is required for T cell effector function. Gerondakis and colleagues discuss the role of NF-κB in T cell development. Articles Top Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus   pp27 - 35 Cyrille Ramond, Claire Berthault, Odile Burlen-Defranoux, Ana Pereira de Sousa, Delphine Guy-Grand et al. doi:10.1038/ni.2782 The identity of the thymus-seeding progenitor cells has been a matter of debate. Cumano and colleagues report that early and late embryonic progenitor cells differ in their T cell-B cell lineage potential and capacity for population expansion and differentiation. Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development   pp36 - 44 Netali Ben Baruch-Morgenstern, Dana Shik, Itay Moshkovits, Michal Itan, Danielle Karo-Atar et al. doi:10.1038/ni.2757 Paired immunoglobulin-like receptors (PIRs) recognize β2-microglobulin. Munitz and colleagues show that PIR-A and PIR-B have opposing roles in eosinophil development in response to interleukin 5 in the bone marrow. Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection   pp45 - 53 Arby Abtin, Rohit Jain, Andrew J Mitchell, Ben Roediger, Anthony J Brzoska et al. doi:10.1038/ni.2769 Weninger and colleagues show that perivascular macrophages are critical for neutrophil migration into skin infected with Staphylococcus aureus and that the pathogen uses hemolysin-dependent killing of these cells as an immune evasion strategy. See also: News and Views by Luscinskas The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids   pp54 - 62 Judith Agudo, Albert Ruzo, Navpreet Tung, Hélène Salmon, Marylène Leboeuf et al. doi:10.1038/ni.2767 Plasmacytoid dendritic cells produce copious amounts of type I interferon in response to viral infection. Brown and colleagues show that the homeostasis and function of these cells are regulated by the microRNA miR-126. See also: News and Views by Cella & Trinchieri GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses   pp63 - 71 Hao-Sen Chiang, Yun Zhao, Joo-Hye Song, Song Liu, Ninghai Wang et al. doi:10.1038/ni.2766 RIG-I-like receptors are important inducers of innate immunity. Reinecker and colleagues find that activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1 is essential for sensing of foreign RNA by these receptors. The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs   pp72 - 79 Adelle P McFarland, Stacy M Horner, Abigail Jarret, Rochelle C Joslyn, Eckart Bindewald et al. doi:10.1038/ni.2758 Polymorphisms near genes encoding members of the IFN-λ family are associated with susceptibility or resistance to hepatitis C virus. Savan and colleagues show that differences in the stability of transcripts of those genes underlie the mechanism of resistance to that virus. See also: News and Views by Tian Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness   pp80 - 87 Melanie Wencker, Gleb Turchinovich, Rafael Di Marco Barros, Livija Deban, Anett Jandke et al. doi:10.1038/ni.2773 T cell hyporesponsiveness is generally framed in terms of tolerance induction. Hayday and colleagues show that attenuating TCR responsiveness is also critical for the development of innate-like T cells that mediate the surveillance of dysregulated tissues. See also: News and Views by Cupedo & Samsom Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency   pp88 - 97 Carrie L Lucas, Hye Sun Kuehn, Fang Zhao, Julie E Niemela, Elissa K Deenick et al. doi:10.1038/ni.2771 Lymphocyte function is regulated by phosphatidylinositol-dependent pathways. Uzel and colleagues identify a cohort of immunodeficient patients with hyperactive phosphatidylinositol-3-OH kinase activity due to mutant p110δ subunits, which results in enhanced senescence of cells of the immune system. Resource Top Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice   pp98 - 108 Payal B Watchmaker, Katharina Lahl, Mike Lee, Dirk Baumjohann, John Morton et al. doi:10.1038/ni.2768 Dendritic cells (DCs) that orchestrate mucosal immunity have been studied in mice. Lahl and colleagues characterize human gut DC populations and define their relationship to previously described human and mouse DCs. Addendum Top Addendum: Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production   p109 Hendrik Poeck, Michael Bscheider, Olaf Gross, Katrin Finger, Susanne Roth et al. doi:10.1038/ni0114-109a Corrigenda Top Corrigendum: Aiolos promotes TH17 differentiation by directly silencing Il2 expression   p109 Francisco J Quintana, Hulin Jin, Evan J Burns, Meghan Nadeau, Ada Yeste et al. doi:10.1038/ni0114-109b Corrigendum: Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation   p109 Linda V Sinclair, Julia Rolf, Elizabeth Emslie, Yun-Bo Shi, Peter M Taylor et al. doi:10.1038/ni0114-109c Corrigendum: TH2, allergy and group 2 innate lymphoid cells   p109 Paula Licona-Limón, Lark Kyun Kim, Noah W Palm and Richard A Flavell doi:10.1038/ni0114-109d Erratum Top Erratum: Research Highlight: Latent enhancement   p109 Zoltan Fehervari doi:10.1038/ni0114-109e Top Advertisement Nature Biotechnology FREE POSTER  Antibody-drug conjugates for cancer therapy  Several antibody-drug conjugates have been approved for clinical use in a variety of solid and hematological tumors, with many more in human testing. 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