The EDGE

Unity in Action

Barbara A Gilchrest, Editor

J Invest Dermatol 2014 134: 1-2; 10.1038/jid.2013.442

Who Wrote That?

Barbara A Gilchrest Editor and Elizabeth N Blalock Managing Editor

J Invest Dermatol 2014 134: 3-4; 10.1038/jid.2013.441

Clinical Snippets

J Invest Dermatol 2014 134: 5; 10.1038/jid.2013.454

BJD Editor's Choice

J Invest Dermatol 2014 134: 6; 10.1038/jid.2013.455

Editors' Picks

J Invest Dermatol 2014 134: 7; 10.1038/jid.2013.456

Research Techniques Made Simple

Transgenic Mouse Technology in Skin Biology: Generation of Complete or Tissue-Specific Knockout Mice

Lukas Scharfenberger, Tina Hennerici, Gbor Kirly, Sophie Kitzmüller, Marigje Vernooij and Julia G. Zielinski

J Invest Dermatol 2014 134: e16; 10.1038/jid.2013.457

JID VisualDx Quiz

JID VisualDx Quiz: January 2014

Sonal Choudhary and Robert S Kirsner

J Invest Dermatol 2014 134: e12; 10.1038/jid.2013.458

Commentaries

A New Light on an Old Disease: Adhesion Signaling in Pemphigus Vulgaris

Arnaud Galichet, Luca Borradori and Eliane J Müller

J Invest Dermatol 2014 134: 8-10; 10.1038/jid.2013.439

Dermatological Therapy by Topical Application of Non-Pathogenic Bacteria

Teruaki Nakatsuji and Richard L Gallo

J Invest Dermatol 2014 134: 11-14; 10.1038/jid.2013.379

Hippo: Hungry, Hungry for Melanoma Invasion

Ileine M Sanchez and Andrew E Aplin

J Invest Dermatol 2014 134: 14-16; 10.1038/jid.2013.372

The Impact of MITF on Melanoma Development: News from Bench and Bedside

Elisabeth M Roider and David E Fisher

J Invest Dermatol 2014 134: 16-17; 10.1038/jid.2013.390

Perspective

Heterogeneity of Response to Biologic Treatment: Perspective for Psoriasis

Emily Edson-Heredia, Kimberly L Sterling, Carlos I Alatorre, Gebra Cuyun Carter, Rosirene Paczkowski, Victoria Zarotsky and Tomoko Maeda-Chubachi

J Invest Dermatol 2014 134: 18-23; advance online publication, August 6, 2013; 10.1038/jid.2013.326

Original Articles

APPENDAGES

Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis

Michael W Hughes, Ting-Xin Jiang, Sung-Jan Lin, Yvonne Leung, Krzysztof Kobielak, Randall B Widelitz and Cheng M Chuong

J Invest Dermatol 2014 134: 24-32; advance online publication, June 21, 2013; 10.1038/jid.2013.283

Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles

Silvia Vidali, Jana Knuever, Johannes Lerchner, Melanie Giesen, Tamás Bíró, Matthias Klinger, Barbara Kofler, Wolfgang Funk, Burkhard Poeggeler and Ralf Paus

J Invest Dermatol 2014 134: 33-42; advance online publication, June 27, 2013; 10.1038/jid.2013.286

CLINICAL RESEARCH

Non-Melanoma Skin Cancer Incidence and Impact of Skin Cancer Screening on Incidence

Nora Eisemann, Annika Waldmann, Alan C Geller, Martin A Weinstock, Beate Volkmer, Ruediger Greinert, Eckhard W Breitbart and Alexander Katalinic

J Invest Dermatol 2014 134: 43-50; advance online publication, July 22, 2013; 10.1038/jid.2013.304

Warm, Humid, and High Sun Exposure Climates Are Associated with Poorly Controlled Eczema: PEER (Pediatric Eczema Elective Registry) Cohort, 2004–2012

Michael R Sargen, Ole Hoffstad and David J Margolis

J Invest Dermatol 2014 134: 51-57; advance online publication, June 17, 2013; 10.1038/jid.2013.274

CONNECTIVE TISSUE

Regeneration of Human Dermis by a Multi-Headed Peptide

Joan Attia-Vigneau, Christine Terryn, Sandrine Lorimier, Jerome Sandre, Frank Antonicelli and William Hornebeck

J Invest Dermatol 2014 134: 58-67; advance online publication, June 28, 2013; 10.1038/jid.2013.290

IMMUNOLOGY/INFECTION

MAPKAP Kinase 2 (MK2)-Dependent and -Independent Models of Blister Formation in Pemphigus Vulgaris

Xuming Mao, Hong Li, Yasuyo Sano, Matthias Gaestel, Jin Mo Park and Aimee S Payne

J Invest Dermatol 2014 134: 68-76; advance online publication, June 27, 2013; 10.1038/jid.2013.224

Blocking Von Willebrand Factor for Treatment of Cutaneous Inflammation

Carina Hillgruber, Annika K. Steingräber, Birgit Pöppelmann, Cécile V. Denis, Jerry Ware, Dietmar Vestweber, Bernhard Nieswandt, Stefan W Schneider and Tobias Goerge

J Invest Dermatol 2014 134: 77-86; advance online publication, June 28, 2013; 10.1038/jid.2013.292

Dominant Th1 and Minimal Th17 Skewing in Discoid Lupus Revealed by Transcriptomic Comparison with Psoriasis

Ali Jabbari, Mayte Suárez-Fariñas, Judilyn Fuentes-Duculan, Juana Gonzalez, Inna Cueto, Andrew G Franks, Jr and James G Krueger

J Invest Dermatol 2014 134: 87-95; advance online publication, June 14, 2013; 10.1038/jid.2013.269

Nonpathogenic Bacteria Alleviating Atopic Dermatitis Inflammation Induce IL-10-Producing Dendritic Cells and Regulatory Tr1 Cells

Thomas Volz, Yuliya Skabytska, Emmanuella Guenova, Ko-Ming Chen, Julia-Stefanie Frick, Carsten J Kirschning, Susanne Kaesler, Martin Röcken and Tilo Biedermann

J Invest Dermatol 2014 134: 96-104; advance online publication, June 28, 2013; 10.1038/jid.2013.291

KERATINOCYTES/EPIDERMIS

Reduced Inflammatory Threshold Indicates Skin Barrier Defect in Transglutaminase 3 Knockout Mice

Peter Bognar, Ilona Nemeth, Balazs Mayer, Dora Haluszka, Norbert Wikonkal, Eszter Ostorhazi, Susan John, Mats Paulsson, Neil Smyth, Maria Pasztoi, Edit I Buzas, Robert Szipocs, Attila Kolonics, Erzsebet Temesvari and Sarolta Karpati

J Invest Dermatol 2014 134: 105-111; advance online publication, July 24, 2013; 10.1038/jid.2013.307

Plakophilin 2 Affects Cell Migration by Modulating Focal Adhesion Dynamics and Integrin Protein Expression

Jennifer L Koetsier, Evangeline V Amargo, Viktor Todorović, Kathleen J Green and Lisa M Godsel

J Invest Dermatol 2014 134: 112-122; advance online publication, June 13, 2013; 10.1038/jid.2013.266

MELANOCYTES/MELANOMA

Pro-Invasive Activity of the Hippo Pathway Effectors YAP and TAZ in Cutaneous Melanoma^JIDOPEN

Flore Nallet-Staub, Véronique Marsaud, Ling Li, Cristèle Gilbert, Sophie Dodier, Véronique Bataille, Marius Sudol, Meenhard Herlyn and Alain Mauviel

J Invest Dermatol 2014 134: 123-132; advance online publication, July 29, 2013; 10.1038/jid.2013.319

A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo^JIDOPEN

James A Lister, Amy Capper, Zhiqiang Zeng, Marie E Mathers, Jennifer Richardson, Karthika Paranthaman, Ian J Jackson and E Elizabeth Patton

J Invest Dermatol 2014 134: 133-140; advance online publication, July 5, 2013; 10.1038/jid.2013.293

Phenotypic Characterization of Nevus and Tumor Patterns in MITF E318K Mutation Carrier Melanoma Patients

Richard A Sturm, Carly Fox, Phil McClenahan, Kasturee Jagirdar, Maider Ibarrola-Villava, Parastoo Banan, Nicola C Abbott, Gloria Ribas, Brian Gabrielli, David L Duffy and H Peter Soyer

J Invest Dermatol 2014 134: 141-149; advance online publication, June 17, 2013; 10.1038/jid.2013.272

Defective Decatenation Checkpoint Function Is a Common Feature of Melanoma

Kelly Brooks, Kee Ming Chia, Loredana Spoerri, Pamela Mukhopadhyay, Matthew Wigan, Mitchell Stark, Sandra Pavey and Brian Gabrielli

J Invest Dermatol 2014 134: 150-158; advance online publication, June 13, 2013; 10.1038/jid.2013.264

A Signal Transduction Pathway from TGF-β1 to SKP2 via Akt1 and c-Myc and its Correlation with Progression in Human Melanoma

Xuan Qu, Liangliang Shen, Yan Zheng, Yang Cui, Zhihui Feng, Feng Liu and Jiankang Liu

J Invest Dermatol 2014 134: 159-167; advance online publication, June 21, 2013; 10.1038/jid.2013.281

Inhibition of the Prohormone Convertase Subtilisin-Kexin Isoenzyme-1 Induces Apoptosis in Human Melanoma Cells

Nina Weiß, Agatha Stegemann, Marwa A T Elsayed, Karin U Schallreuter, Thomas A Luger, Karin Loser, Dieter Metze, Carsten Weishaupt and Markus Böhm

J Invest Dermatol 2014 134: 168-175; advance online publication, June 27, 2013; 10.1038/jid.2013.282

Increased Levels of Circulating Microparticles Are Associated with Increased Procoagulant Activity in Patients with Cutaneous Malignant Melanoma

Claire Laresche, Fabien Pelletier, Francine Garnache-Ottou, Thomas Lihoreau, Sabeha Biichlé, Guillaume Mourey, Philippe Saas, Philippe Humbert, Estelle Seilles and François Aubin

J Invest Dermatol 2014 134: 176-182; advance online publication, June 28, 2013; 10.1038/jid.2013.288

Oxidative Stress–Induced Calreticulin Expression and Translocation: New Insights into the Destruction of Melanocytes

Yajun Zhang, Ling Liu, Liang Jin, Xiuli Yi, Erle Dang, Yang Yang, Chunying Li and Tianwen Gao

J Invest Dermatol 2014 134: 183-191; advance online publication, June 14, 2013; 10.1038/jid.2013.268

PHOTOBIOLOGY

UVB-Induced Skin Inflammation and Cutaneous Tissue Injury Is Dependent on the MHC Class I–Like Protein, CD1d^JIDOPEN

Stephan Ryser, Marlène Schuppli, Beatrice Gauthier, Dianelys R Hernandez, Olivier Roye, Daniel Hohl, Bruce German, James A Holzwarth and Angus M Moodycliffe

J Invest Dermatol 2014 134: 192-202; advance online publication, July 18, 2013; 10.1038/jid.2013.300

TUMOR BIOLOGY

RhoB Promotes Cancer Initiation by Protecting Keratinocytes from UVB-Induced Apoptosis but Limits Tumor Aggressiveness

Nicolas Meyer, Alexis Peyret-Lacombe, Bruno Canguilhem, Claire Médale-Giamarchi, Kenza Mamouni, Agnese Cristini, Sylvie Monferran, Laurence Lamant, Thomas Filleron, Anne Pradines, Olivier Sordet and Gilles Favre

J Invest Dermatol 2014 134: 203-212; advance online publication, June 21, 2013; 10.1038/jid.2013.278

Mutational Landscape of Basal Cell Carcinomas by Whole-Exome Sequencing

Shyam S Jayaraman, David J Rayhan, Salar Hazany and Michael S Kolodney

J Invest Dermatol 2014 134: 213-220; advance online publication, June 17, 2013; 10.1038/jid.2013.276

Reduced Susceptibility to Two-Stage Skin Carcinogenesis in Mice with Epidermis-Specific Deletion of Cd151

Norman Sachs, Pablo Secades, Laura van Hulst, Ji-Ying Song and Arnoud Sonnenberg

J Invest Dermatol 2014 134: 221-228; advance online publication, June 21, 2013; 10.1038/jid.2013.280

CD164 and FCRL3 Are Highly Expressed on CD4+CD26− T Cells in Sézary Syndrome Patients

Maria Wysocka, Andrew V Kossenkov, Bernice M Benoit, Andrea B Troxel, Elisha Singer, Andras Schaffer, Brian Kim, Tzvete Dentchev, Satoshi Nagata, Tomoko Ise, Louise C Showe and Alain H Rook

J Invest Dermatol 2014 134: 229-236; advance online publication, June 21, 2013; 10.1038/jid.2013.279

WOUND HEALING

Hyperbaric Oxygen Reduces Matrix Metalloproteinases in Ischemic Wounds through a Redox-Dependent Mechanism

Qixu Zhang and Lisa J Gould

J Invest Dermatol 2014 134: 237-246; advance online publication, July 18, 2013; 10.1038/jid.2013.301

Impaired Wound Repair in Adult Endoglin Heterozygous Mice Associated with Lower NO Bioavailability

Eduardo Pérez-Gómez, Mirjana Jerkic, Marta Prieto, Gaelle del Castillo, Ester Martín-Villar, Michelle Letarte, Carmelo Bernabeu, Fernando Pérez-Barriocanal, Miguel Quintanilla and José M López-Novoa

J Invest Dermatol 2014 134: 247-255; advance online publication, June 13, 2013; 10.1038/jid.2013.263

Dermatopontin Regulates Fibrin Formation and Its Biological Activity

Weimin Wu, Osamu Okamoto, Aiko Kato, Noritaka Matsuo, Motoyoshi Nomizu, Hidekatsu Yoshioka and Sakuhei Fujiwara

J Invest Dermatol 2014 134: 256-263; advance online publication, July 22, 2013; 10.1038/jid.2013.305

Letters to the Editor

Lack of Response to Laser Comb in Spontaneous and Graft-Induced Alopecia Areata in C3H/HeJ Mice

Lloyd E King, Jr, Kathleen A Silva, Victoria E Kennedy and John P Sundberg

J Invest Dermatol 2014 134: 264-266; advance online publication, June 10, 2013; 10.1038/jid.2013.252

Dichotomization of Primary Outcomes Serves External Validity

Alain Dupuy and Dany Nassar

J Invest Dermatol 2014 134: 267; advance online publication, June 11, 2013; 10.1038/jid.2013.258

Binary Outcomes Are Not Better than Continuous Variables in Randomized Controlled Trials

Jan Kottner and David L Streiner

J Invest Dermatol 2014 134: 267-268; advance online publication, June 11, 2013; 10.1038/jid.2013.256

Treatment-Related Restoration of Langerhans Cell Migration in Psoriasis^JIDOPEN

Frances L Shaw, Kieran T Mellody, Stephanie Ogden, Rebecca J Dearman, Ian Kimber and Christopher E M Griffiths

J Invest Dermatol 2014 134: 268-271; advance online publication, June 28, 2013; 10.1038/jid.2013.289

Loss of IL36RN Function Does Not Confer Susceptibility to Psoriasis Vulgaris

Dorottya M Berki, Satveer K Mahil, A David Burden, Richard C Trembath, Catherine H Smith, Francesca Capon and Jonathan N Barker

J Invest Dermatol 2014 134: 271-273; advance online publication, June 21, 2013; 10.1038/jid.2013.285

Plectin Mutations Underlie Epidermolysis Bullosa Simplex in 8% of Patients

Marieke C Bolling, Jan D H Jongbloed, Ludolf G Boven, Gilles F H Diercks, Frances J D Smith, W H Irwin McLean and Marcel F Jonkman

J Invest Dermatol 2014 134: 273-276; advance online publication, June 17, 2013; 10.1038/jid.2013.277

Decreased Expression of Acetylcholine Esterase in Cholinergic Urticaria with Hypohidrosis or Anhidrosis

Yu Sawada, Motonobu Nakamura, Toshinori Bito, Jun-Ichi Sakabe, Rieko Kabashima-Kubo, Ryosuke Hino, Miwa Kobayashi and Yoshiki Tokura

J Invest Dermatol 2014 134: 276-279; advance online publication, June 7, 2013; 10.1038/jid.2013.244

Mouse Alopecia Areata and Heart Disease: Know Your Mouse!

John P Sundberg, Lucie Chevallier, Kathleen A Silva, Victoria E Kennedy, Beth A Sundberg, Qiaoli Li, Jouni Uitto, Lloyd E King, Jr and Annerose Berndt

J Invest Dermatol 2014 134: 279-281; advance online publication, June 17, 2013; 10.1038/jid.2013.273

Aedes aegypti Saliva Contains a Prominent 34-kDa Protein that Strongly Enhances Dengue Virus Replication in Human Keratinocytes

Pornapat Surasombatpattana, Peeraya Ekchariyawat, Rodolphe Hamel, Sirilaksana Patramool, Supatra Thongrungkiat, Mélanie Denizot, Pascal Delaunay, Frédéric Thomas, Natthanej Luplertlop, Hans Yssel and Dorothée Missé

J Invest Dermatol 2014 134: 281-284; advance online publication, June 10, 2013; 10.1038/jid.2013.251

Mutation in AQP5, Encoding Aquaporin 5, Causes Palmoplantar Keratoderma Bothnia Type

Xu Cao, Jinghua Yin, Huijun Wang, Jiahui Zhao, Jie Zhang, Lanlan Dai, Jianguo Zhang, Hui Jiang, Zhimiao Lin and Yong Yang

J Invest Dermatol 2014 134: 284-287; advance online publication, July 18, 2013; 10.1038/jid.2013.302

Somatic BRAF and NRAS Mutations in Familial Melanomas with Known Germline CDKN2A Status: A GenoMEL Study

Abdlsattar Zebary, Katarina Omholt, Remco van Doorn, Paola Ghiorzo, Katja Harbst, Carolina Hertzman Johansson, Veronica Höiom, Göran Jönsson, Dace Pjanova, Susana Puig, Giovanna B Scarra, Mark Harland, Håkan Olsson, Suzanne Egyhazi Brage, Jane Palmer, Lena Kanter-Lewensohn, Ismini Vassilaki, Nicholas K Hayward, Julia Newton-Bishop, Nelleke A Gruis and Johan Hansson the Melanoma Genetics Consortium (GenoMEL)

J Invest Dermatol 2014 134: 287-290; advance online publication, June 14, 2013; 10.1038/jid.2013.270

Nuclear Factor-κB Pathway–Activating Gene Aberrancies in Primary Cutaneous Large B-Cell Lymphoma, Leg Type

Lianne Koens, Willem H Zoutman, Passorn Ngarmlertsirichai, Grzegorz K Przybylski, Piotr Grabarczyk, Maarten H Vermeer, Rein Willemze, Patty M Jansen, Christian A Schmidt and Cornelis P Tensen

J Invest Dermatol 2014 134: 290-292; advance online publication, June 13, 2013; 10.1038/jid.2013.265