Nature Reviews Neuroscience contents December 2013 Volume 14 Number 12 pp 815-877

TABLE OF CONTENTS
December 2013 Volume 14 Number 12
Impact Factor 31.673 *	In this issue Research Highlights Reviews Perspectives Correspondence Also this month Article series: Neuroscience and the law  Featured article: AMPA-silent synapses in brain development and pathology Eric Hanse, Henrik Seth & Ilse Riebe
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Nature Methods  COLLECTION ON LIGHT-SHEET MICROSCOPY  The use of a planar sheet of light for illumination in light-sheet fluorescence microscopy allows researchers to image sample volumes faster than is possible with other current methods, while limiting light dosage. A collection of articles from Nature Methods, Nature Communications and Nature Reviews Molecular Cell Biology provides a brief overview of this exciting imaging technology and the biological research applications that it makes possible. Produced with support from:  Carl Zeiss Microscopy
RESEARCH HIGHLIGHTS Top Dendrites: Dendritic processors p815 | doi:10.1038/nrn3644 Active dendritic processing has a role in neuronal computations in the visual system. PDF Neurological disorders: Eaten alive! p816 | doi:10.1038/nrn3630 By engulfing viable neurons, microglia can contribute to the brain atrophy that results from transient ischaemia. PDF Sleep: Sleep: not such a waste p816 | doi:10.1038/nrn3632 A study in mice suggests that an important function of sleep may be the removal of waste products from the brain. PDF Cerebral cortex: Sizing up the columns p817 | doi:10.1038/nrn3631 A new study shows that the number of neurons in cortical barrel columns varies markedly within individual rats. PDF Neural development: Tracing interneuron roots p818 | doi:10.1038/nrn3628 The results of two new studies suggest that human cortical interneurons predominantly originate in subcortical regions. PDF Cell fate: The patterns of fate p818 | doi:10.1038/nrn3643 Neural progenitor cell (NPC) profileration in mice is associated with oscillating patterns of expression of several transcription factors, whereas NPC differentiation is associated with the sustained, dominant expression of particular transcription factors. PDF Pain: A wandering brain reduces pain? p819 | doi:10.1038/nrn3639 A new study suggests that sustained activity in the default-mode network during a painful stimulus influences activity in pain-reducing brain areas. PDF Synaptic transmission: Releasing the brakes p820 | doi:10.1038/nrn3629 Two recent studies show that vasoactive intestinal polypeptide-expressing interneurons exert a disinhibitory effect on cortical pyramidal cells in a number of brain areas, and this has important implications for control of cortical processing and behaviour. PDF Synaptic plasticity: Balancing firing rates in vivo p820 | doi:10.1038/nrn3637 Two studies provide a first account of homeostatic plasticity of firing rate in the cortex of awake animals. PDF IN BRIEF Psychiatric disorders: Creating ripples | Cellular neuroscience: Prion prevention | Behaviour: To eat or not to eat? | Cellular neuroscience: Merging membranes | Neurodegeneration: Search and rescue | Neurogenetics: Expression restrictions | Neuroimaging: More precise MRI PDF Neuroscience JOBS of the week Neuroscience Research Faculty Positions Hussman Institute for Autism Behavioral Neuroscience Postdoctoral Position University of Guelph, Department of Psychology Assistant or Associate Professor of Neuroscience University of Virginia Assistant Professor of Neuroscience University of Arizona Tenure-Track Faculty Position - University Lecturer University of Cambridge More Science jobs from Neuroscience EVENT 16th International Neuroscience Winter Conference 12.04.14 Sölden, Austria More science events from
REVIEWS		Top
Temporal fate specification and neural progenitor competence during development Minoree Kohwi & Chris Q. Doe p823 | doi:10.1038/nrn3618 During development, individual neural progenitors give rise to a series of distinct types of neural progeny that are produced in a specific temporal order. Kohwi and Doe discuss how temporal neural patterning is dictated by extrinsic and intrinsic cues known as temporal-identity factors, as well as by changes in progenitor competence in response to these factors. Abstract | Full Text | PDF
AMPA-silent synapses in brain development and pathology Eric Hanse, Henrik Seth & Ilse Riebe p839 | doi:10.1038/nrn3642 Newly generated glutamatergic synapses lack functional AMPA receptor-mediated transmission. Depending on the type of activity that these newborn AMPA-silent synapses are exposed to, they are eventually either eliminated or stabilized. Hanse et al. review recent studies on the abnormal generation of AMPA-silent synapses and on premature or delayed unsilencing that highlight their role in brain pathology. Abstract | Full Text | PDF | Supplementary information
Hepatic encephalopathy: effects of liver failure on brain function Vicente Felipo p851 | doi:10.1038/nrn3587 Increasing evidence of the high incidence of mild cognitive impairment and psychomotor slowing in patients with chronic liver disease has highlighted the need to treat the neurological alterations of these patients. In this article, Felipo reviews the latest studies aimed at understanding how liver failure affects brain function and potential ways to ameliorate these effects. Abstract | Full Text | PDF
PERSPECTIVES		Top
SCIENCE AND SOCIETY The neural basis of humour processing Pascal Vrticka, Jessica M. Black & Allan L. Reiss p860 | doi:10.1038/nrn3566 In this Perspective article, Reiss and colleagues summarize the most recent neuroimaging studies attempting to determine the neural correlates of humour and discuss the influence of sex, personality traits and certain psychiatric disorders on humour appreciation. Abstract | Full Text | PDF
SCIENCE AND SOCIETY Article series: Neuroscience and the law Memory development: implications for adults recalling childhood experiences in the courtroom Mark L. Howe p869 | doi:10.1038/nrn3627 Cognitive and neurobiological changes during development influence the content and longevity of memories for events that occurred in early childhood. Mark L. Howe discusses the implications for court cases in which the main evidence consists of adults' recollections of childhood experiences. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: A test is not a test Christian Hoppe p877 | doi:10.1038/nrn3475-c5 Full Text | PDF
REPLY		Top
Reply: Empirical evidence for low reproducibility indicates low pre-study odds Katherine S. Button, John P. A. Ioannidis, Claire Mokrysz, Brian A. Nosek, Jonathan Flint, Emma S. J. Robinson & Marcus R. Munafò p877 | doi:10.1038/nrn3475-c6 Full Text | PDF
CORRESPONDENCE		Top
Correspondence: Controlled substances and innovation of biomedicine: a preclinical perspective Adam Michael Stewart & Allan V. Kalueff p877 | doi:10.1038/nrn3530-c1 Full Text | PDF | Supplementary information
REPLY		Top
Reply: New victims of current drug laws David J. Nutt, Leslie A. King & David E. Nichols p877 | doi:10.1038/nrn3530-c2 Full Text | PDF
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2012 Journal Citation Report (Thomson Reuters, 2013)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.