Nature Communications - 20 November 2013

Advertisement Professor Martin Klotz talks to us about what excites him about Microbiology, why he joined Frontiers in Microbiology as our Field Chief Editor, and where he sees the field going. Read our interview with Professor Klotz     Weekly Content Alert 20 November 2013  Featured image: Peel et al. report on the viral transmission dynamics of a continent-wide population of African fruit bats. Latest content: Articles Corrigendum Journal homepage Recommend to library Web feed   Advertisement nature.com webcasts Macmillan Science Communication presents a custom webcast and live Q & A: Drug-induced liver injury: Genomic approaches to improve risk management Thursday December 5 There are two live sessions targeted at different time zones that you can join:  Europe and the Middle East: London 2pm GMT / Dubai 6pm GST   USA: San Francisco 10am PST / New York 1pm EST   Sponsored by:           Latest Articles View all Articles     Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A OPEN Lily M. Du, Paquita Nurden, Alan T. Nurden, Timothy C. Nichols, Dwight A. Bellinger, Eric S. Jensen, Sandra L. Haberichter, Elizabeth Merricks, Robin A. Raymer, Juan Fang, Sevasti B. Koukouritaki, Paula M. Jacobi, Troy B. Hawkins, Kenneth Cornetta, Qizhen Shi and David A. Wilcox Haemophilia is a genetic bleeding disorder associated with a deficiency in the coagulation factor VIII. Here, the authors use gene therapy to achieve stable overexpression of factor VIII in platelets of dogs with haemophilia A, preventing the occurrence of severe bleeding episodes for over 2.5 years. 19 November 2013 | doi: 10.1038/ncomms3773 Biological Sciences  Genetics  Medical research  Continent-wide panmixia of an African fruit bat facilitates transmission of potentially zoonotic viruses Alison J. Peel, David R. Sargan, Kate S. Baker, David T. S. Hayman, Jennifer A. Barr, Gary Crameri, Richard Suu-Ire, Christopher C. Broder, Tiziana Lembo, Lin-Fa Wang, Anthony R. Fooks, Stephen J. Rossiter, James L. N. Wood and Andrew A. Cunningham The African straw-coloured fruit bat lives in close proximity to humans and acts as reservoir for Lagos bat virus and henipaviruses. Here, the authors assess viral transmission dynamics in this species and its implications for public health using genetic and serological data. 19 November 2013 | doi: 10.1038/ncomms3770 Biological Sciences  Ecology  Evolution  Virology  Zoology  A nanoscale shape memory oxide Jinxing Zhang, Xiaoxing Ke, Gaoyang Gou, Jan Seidel, Bin Xiang, Pu Yu, Wen-I. Liang, Andrew M. Minor, Ying-hao Chu, Gustaaf Van Tendeloo, Xiaobing Ren and Ramamoorthy Ramesh Shape-memory materials hold great potential for actuators and aims to improve them focus on increasing the maximum strain that they exhibit in response to a stimulus. Here, the authors demonstrate a large shape-memory effect in bismuth ferrite, observing a maximum strain of up to 14%. 19 November 2013 | doi: 10.1038/ncomms3768 Physical Sciences  Applied physics  Nanotechnology  Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder OPEN Todd Lencz, Saurav Guha, Chunyu Liu, Jeffrey Rosenfeld, Semanti Mukherjee, Pamela DeRosse, Majnu John, Lijun Cheng, Chunling Zhang, Judith A. Badner, Masashi Ikeda, Nakao Iwata, Sven Cichon, Marcella Rietschel, Markus M. Nöthen, A.T.A. Cheng, Colin Hodgkinson, Qiaoping Yuan, John M. Kane, Annette T. Lee et al. Schizophrenia and bipolar disorder are important psychiatric disorders with overlapping genetic components. Here, the authors identify and replicate a genome-wide significant risk locus for the two disorders, and suggest a role for NDST3 in severe psychiatric disease. 19 November 2013 | doi: 10.1038/ncomms3739 Biological Sciences  Genetics  Discovery of the action of a geophysical synchrotron in the Earth's Van Allen radiation belts Ian R. Mann, E. A. Lee, S. G. Claudepierre, J. F. Fennell, A. Degeling, I. J. Rae, D. N. Baker, G. D. Reeves, H. E. Spence, L. G. Ozeke, R. Rankin, D. K. Milling, A. Kale, R. H. W. Friedel and F. Honary The processes influencing the Van Allen belt – a layer of charged particles inside the Earth's magnetosphere – are poorly understood. Using CRRES and NASA's Van Allen Probes data, Mann et al. suggest that ultra-low frequency waves may play a larger role in accelerating particles than previously thought. 19 November 2013 | doi: 10.1038/ncomms3795 Physical Sciences  Astronomy  Fluids and plasma physics  Planetary sciences  Electrically driven nanobeam laser OPEN Kwang-Yong Jeong, You-Shin No, Yongsop Hwang, Ki Soo Kim, Min-Kyo Seo, Hong-Gyu Park and Yong-Hee Lee Lasers for on-chip optical technologies should be as small as possible. Here, Jeong et al. achieve room-temperature lasing in an electrically driven nanobeam photonic structure using only 11 holes to confine the light. 19 November 2013 | doi: 10.1038/ncomms3822 Physical Sciences  Nanotechnology  Optical physics  Measurement of the intrinsic strength of crystalline and polycrystalline graphene Haider I. Rasool, Colin Ophus, William S. Klug, A. Zettl and James K. Gimzewski The two-dimensional structure of graphene is known to impart high strength, but can be hard to synthesize without grain boundaries. Here, the authors find that strength increases with grain boundary mismatch, which results from low atomic-scale strain in the carbon–carbon bonds at the boundary. 19 November 2013 | doi: 10.1038/ncomms3811 Physical Sciences  Materials science  Nanotechnology  In-gap quasiparticle excitations induced by non-magnetic Cu impurities in Na(Fe0.96Co0.03Cu0.01)As revealed by scanning tunnelling spectroscopy OPEN Huan Yang, Zhenyu Wang, Delong Fang, Qiang Deng, Qiang-Hua Wang, Yuan-Yuan Xiang, Yang Yang and Hai-Hu Wen In superconductors with sign-preserving pairing symmetries, Cooper pairs break when they scatter off magnetic impurities but not non-magnetic impurities. An observation of pair breaking by copper impurities in Na(Fe0.96Co0.03Cu0.01)As demonstrates that its pairing symmetry is sign-reversed. 19 November 2013 | doi: 10.1038/ncomms3749 Physical Sciences  Condensed matter  Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue Lan Wei-LaPierre, Ellie M. Carrell, Simona Boncompagni, Feliciano Protasi and Robert T. Dirksen The calcium-selective Orai1 channel regulates cytosolic calcium levels in a variety of cells. Here, the authors use transgenic mice with muscle-specific expression of dysfunctional Orai1 to show that Orai1-mediated store-operated calcium entry promotes growth and limits fatigue of adult skeletal muscle. 18 November 2013 | doi: 10.1038/ncomms3805 Biological Sciences  Cell biology  Medical research  All-optical control and visualization of ultrafast two-dimensional atomic motions in a single crystal of bismuth OPEN H. Katsuki, J.C. Delagnes, K. Hosaka, K. Ishioka, H. Chiba, E.S. Zijlstra, M.E. Garcia, H. Takahashi, K. Watanabe, M. Kitajima, Y. Matsumoto, K.G. Nakamura and K. Ohmori Controlling the motion of atoms in solids with light allows for a deeper understanding of their fundamental properties, yet most studies only deal with one spatial dimension. Katsuki et al. extend this approach to two-dimensional control and use it to visualize atomic motion in bismuth. 18 November 2013 | doi: 10.1038/ncomms3801 Physical Sciences  Condensed matter  Optical physics  Autophagy proteins regulate ERK phosphorylation OPEN Nuria Martinez-Lopez, Diana Athonvarangkul, Priti Mishall, Srabani Sahu and Rajat Singh The spatial organisation of mitogen-activated protein kinase (MAPK) signalling by scaffold proteins is an important determinant of signalling specificity. Martinez-Lopez et al. show that pre-autophagosomal structures can also act as scaffolds, recruiting the MAPK ERK1/2 and regulating its phosphorylation. 18 November 2013 | doi: 10.1038/ncomms3799 Biological Sciences  Cell biology  Natural variation in PTB1 regulates rice seed setting rate by controlling pollen tube growth Shuangcheng Li, Wenbo Li, Bin Huang, Xuemei Cao, Xingyu Zhou, Shumei Ye, Chengbo Li, Fengyan Gao, Ting Zou, Kailong Xie, Yun Ren, Peng Ai, Yangfan Tang, Xuemei Li, Qiming Deng, Shiquan Wang, Aiping Zheng, Jun Zhu, Huainian Liu, Lingxia Wang et al. Understanding the genetic factors that regulate panicle architecture is important for improving rice yields. In this study, Li et al. demonstrate that the gene PTB1 is critical for regulating panicle seed setting rate and pollen tube growth. 18 November 2013 | doi: 10.1038/ncomms3793 Biological Sciences  Plant sciences  Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy Hagai Abeliovich, Mostafa Zarei, Kristoffer T. G. Rigbolt, Richard J. Youle and Joern Dengjel The extent to which damaged and undamaged structures can be segregated within the mitochondrial network during mitophagy is unclear. Abeliovich et al. show that mitochondrial matrix proteins undergo mitophagic degradation at different rates, and that this depends on regulators of mitochondrial dynamics. 18 November 2013 | doi: 10.1038/ncomms3789 Biological Sciences  Cell biology  MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination Mengcheng Luo, Fang Yang, N. Adrian Leu, Jessica Landaiche, Mary Ann Handel, Ricardo Benavente, Sophie La Salle and P. Jeremy Wang Meiotic recombination enables reciprocal exchange of genetic material between paternal and maternal homologous chromosomes. Here, Luo et al. show that MEIOB, a novel meiosis-specific factor identified in a proteomics screen, forms complexes with RPA2 and SPATA22, and is required for meiotic recombination. 18 November 2013 | doi: 10.1038/ncomms3788 Biological Sciences  Cell biology  Molecular biology  Frequency-resolved optical gating capable of carrier-envelope phase determination Yutaka Nomura, Hideto Shirai and Takao Fuji The time-resolved characterization of laser pulses is important in particular for the development of optical characterization techniques at ultrashort timescales. Here, the authors develop a scheme that is able to characterize the electric-field evolution of femtosecond laser pulses. 15 November 2013 | doi: 10.1038/ncomms3820 Physical Sciences  Optical physics  Arabidopsis SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity OPEN Stefano Pietra, Anna Gustavsson, Christian Kiefer, Lothar Kalmbach, Per Hörstedt, Yoshihisa Ikeda, Anna N. Stepanova, Jose M. Alonso and Markus Grebe Cell and planar polarity are important for the organization of cells within organisms. Pietra et al. demonstrate in Arabidopsis that the SABRE protein is important for mediating cell and planar polarity by stabilizing the orientation of microtubules during cell division and cell elongation. 15 November 2013 | doi: 10.1038/ncomms3779 Biological Sciences  Cell biology  Plant sciences  Giant infrared absorption bands of electrons and holes in conjugated molecules Matibur Zamadar, Sadayuki Asaoka, David C. Grills and John R. Miller The absorption of mid-infrared light by organic molecules is used for diagnostics and sensing purposes. Here, Zamadar et al. find that mid-infrared molar absorption coefficients of conjugated molecules bearing charges, owing to polaron vibrations, are often more than one hundred times larger than those of comparable neutral molecules. 15 November 2013 | doi: 10.1038/ncomms3818 Physical Sciences  Materials science  Organic chemistry  The N-terminal domains of spider silk proteins assemble ultrafast and protected from charge screening Simone Schwarze, Fabian U. Zwettler, Christopher M. Johnson and Hannes Neuweiler Web spiders synthesize silk fibres at high speed, assisted by a self-associating protein domain, but the molecular details are not yet understood. Here, the authors use an engineered fluorescence probe in combination with mutagenesis to reveal the underlying kinetics and side chain contributions. 15 November 2013 | doi: 10.1038/ncomms3815 Chemical Sciences  Chemical biology  Organic chemistry  Three-dimensional optical holography using a plasmonic metasurface OPEN Lingling Huang, Xianzhong Chen, Holger Mühlenbernd, Hao Zhang, Shumei Chen, Benfeng Bai, Qiaofeng Tan, Guofan Jin, Kok-Wai Cheah, Cheng-Wei Qiu, Jensen Li, Thomas Zentgraf and Shuang Zhang Holographic techniques allow for the construction of 3D images by controlling the wave front of light beams. Huang et al. develop ultrathin plasmonic metasurfaces to provide 3D optical holographic image reconstruction in the visible and near-infrared regions for circularly polarized light. 15 November 2013 | doi: 10.1038/ncomms3808 Physical Sciences  Applied physics  Nanotechnology  Optical physics  Metasurface holograms for visible light Xingjie Ni, Alexander V. Kildishev and Vladimir M. Shalaev Holographic techniques provide phase and amplitude information for images of objects, but normally the hologram thickness is comparable to the light wavelength used. Ni et al. present ultra-thin plasmonic holograms that control amplitude and phase in the visible region and are just 30 nm thick. 15 November 2013 | doi: 10.1038/ncomms3807 Physical Sciences  Applied physics  Nanotechnology  Optical physics  Solid-source growth and atomic-scale characterization of graphene on Ag(111) Brian Kiraly, Erin V. Iski, Andrew J. Mannix, Brandon L. Fisher, Mark C. Hersam and Nathan P. Guisinger The integration of graphene with silver offers the promise of combining the electronic and plasmonic properties of both materials. Here, Kiraly et al. achieve the growth of graphene on a silver substrate, with the graphene electronic structure only minimally affected by the silver. 15 November 2013 | doi: 10.1038/ncomms3804 Physical Sciences  Materials science  Nanotechnology  Optical physics  Superconductivity at the border of electron localization and itinerancy Rong Yu, Pallab Goswami, Qimiao Si, Predrag Nikolic and Jian-Xin Zhu Iron pnictide and iron chalcogenide superconductors exhibit similar transition temperatures but markedly different electronic structure. Yu et al. suggest that this could be due to pairing being the strongest in the vicinity of a transition between localization and itineracy in both systems. 15 November 2013 | doi: 10.1038/ncomms3783 Physical Sciences  Condensed matter  Automatic protein structure solution from weak X-ray data OPEN Pavol Skubák and Navraj S. Pannu X-ray crystallography is a routine technique used to solve protein structures, but is often limited by weak anomalous scattering signals and low-resolution data. Here, the authors develop a synergistic algorithm to significantly increase the success rate of structure solution when the signal is weak. 15 November 2013 | doi: 10.1038/ncomms3777 Chemical Sciences  Materials science  Organic chemistry  A nonspecific defensive compound evolves into a competition avoidance cue and a female sex pheromone OPEN Ingmar Weiss, Thomas Rössler, John Hofferberth, Michael Brummer, Joachim Ruther and Johannes Stökl Chemical communication can evolve from compounds used for other purposes, but experimental evidence is scarce. Here, Weiss et al. show a gradual evolution of a defensive compound into a competition avoidance mediator and a sex pheromone, which was accompanied by diversification of chemical messengers to obtain the required specificity. 15 November 2013 | doi: 10.1038/ncomms3767 Biological Sciences  Evolution  Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes Qing Wei, Qingwen Xu, Yuxia Zhang, Yujie Li, Qing Zhang, Zeng Hu, Peter C. Harris, Vicente E. Torres, Kun Ling and Jinghua Hu The primary cilium is a protected cellular niche; however, the mechanisms that control the entry of proteins into this environment are poorly understood. Wei et al. show that FBF1 is a component of transition fibres at the ciliary base, and is required for the entry of intraflagellar transport complexes. 15 November 2013 | doi: 10.1038/ncomms3750 Biological Sciences  Cell biology  Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes Taketoshi Kajimoto, Taro Okada, Satoshi Miya, Lifang Zhang and Shun-ichi Nakamura Exosomes originate from inward budding of the endosomal membrane followed by cargo sorting, and are released from the cell by fusion of the endosome with the plasma membrane. Kajimoto et al. show that the cargo sorting process depends on continuous local activation of endosomal sphingosine 1-phosphate receptors. 15 November 2013 | doi: 10.1038/ncomms3712 Biological Sciences  Cell biology  From protein sequence to dynamics and disorder with DynaMine Elisa Cilia, Rita Pancsa, Peter Tompa, Tom Lenaerts and Wim F. Vranken Predicting the dynamics and disorder of a protein is a computationally complex task that, until now, has depended on prior knowledge of protein structure. Cilia et al. develop a tool to rapidly predict protein backbone dynamics based on sequence alone. 14 November 2013 | doi: 10.1038/ncomms3741 Biological Sciences  Bioinformatics  Biophysics  Quality versus quantity of social ties in experimental cooperative networks OPEN Hirokazu Shirado, Feng Fu, James H. Fowler and Nicholas A. Christakis The effect of the rate of forming and breaking social ties on cooperative behaviour is not clear. Here, the authors experimentally test the effect of rewiring the connections between individuals, and find that optimal levels of cooperation are achieved at intermediate levels of change in ties. 14 November 2013 | doi: 10.1038/ncomms3814 Biological Sciences  Evolution  VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA Kristoffer S. Winther, Ditlev E. Brodersen, Alistair K. Brown and Kenn Gerdes Toxin–antitoxin systems have been implicated in the pathogenicity of Mycobacterium tuberculosis. Here, the authors study the function of the M. tuberculosis toxin VapC20 and show that it can impair protein translation and inhibit bacterial growth by cleaving the Sarcin–Ricin loop of 23S rRNA 14 November 2013 | doi: 10.1038/ncomms3796 Biological Sciences  Microbiology  Molecular biology  Netrin-dependent downregulation of Frazzled/DCC is required for the dissociation of the peripodial epithelium in Drosophila Rosemary Manhire-Heath, Sofia Golenkina, Robert Saint and Michael J. Murray During the eversion of Drosophila wing imaginal discs, epithelial cells become migratory in a process similar to the epithelial-to-mesenchymal transition. Here the authors show that the secreted chemoattractant NetrinA promotes epithelial breakdown during disc eversion via downregulation of its receptor Frazzled. 14 November 2013 | doi: 10.1038/ncomms3790 Biological Sciences  Developmental biology  Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin OPEN Matthias Zebisch, Yang Xu, Christos Krastev, Bryan T. MacDonald, Maorong Chen, Robert J. C. Gilbert, Xi He and E. Yvonne Jones R-spondins are secreted factors that potentiate Wnt signalling by inhibiting the degradation of Wnt receptors by transmembrane E3 ubiquitin ligases. Zebisch et al. present a panel of crystal structures that reveal how this inhibition occurs. 14 November 2013 | doi: 10.1038/ncomms3787 Biological Sciences  Cell biology  Doped organic transistors operating in the inversion and depletion regime OPEN Björn Lüssem, Max L. Tietze, Hans Kleemann, Christoph Hoßbach, Johann W. Bartha, Alexander Zakhidov and Karl Leo Inversion type transistors – which are widely used in silicon-based industries – are thought to not be obtainable in organic devices. Lüssem et al. realize the first inversion organic field-effect transistor by doping at the source and drain contacts without degrading its ON/OFF ratio. 14 November 2013 | doi: 10.1038/ncomms3775 Physical Sciences  Applied physics  Nanotechnology  Circadian rhythms in Mexican blind cavefish Astyanax mexicanus in the lab and in the field Andrew Beale, Christophe Guibal, T. Katherine Tamai, Linda Klotz, Sophie Cowen, Elodie Peyric, Víctor H. Reynoso, Yoshiyuki Yamamoto and David Whitmore Body clocks modulate physiological processes to follow a day–night cycle, but whether animals exposed to constant darkness express circadian rhythms is unknown. Here, the authors examine the expression of circadian genes in Mexican cavefish, and find that these resemble a pattern expected from exposure to constant daylight. 14 November 2013 | doi: 10.1038/ncomms3769 Biological Sciences  Evolution  Zoology  A Ca2+-dependent signalling circuit regulates influenza A virus internalization and infection Yoichiro Fujioka, Masumi Tsuda, Asuka Nanbo, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki and Yusuke Ohba Influenza virus can enter host cells through endocytosis, but the molecular pathways involved in this process are not fully understood. Here, the authors dissect these pathways and identify Ca2+ as a key regulator of influenza A virus entry via both clathrin-mediated and clathrin-independent endocytosis. 14 November 2013 | doi: 10.1038/ncomms3763 Biological Sciences  Cell biology  Virology  Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis Ida Annunziata, Annette Patterson, Danielle Helton, Huimin Hu, Simon Moshiach, Elida Gomero, Ralph Nixon and Alessandra d'Azzo The enzyme NEU1 negatively regulates lysosomal exocytosis in various cell types. Annunziata et al. show that mice deficient in NEU1 display Alzheimer's disease-like pathology and that direct brain administration of NEU1 reduces pathology in an Alzheimer's disease mouse model. 14 November 2013 | doi: 10.1038/ncomms3734 Biological Sciences  Medical research  Neuroscience  Spike timing-dependent selective strengthening of single climbing fibre inputs to Purkinje cells during cerebellar development OPEN Yoshinobu Kawamura, Hisako Nakayama, Kouichi Hashimoto, Kenji Sakimura, Kazuo Kitamura and Masanobu Kano Cerebellar development involves activity-dependent strengthening of synaptic contacts between climbing fibres and Purkinje cells. Kawamura et al. show that temporally clustered multiple climbing fibre inputs contribute to characteristic burst spiking in immature Purkinje cells before specific contacts are strengthened. 14 November 2013 | doi: 10.1038/ncomms3732 Biological Sciences  Neuroscience  Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization Yu-Zen Chen, James Mapes, Eui-Seung Lee, Riley Robert Skeen-Gaar and Ding Xue As they die, apoptotic cells present phosphatidylserine on the outer leaflet of the plasma membrane, which serves as an 'eat-me' signal for nearby phagocytes. Chen et al. identify the caspase substrate CED-8 as a key regulator of phosphatidylserine externalization during apoptosis in C. elegans. 14 November 2013 | doi: 10.1038/ncomms3726 Biological Sciences  Cell biology  Ballistic-like supercurrent in suspended graphene Josephson weak links Naomi Mizuno, Bent Nielsen and Xu Du Attempts to observe new phenomena in graphene–superconductor hybrid devices have been hindered by the poor quality of the junctions formed. Suspended graphene Josephson junctions that exhibit superlative transport characteristics fabricated by Mizuno et al. could be the solution to this problem. 14 November 2013 | doi: 10.1038/ncomms3716 Physical Sciences  Applied physics  Condensed matter  Nanotechnology  Room-temperature air-stable spin transport in bathocuproine-based spin valves Xiangnan Sun, Marco Gobbi, Amilcar Bedoya-Pinto, Oihana Txoperena, Federico Golmar, Roger Llopis, Andrey Chuvilin, Fèlix Casanova and Luis E Hueso Spin valves with organic semiconductors sandwiched between two ferromagnetic layers can have similar performance as their inorganic counterparts. Here, the authors fabricate bathocuproine spin valves with good air stability and show that the transport takes place through the organic layer. 13 November 2013 | doi: 10.1038/ncomms3794 Physical Sciences  Applied physics  Materials science  Janus cyclic peptide–polymer nanotubes Maarten Danial, Carmen My-Nhi Tran, Philip G. Young, Sébastien Perrier and Katrina A. Jolliffe Cyclic peptide–polymer nanotubes are promising functional materials. Here, the authors present asymmetric cyclic peptide–polymer conjugates that form nanotubes of controlled length with dual functionality via a mixing or demixing polymeric corona, the latter leading to Janus nanotubes. 13 November 2013 | doi: 10.1038/ncomms3780 Chemical Sciences  Materials science  Nanotechnology  Organic chemistry  Oxygen-driven anisotropic transport in ultra-thin manganite films OPEN Baomin Wang, Lu You, Peng Ren, Xinmao Yin, Yuan Peng, Bin Xia, Lan Wang, Xiaojiang Yu, Sock Mui Poh, Ping Yang, Guoliang Yuan, Lang Chen, Andrivo Rusydi and Junling Wang Transition metal oxides can have exotic electronic phases because of the interplay of charge, spin and orbital degrees of freedom. Here, the authors investigate thin films of La0.7Sr0.3MnO3 and show a new phase with transport anisotropy under large tensile strain. 13 November 2013 | doi: 10.1038/ncomms3778 Physical Sciences  Condensed matter  Materials science  Heat-shock protein dysregulation is associated with functional and pathological TDP-43 aggregation Hsiang-Yu Chang, Shin-Chen Hou, Tzong-Der Way, Chi-Huey Wong and I-Fan Wang Misfolding and aggregation of TAR DNA-binding protein 43 is implicated in various neurodegenerative diseases. Chang et al. show that aggregation of this protein is regulated by heat-shock proteins, which act to reduce the amount of pathological protein aggregates. 13 November 2013 | doi: 10.1038/ncomms3757 Biological Sciences  Cell biology  Neuroscience  A common variant at 8q24.21 is associated with renal cell cancer Julius Gudmundsson, Patrick Sulem, Daniel F. Gudbjartsson, Gisli Masson, Vigdis Petursdottir, Sverrir Hardarson, Sigurjon A. Gudjonsson, Hrefna Johannsdottir, Hafdis Th. Helgadottir, Simon N. Stacey, Olafur Th. Magnusson, Hannes Helgason, Angeles Panadero, Loes F. van der Zanden, Katja K. H. Aben, Sita H. Vermeulen, Egbert Oosterwijk, Augustine Kong, Jose I. Mayordomo, Asgerdur Sverrisdottir et al. Renal cell carcinoma (RCC) accounts for 80–90% of all kidney cancers, but to date, only five genome-wide significant RCC risk loci have been identified. Here, Gudmundsson et al. identify a new RCC susceptibility locus and provide insight into the genetic basis of the disease. 13 November 2013 | doi: 10.1038/ncomms3776 Biological Sciences  Cancer  Genetics  Biologically enhanced cathode design for improved capacity and cycle life for lithium-oxygen batteries Dahyun Oh, Jifa Qi, Yi-Chun Lu, Yong Zhang, Yang Shao-Horn and Angela M. Belcher Lithium-oxygen batteries can deliver high-energy densities, but capacity, rate performance and cycle life are still critical issues. Oh et al. report biologically templated synthesis of manganese oxide nanowires, which exhibit excellent electrochemical performance and cost-efficiency. 13 November 2013 | doi: 10.1038/ncomms3756 Chemical Sciences  Biotechnology  Catalysis  Materials science  Conjugated organic framework with three-dimensionally ordered stable structure and delocalized π clouds OPEN Jia Guo, Yanhong Xu, Shangbin Jin, Long Chen, Toshihiko Kaji, Yoshihito Honsho, Matthew A. Addicoat, Jangbae Kim, Akinori Saeki, Hyotcherl Ihee, Shu Seki, Stephan Irle, Masahiro Hiramoto, Jia Gao and Donglin Jiang Covalent organic frameworks can utilize π-stacking interactions for the formation of ordered, layered frameworks. Here, the authors report an ordered framework with tailored π-interactions resulting in periodic ordering in three dimensions, which leads to enhanced stability and electronic properties. 13 November 2013 | doi: 10.1038/ncomms3736 Chemical Sciences  Materials science  Organic chemistry  Physical chemistry  Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif OPEN Mark P. Hamilton, Kimal Rajapakshe, Sean M. Hartig, Boris Reva, Michael D. McLellan, Cyriac Kandoth, Li Ding, Travis I. Zack, Preethi H. Gunaratne, David A. Wheeler, Cristian Coarfa and Sean E. McGuire AGO-CLIP permits the identification of miRNA target genes. Here, Hamilton et al. compile publicly available AGO-CLIP data and combine this information with miRNA analysis from The Cancer Genome Atlas, permitting the identification of an oncogenic miRNA superfamily that targets tumour suppressor genes. 13 November 2013 | doi: 10.1038/ncomms3730 Biological Sciences  Bioinformatics  Cancer  Predictive codes of familiarity and context during the perceptual learning of facial identities Matthew A. J. Apps and Manos Tsakiris Predictive coding by neural circuits is implicated in visual perception and recognition. Apps and Tsakiris show that contextual familiarity is processed by the superior temporal sulcus and that prediction errors that update facial familiarity are processed by the fusiform face area. 13 November 2013 | doi: 10.1038/ncomms3698 Biological Sciences  Neuroscience    Nature Communiactions JOBS of the week Postdoctoral Scholar University of California, San Francisco (UCSF) Research Assistant Medical Research Council PostDoctoral University of Geneva - Switzerland Research Fellow The University of Manchester Postdoctoral fellow in cancer biology University of Oslo Postdoctoral Research Fellows Max Planck Institute for Molecular Biomedicine Postdoctoral Fellow Icahn School of Medicine at Mount Sinai Research Associate Imperial College London Research Fellow Singapore Institute for Clinical Sciences postdoc research fellow University of Michigan More Science jobs from Nature Communiactions EVENT Clinical Virology Symposium 27.04.14 Florida, USA More science events from       Latest Corrigendum     Corrigendum: Ultrafast universal quantum control of a quantum-dot charge qubit using Landau–Zener–Stückelberg interference Gang Cao, Hai-Ou Li, Tao Tu, Li Wang, Cheng Zhou, Ming Xiao, Guang-Can Guo, Hong-Wen Jiang and Guo-Ping Guo 13 November 2013 | doi: 10.1038/ncomms3806 Physical Sciences  Applied physics  Condensed matter  Nanotechnology      Advertisement Choose Scientific Reports for fast, efficient, open access publishing  94% of authors said they are likely or very likely to recommend Scientific Reports to their colleagues* 91% of authors would publish in Scientific Reports again*  SUBMIT your paper today!  *Nature Publishing Group author survey, data correct as of September 2013   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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