Nature Reviews Molecular Cell Biology contents December 2013 Volume 14 Number 12 pp749-829

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TABLE OF CONTENTS
December 2013 Volume 14 Number 12
Impact Factor 37.162 *	In this issue Research Highlights Foreword Focus on: Organelle biogenesis and homeostasis Perspectives Also this month  Featured article: The biophysics and cell biology of lipid droplets Abdou Rachid Thiam, Robert V. Farese Jr & Tobias C. Walther
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RESEARCH HIGHLIGHTS Top Ageing: A little bit of stress does you good p749 | doi:10.1038/nrm3703 Mild mitochondrial stress prolongs longevity by inhibiting insulin signalling. PDF Cell division: Ciliary membrane inheritance directs ciliogenesis p750 | doi:10.1038/nrm3697 Asymmetric ciliary membrane inheritance leads to the asymmetric re-establishment of the cilium and ciliary signalling in daughter cells. PDF Calcium: 'Working out' mitochondrial calcium p750 | doi:10.1038/nrm3704 Mice lacking the mitochondrial calcium uniporter have an impaired ability for strenuous muscular work. PDF Nuclear organization: Microtubule shaping of the nucleus p752 | doi:10.1038/nrm3698 Nuclear shape is regulated by dppa2-mediated control of microtubule assembly. PDF Stem cells: A WNT switch to ageing p752 | doi:10.1038/nrm3701 HSC ageing in mice depends on a switch from canonical to non-canonical WNT signalling. PDF Cell adhesion: The 'ins' and 'outs' of integrin signalling p752 | doi:10.1038/nrm3708 Shows how talin and G[alpha]13 determine the direction of integrin signalling. PDF JOURNAL CLUB Stem cell renewal theory turns 60 p754 | doi:10.1038/nrm3706 The sixtieth anniversary of the 'stem cell renewal theory' by Yves Clermont and Charles Philippe Leblond. PDF Plant cell biology: The roots of quiescence p754 | doi:10.1038/nrm3707 The ERF115 transcriptional activator is a rate-limiting factor of quiescent centre cell division. PDF IN BRIEF Development: Multiciliogenesis from scratch | Autophagy: Selective degradation of P granule components | Exocytosis: A sortilin for secretory granules | Cell migration: Putting a brake for cells to turn | Morphogenesis: New action in the lumen | Cell division: Nuclear pore inheritance PDF Molecular Cell Biology JOBS of the week Postdoctoral Research Associate in Cell Biology and Molecular Genetics The Scripps Reseach Institute Tenure track Assistant Professor in Cell & Molecular Biology West Chester University PhD Programme in Molecular Cell Biology Medical Research Council - Laboratory for Molecular Cell Biology Postdoc position-plant molecular biology Texas Tech University Postdoctoral Research Fellow Brigham & Women's Hospital - Harvard Medical School More Science jobs from Molecular Cell Biology EVENT Keystone Symposia: Molecular Cell Biology of Macrophages in Human Diseases 09.02.14 New Mexico, USA More science events from
FOREWORD		Top
Size and position matter Graham Warren p755 | doi:10.1038/nrm3705 Abstract | Full Text | PDF
Focus on: Organelle biogenesis and homeostasis REVIEWS Top The autophagosome: origins unknown, biogenesis complex Christopher A. Lamb, Tamotsu Yoshimori & Sharon A. Tooze p759 | doi:10.1038/nrm3696 Autophagosome biogenesis starts at the isolation membrane (also called the phagophore). Our understanding of the molecular processes that initiate the isolation membrane, the membrane sources from which this membrane originates and how it is expanded to the autophagosome membrane by autophagy-related (ATG) proteins and the vesicular trafficking machinery, is increasing. Abstract | Full Text | PDF The biophysics and cell biology of lipid droplets Abdou Rachid Thiam, Robert V. Farese Jr & Tobias C. Walther p775 | doi:10.1038/nrm3699 Lipid droplets are intracellular organelles that store oil-based reserves of metabolic energy and components of membrane lipids. Basic biophysical principles of emulsions are important for lipid droplet biology, their formation, growth and shrinkage. Such mechanisms enable cells to use emulsified oil when required. The surfactant composition at the lipid droplet surface is crucial for homeostasis and protein targeting to their surfaces. Abstract | Full Text | PDF Biogenesis and homeostasis of chloroplasts and other plastids Paul Jarvis & Enrique López-Juez p787 | doi:10.1038/nrm3702 Chloroplasts are the ancestral members of the plastid organelle family. Their identity, division and biogenesis require the import of nucleus-encoded proteins and tight coordination between the organellar genetic system and the nucleocytosolic system. The ubiquitin–proteasome system also links plastid homeostasis and biogenesis to organismal development. Abstract | Full Text | PDF Peroxisomes take shape Jennifer J. Smith & John D. Aitchison p803 | doi:10.1038/nrm3700 The control of peroxisome biogenesis by different mechanisms, including de novo generation or growth and fisson of existing peroxisomes, may be coordinated to control peroxisome size and number. Dissecting this process should aid our understanding of how peroxisome dynamics are regulated, with implications for peroxisome-related diseases. Abstract | Full Text | PDF
PERSPECTIVES		Top
TIMELINE 50 years of allosteric interactions: the twists and turns of the models Jean-Pierre Changeux p819 | doi:10.1038/nrm3695 The concept of allosteric interactions between topographically distinct sites, and the subsequent Monod-Wyman-Changeux model proposed in 1965 for the conformational change mediating them, arose around 50 years ago. Many classic regulatory proteins follow this model, which has been expanded and challenged over the years. Abstract | Full Text | PDF
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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