Nature Review Cancer contents December 2013 Volume 13 Number 12 pp 821-892

TABLE OF CONTENTS
December 2013 Volume 13 Number 12		Advertisement
Impact Factor 35 *	In this issue Research Highlights Reviews Perspectives Also this month Calendar: Nature Reviews Cancer Calendar 2014  Featured article: Life history trade-offs in cancer evolution C. Athena Aktipis, Amy M. Boddy, Robert A. Gatenby, Joel S. Brown & Carlo C. Maley	New CLARIOstar® with Triple Technology The CLARIOstar® multimode microplate reader outperforms conventional instruments with triple technology - LVF Monochromators, filters, and an ultra-fast spectrometer ensure no compromise on flexibility or sensitivity. With the CLARIOstar® from BMG LABTECH, anything is possible. Any wavelength. Any bandwidth. Any assay. Learn more at www.bmglabtech.com.
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
WIN 2014 Symposium; Winning combinations for precision cancer medicine Paris, June 23-34, 2014 The WIN 2014 Symposium is an exceptional global event entirely dedicated to breakthrough biomarker investigations and combination therapies for cancer. Major developments in precision cancer medicine will be developed in sessions featuring basic and clinical cancer research. More information here: www.winsymposium.org
Advertisement
Differential expression of chemokine receptors and their roles in cancer imaging (open access) In this review article, Sridhar Nimmagadda provides a survey of chemokine receptor expression in cancer and evaluates the potential of chemokine receptor imaging as a tool for molecular characterization of cancer.  Read more high-quality articles from Frontiers in Oncology
RESEARCH HIGHLIGHTS Top Tumour microenvironment: Destroying leukaemia stem cell habitats p821 | doi:10.1038/nrc3639 The bone marrow microenvironment can support the growth and activity of leukaemia stem cells, and two recent papers suggest several ways in which these interactions might be targeted for therapeutic benefit. PDF Metabolism: Nuclear or cytoplasmic? p822 | doi:10.1038/nrc3630 Two papers examine the nuclear and cytoplasmic function of PKM2. PDF Epigenetics: WIP1 creates hush and havoc p822 | doi:10.1038/nrc3633 A paper by Dmitry Bulavin and colleagues shows that WIP1 is involved in regulating DNA methylation-mediated silencing of heterochromatin and might contribute to C-to-T substitutions and mutation load in breast cancers. PDF Stem cells: As directed p824 | doi:10.1038/nrc3629 A paper in Cell Stem Cell that uses lineage tracing in the pituitary shows that, although mutations in a subpopulation of stem cells can induce tumour formation, the tumour cells do not arise from the mutated stem cells. PDF Signalling: Finding the GAPs in mTORC1 signalling p824 | doi:10.1038/nrc3632 A new study identifies the tumour suppressor folliculin as a GTPase-activating protein that regulates the nucleotide status of the RAG proteins, which are important regulators of mTOR complex 1 kinase activity. PDF Bladder cancer: No cohesion for cohesin's role p825 | doi:10.1038/nrc3631 Three papers report the discovery of recurring deleterious mutations in the cohesin subunit STAG2 in urothelial bladder cancers, but the evidence for the contribution of STAG2 loss to aneuploidy is conflicting. PDF IN BRIEF Signalling: An original SIN1 | Genetics: Bespoke mutations | Immunotherapy: Improved efficacy | Genomics: X marks the spot PDF Cancer JOBS of the week Postdoc in pancreatic cancer research The University of Texas Health Science Center at San Antonio Postdoctoral fellow in cancer biology University of Oslo Research Pathologist (Cancer Research) National University of Singapore, Cancer Science Institute of Singapore Cancer Biology Postdoctoral Scientist Dana-Farber Cancer Institute / Harvard Medical School Postdoctoral position in cancer epigenetics IRCAN More Science jobs from Cancer EVENT American Association for Cancer Research Annual Meeting 2014 09.04.14 San Diego, USA More science events from
REVIEWS		Top
bHLH–PAS proteins in cancer David C. Bersten, Adrienne E. Sullivan, Daniel J. Peet & Murray L. Whitelaw p827 | doi:10.1038/nrc3621 Mammalian basic HLH (helix–loop–helix)–PER–ARNT–SIM (bHLH–PAS) proteins are heterodimeric transcription factors. Recently determined structures of their PAS domains and successful small-molecule screening programmes are now providing new opportunities to discover selective agonists and antagonists directed against this multitasking family of transcription factors. Abstract | Full Text | PDF
Immunity, inflammation and cancer: a leading role for adenosine Luca Antonioli, Corrado Blandizzi, Pál Pacher & György Haskó p842 | doi:10.1038/nrc3613 Several studies have recently highlighted a crucial role for adenosine signalling in regulating various aspects of the cell-intrinsic and cell-extrinsic processes of cancer development. This Review critically discusses adenosine and its effects on immune, endothelial and cancer cells during the course of neoplastic disease. Abstract | Full Text | PDF
Crossing the endothelial barrier during metastasis Nicolas Reymond, Bárbara Borda d'Água & Anne J. Ridley p858 | doi:10.1038/nrc3628 The processes of intravasation and extravasation are thought to be crucial for cancer cell dissemination and metastasis. This Review describes how cancer cells cross the endothelial barrier, with a focus on the extravasation step. Abstract | Full Text | PDF
VEGF targets the tumour cell Hira Lal Goel & Arthur M. Mercurio p871 | doi:10.1038/nrc3627 The roles of vascular endothelial growth factor (VEGF) in cancer go beyond effects on the vasculature. VEGF signalling in tumour cells, which is mediated by VEGF receptor tyrosine kinases and the neuropilins, contributes to many aspects of tumorigenesis, as highlighted in this Review. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Life history trade-offs in cancer evolution C. Athena Aktipis, Amy M. Boddy, Robert A. Gatenby, Joel S. Brown & Carlo C. Maley p883 | doi:10.1038/nrc3606 Evolutionary life history theory posits that some organisms reproduce rapidly whereas others invest more resources in survival. This framework might help us to understand the diversity of phenotypes that are displayed by tumour cells, including stem cell-like phenotypes, and could have important clinical implications. Abstract | Full Text | PDF
Advertisement
Nature Collections TCGA pan-cancer analysis The Cancer Genome Atlas Pan-cancer initiative examines the similarities and differences among the genomic and cellular alterations found in the first dozen tumor types to be profiled by TCGA. This first look across cancer offers new tools in genomics and bioinformatics and the prospect of repurposing targeted therapies directed by the molecular pathology of the tumors in addition to their clinical classification. Access the Collection and accompanying Podcast, FREE at: www.nature.com/tcga Produced with support from Illumina
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2012 Journal Citation Report (Thomson Reuters, 2013)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.