Molecular Systems Biology - New articles published 26 November 2013

Latest Articles 26th November 2013   Featured Article Research Article News and Views   Web feeds About Open access Advertisement Molecular Systems Biology  - Resources Phylogenetic mapping of disease-pathway proteins   A map of cell type-specific auxin responses  Mammalian gene regulatory network mapping  Functional HDAC interactome landscape           Featured Article Transcriptional regulation is insufficient to explain substrate-induced flux changes in Bacillus subtilis Regulation of enzyme expression is one key mechanism by which cells control their metabolic programs. In this work, a quantitative analysis of metabolism in a model bacterium under different conditions shows that expression alone cannot explain the majority of the observed metabolic changes. Victor Chubukov, Markus Uhr, Ludovic Le Chat, Roelco J Kleijn, Matthieu Jules, Hannes Link, Stephane Aymerich, Jörg Stelling & Uwe Sauer Molecular Systems Biology 9:709; doi:10.1038/msb.2013.66; published 26 November 2013 Full Text | PDF | Supp. Inf. | Review Process Research Article Metabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii The first metabolic reconstruction for Toxoplasma gondii ‘iCS382’ is presented. Model simulations and drug assays identified strain-specific differences in growth rates that may reflect an evolutionary strategy, potentiating broad host range. Carl Song, Melissa A Chiasson, Nirvana Nursimulu, Stacy S Hung, James Wasmuth, Michael E Grigg & John Parkinson Molecular Systems Biology 9:708; doi:10.1038/msb.2013.62; published 19 November 2013 Full Text | PDF | Supp. Inf. | Review Process News and Views Imaging the transcriptome Timothée Lionnet Molecular Systems Biology 9:710; doi:10.1038/msb.2013.67; published 26 November 2013 Full Text | PDF     You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.