Laboratory Investigation - Table of Contents alert Volume 93 Issue 12

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TABLE OF CONTENTS Volume 93, Issue 12 (December 2013) In this issue Inside LI Editorial Research Articles Sign up for e-alerts Recommend to your library Web feed Subscribe Inside LI Top Inside Li 2013 93: 1260-1261; 10.1038/labinvest.2013.131 Full Text Editorial Top Finding a new generation of spies and manuscript reviewers Catherine M Ketcham, Robert W Hardy, Brian P Rubin and Gene P Siegal 2013 93: 1262-1264; 10.1038/labinvest.2013.125 Abstract | Full Text Research Articles Top ORAL AND GASTROINTESTINAL SYSTEMS Low doses of Celecoxib attenuate gut barrier failure during experimental peritonitis This paper reveals the role of cyclooxygenase-2 (COX-2), a key enzyme in the production of inflammatory prostanoids, in gut barrier failure during experimental peritonitis. High levels of COX-2-derived prostaglandin E2 are found in the mucosa during peritonitis and contribute to gut barrier failure, presumably by compromising tight junctions. Low doses of specific COX-2 inhibitors such as celecoxib blunt this effect while preserving the homeostatic function of COX-2-derived prostanoids, and may therefore be useful as an adjunct barrier-protecting therapy. Scott S Short, Jin Wang, Shannon L Castle, G Esteban Fernandez, Nancy Smiley, Michael Zobel, Elizabeth M Pontarelli, Stephanie C Papillon, Anatoly V Grishin and Henri R Ford 2013 93: 1265-1275; advance online publication, October 14, 2013; 10.1038/labinvest.2013.119 Abstract | Full Text Expression of KIAA0101 protein is associated with poor survival of esophageal cancer patients and resistance to cisplatin treatment in vitro KIAA0101 is a protein involved in the regulation of DNA repair, cell cycle progression, and migration. Its elevated expression in esophageal cancer is associated with resistance to chemotherapy, recurrence, and poor survival. This paper shows that in esophageal cancer, KIAA0101 enhances cell proliferation, increases resistance to cisplatin treatment, and alters chromosome stability. These findings suggest KIAA0101 as a target for therapy. Yao Cheng, Kang Li, Dongmei Diao, Kun Zhu, Lei Shi, Hao Zhang, Dawei Yuan, Qi Guo, Xuandi Wu, Di Liu and Chengxue Dang 2013 93: 1276-1287; advance online publication, October 21, 2013; 10.1038/labinvest.2013.124 Abstract | Full Text HEPATIC AND PANCREATIC SYSTEMS Role of cysteinyl-leukotrienes for portal pressure regulation and liver damage in cholestatic rat livers This paper explores the role of Kupffer cell (KC )-mediated pathways in the production and secretion of cysteinyl-leukotrienes (Cys-LT) in cholestatic liver injury. The authors show that KC activation by toll-like receptor ligands results in Cys-LT-mediated microcirculatory alterations in acute cholestasis, and that the degree of cell injury can be attenuated by treatment with a 5-lipoxygenase inhibitor. These findings indicate that treatment with Cys-LT inhibitors may be useful for treatment of cholestatic liver damage. Mark op den Winkel, Leonore Gmelin, Julia Schewe, Natalie Leistner, Manfred Bilzer, Burkhard Göke, Alexander L Gerbes and Christian J Steib 2013 93: 1288-1294; advance online publication, September 23, 2013; 10.1038/labinvest.2013.115 Abstract | Full Text Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury Endoplasmic reticulum (ER) stress is implicated in the pathogenesis of alcoholic and non-alcoholic fatty liver disease. Iron may induce cellular organelle injury via oxidative stress and may perturb ER function. The authors evaluated the role of iron in modulating ER stress-related pathways in liver injury caused by alcohol and diet-induced obesity in a mouse genetically inclined to iron overload. A small increase in hepatic iron synergistically exacerbates the hepatotoxic effects of alcohol and obesity by modulating the cellular stress response pathways. These results suggest that iron chelating agents may be useful as antifibrotic therapies. Terrence C H Tan, Darrell H G Crawford, Lesley A Jaskowski, V Nathan Subramaniam, Andrew D Clouston, Denis I Crane, Kim R Bridle, Gregory J Anderson and Linda M Fletcher 2013 93: 1295-1312; advance online publication, October 14, 2013; 10.1038/labinvest.2013.121 Abstract | Full Text A novel mouse model of nonalcoholic steatohepatitis with significant insulin resistance This study characterizes a new mouse model of nonalcoholic steatohepatitis (NASH) induced by dietary supplementation of conjugated linoleic acid. The treated animals display the harmful effects of trans-fatty acid consumption and exhibit significant insulin resistance along with the typical histopathologic presentation and metabolic abnormalities seen in human NASH. Yuriko Adkins, Iwan W Schie, Dawn Fedor, Aurosis Reddy, Samantha Nguyen, Ping Zhou, Darshan S Kelley and Jian Wu 2013 93: 1313-1322; advance online publication, October 21, 2013; 10.1038/labinvest.2013.123 Abstract | Full Text SOFT TISSUE AND BONE, HEAD AND NECK CK8 phosphorylation induced by compressive loads underlies the downregulation of CK8 in human disc degeneration by activating protein kinase C The underlying mechanism of cytokeratin 8 (CK8) down-regulation in intervertebral disc degeneration remains elusive. This paper clarifies that compressive loads contribute to the protein kinase C-dependent phosphorylation and disassembly of CK8 in the disc. This finding may lead to better treatment for lower back pain and prevention of disk herniation. Zhen Sun, Yun-Shan Guo, Shi-Ju Yan, Zhong-Yuan Wan, Bo Gao, Long Wang, Zhi-Heng Liu, Yang Gao, Dino Samartzis, Li-Feng Lan, Hai-Qiang Wang and Zhuo-Jing Luo 2013 93: 1323-1330; advance online publication, October 28, 2013; 10.1038/labinvest.2013.122 Abstract | Full Text Stem cell self-renewal factors Bmi1 and HMGA2 in head and neck squamous cell carcinoma: clues for diagnosis The proto-oncogenic chromatin regulators Bmi-1 and HMGA2 are expressed in head and neck squamous cell carcinoma. This study shows that Bmi-1 is found primarily in the early cancerous region and that HMGA2 is expressed in the area of tumor progression. These findings suggest that Bmi-1 is a marker for early detection and may help distinguish cancerous from non-cancerous regions, while HMGA2 may be an indicator of prognosis. Hiroshi Yamazaki, Taisuke Mori, Masaki Yazawa, Akiko M Maeshima, Fumihiko Matsumoto, Seiichi Yoshimoto, Yoshihide Ota, Akihiro Kaneko, Hitoshi Tsuda and Yae Kanai 2013 93: 1331-1338; advance online publication, October 21, 2013; 10.1038/labinvest.2013.120 Abstract | Full Text ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS Hypercapnic acidosis confers antioxidant and anti-apoptosis effects against ventilator-induced lung injury Mechanical ventilation can cause pathological changes in lung tissue. This paper shows that hypercapnic acidosis signi?cantly decreases lung vascular leakage and the injury caused by in?ammatory cytokines and oxidative stress in a model of high-pressure ventilation-induced acute lung injury. The mechanism for these effects involves the reduction of inflammation and apoptosis via inhibition of the ASK1/JNK pathway and p38 MAP kinase phosphorylation. Wan-Chao Yang, Chun-Yu Song, Nan Wang, Li-Li Zhang, Zi-Yong Yue, Xiao-Guang Cui and Hua-Cheng Zhou 2013 93: 1339-1349; advance online publication, October 14, 2013; 10.1038/labinvest.2013.118 Abstract | Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. 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