Nature Reviews Molecular Cell Biology contents November 2013 Volume 14 Number 11 pp687-748

Advertisement
Frontiers in Molecular Biosciences is launching soon and sending out a call to active researchers and experts in biology, chemistry and related disciplines to help us build a dynamic, highly regarded editorial board! We're looking for a Specialty Chief Editor for Structural Biology, amongst other key specialities in this field.  Be a part of the future of research publication.
TABLE OF CONTENTS
November 2013 Volume 14 Number 11
Impact Factor 37.162 *	In this issue Research Highlights Progress Reviews Also this month Article series: Cell death and autophagy  Featured article: Functions and mechanics of dynein motor proteins Anthony J. Roberts, Takahide Kon, Peter J. Knight, Kazuo Sutoh & Stan A. Burgess
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Nature Reviews Molecular Cell Biology  FOCUS ON QUALITY CONTROL Through exposure to internal and environmental stresses, cells are continuously at risk of accumulating molecular damage that could impair their functions. Thus, they have evolved protective quality control systems to either prevent errors from occurring, or, if damage has occurred, to detect abnormal macromolecules and initiate their repair or degradation.
RESEARCH HIGHLIGHTS Top Cytoskeleton: Autophagy and ciliogenesis come together p687 | doi:10.1038/nrm3686 A reciprocal relationship between autophagy and ciliogenesis is revealed. PDF Nuclear organization: Processing at the pore p688 | doi:10.1038/nrm3682 Specific nuclear pore complex proteins mediate processing of RNA polymerase III-generated transcripts. PDF Gene expression: RNA granules: the clock within p688 | doi:10.1038/nrm3684 Cytoplasmic RNA granules control the timing of cyclin B1 translation in oocytes. PDF IN THE NEWS Nobel traffic alert p689 | doi:10.1038/nrm3691 The 2013 Nobel Prize for discoveries in vesicle traffic. PDF Cell signalling: Linking JNK and Hippo signalling p690 | doi:10.1038/nrm3677 JNK activation inhibits Warts and LATS to increase Yorkie and YAP activity. PDF Telomeres: Plan B for staying long p690 | doi:10.1038/nrm3678 TERRAs form RNA-DNA hybrids at telomeres that maintain telomere length in the absence of telomerase. PDF Cell cycle: Making an early decision p691 | doi:10.1038/nrm3687 The commitment of a cell to proliferation or quiescence is determined at the end of the previous cell cycle and directly regulated by p21. PDF Cell cycle: Cyclin A corrections p692 | doi:10.1038/nrm3680 Cyclin A destabilizes kinetochore-microtubule attachments during prometaphase to ensure faithful chromosome segregation. PDF JOURNAL CLUB Mysterious modification of tubulin p692 | doi:10.1038/nrm3685 The discovery of tubulin modification by Tyr. PDF IN BRIEF Development: Working together for the greater good | RNA metabolism: Visualizing RNA splicing | Organelle dynamics: Degrading the signal PDF Molecular Cell Biology JOBS of the week PhD Programme in Molecular Cell Biology Medical Research Council - Laboratory for Molecular Cell Biology PhD student (f / m) Universitätsklinikum Carl Gustav Carus Postdoctoral Scientist Northwestern Univeristy Feinberg School of Medicine/Lurie Children's Research Center Postdoctoral Fellow Louisiana State University PhD student Institute of Physical Chemistry, Polish Academy of Sciences More Science jobs from Molecular Cell Biology EVENT Keystone Symposia: Molecular Cell Biology of Macrophages in Human Diseases 09.02.14 New Mexico, USA More science events from
PROGRESS		Top
To be or not to be assembled: progressing into nuclear actin filaments Robert Grosse & Maria K. Vartiainen p693 | doi:10.1038/nrm3681 It was widely accepted that cytoplasmic actin operates as filaments and nuclear actin is mainly monomeric. Recent progress in the field, including the association of actin filament assembly proteins with nuclear functions and the first direct visualizations of polymerized nuclear actin, forces us to rethink this issue. Abstract | Full Text | PDF
REVIEWS		Top
RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts Sarah Geisler & Jeff Coller p699 | doi:10.1038/nrm3679 In addition to their roles in chromatin regulation, long non-coding RNAs (lncRNAs) are being characterized as regulators of diverse cell biological processes, including post-transcriptional control, organization of scaffolds and cell signalling. These findings add weight to the notion that lncRNAs provide a flexible resource for rapid cellular control. Abstract | Full Text | PDF
Functions and mechanics of dynein motor proteins Anthony J. Roberts, Takahide Kon, Peter J. Knight, Kazuo Sutoh & Stan A. Burgess p713 | doi:10.1038/nrm3667 Fuelled by ATP hydrolysis, dyneins generate force and movement on microtubules in a wealth of biological processes. A model for the mechanochemical cycle of dynein is emerging, in which nucleotide-driven flexing motions within the AAA+ ring of dynein alter the affinity of its microtubule-binding 'stalk' and reshape its mechanical element to generate movement. Abstract | Full Text | PDF | Supplementary information
Article series: Cell death and autophagy Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death Dimitry Ofengeim & Junying Yuan p727 | doi:10.1038/nrm3683 Receptor-interacting protein (RIP1) is a key upstream regulator of signalling pathways that lead to either inflammation or cell death by apoptosis or necroptosis. Recent evidence indicates that the decision between these pathways is regulated by the ubiquitylation and deubiquitylation of RIP1, which determines its interaction with various ubiquitin-binding proteins. Abstract | Full Text | PDF
Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche Guiomar Solanas & Salvador Aznar Benitah p737 | doi:10.1038/nrm3675 It is becoming clear that the stem cells from the mammalian epidermis are more heterogeneous than previously anticipated, comprising populations with specific properties and lineage preferences. There is also evidence of crosstalk between epidermal stem cells and surrounding cell populations to ensure their survival and homeostasis. Abstract | Full Text | PDF
Advertisement
Nature Collections TCGA pan-cancer analysis The Cancer Genome Atlas Pan-cancer initiative examines the similarities and differences among the genomic and cellular alterations found in the first dozen tumor types to be profiled by TCGA. This first look across cancer offers new tools in genomics and bioinformatics and the prospect of repurposing targeted therapies directed by the molecular pathology of the tumors in addition to their clinical classification. Access the Collection and accompanying Podcast, FREE at: www.nature.com/tcga Produced with support from  Illumina
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2011 Journal Citation Report (Thomson Reuters, 2012)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.