EMBO Reports - Table of Contents alert Volume 14 Issue 11, pp 947-1022

TABLE OF CONTENTS November 2013 | Volume 14, Issue 11 Upfront Science & Society Scientific Reports Also new AOP Recommend to your library Web feed Advertisement EMBO Molecular Medicine Web Focus  Advances in Molecular Medicine: Access the Editors' Choice This web focus, which features content from the four EMBO scientific publications, includes recent research and review articles that exemplify a wide range of perspectives on molecular medicine research.  Upfront Top Editorial Dear DORA Academics are increasingly hung up on publication metrics as a way of assessing research output. ‘DORA’ is a bold initiative that aims to reverse this trend. Howy applauds it, and argues the need for a further step Howy Jacobs EMBO reports (2013), 14, 947; 10.1038/embor.2013.157 Full text | PDF Published online: 30 October 2013 Subject Categories: Science Infrastructures & Publishing | Science Policy & Funding Opinion Toward a role model With ever-growing amounts of 'omics data, the challenge is to develop an automatic modelling pipeline that receives as input large-scale data pertaining to the system of interest and outputs a complete, logical model that maximizes the fit to the given data. Roded Sharan EMBO reports (2013), 14, 948; 10.1038/embor.2013.161 Full text | PDF Published online: 15 October 2013 Subject Categories: Technology, Development & Applications Hot off the Press Minding the gaps: metabolomics mends functional genomics Two recent studies in PNAS and Nat Chem Biol highlight the power of modern mass-spectrometry techniques for enzyme discovery applied to microbiology. In so doing, they have uncovered new potential targets for the treatment of tuberculosis. Kyu Rhee EMBO reports (2013), 14, 949 - 950; 10.1038/embor.2013.155 Full text | PDF Published online: 01 October 2013 Subject Categories: Cellular Metabolism | Microbiology & Pathogens Science & Society Top Paving a regulatory pathway for phage therapy The growing problem of antibiotic-resistant bacteria has re-kindled interest in phage-based therapies. Yet, the use of phages to treat life-threatening bacterial infections is held back by the lack of an appropriate regulatory framework for phage therapy. Isabelle Huys, Jean-Paul Pirnay, Rob Lavigne, Serge Jennes, Daniel De Vos, Minne Casteels and Gilbert Verbeken EMBO reports (2013), 14, 951 - 954; 10.1038/embor.2013.163 Full text | PDF Published online: 18 October 2013 Subject Categories: Health & Disease | Societal Issues & Politics Animals in research: a stony road The EU Directive on the use of animals in research should now be law across Europe. However, some countries have yet to implement the directive and scientists still fear that it might hinder research. Marta Paterlini EMBO reports (2013), 14, 955 - 958; 10.1038/embor.2013.156 Full text | PDF Published online: 18 October 2013 Subject Categories: Societal Issues & Politics A Mobius strip of scientific imagination From H.G. Wells to Star Trek, science fiction and science have had a long and fruitful relationship. But does science drive the imagination of authors, or do authors drive the imaginations of scientists? Paige Brown EMBO reports (2013), 14, 959 - 963; 10.1038/embor.2013.154 Full text | PDF Published online: 11 October 2013 Subject Categories: Philosophy & History of Science | Technology, Development & Applications Molecular fossils probe life's origins Molecular fossils allow evolutionary biologists to look deep into the history of life on the Earth, far beyond the fossil record and possibly to the first living organisms. Philip Hunter EMBO reports (2013), 14, 964 - 967; 10.1038/embor.2013.162 Full text | PDF Published online: 15 October 2013 Subject Categories: Evolution, Environment & Agriculture Scientific Reports Top Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro Miro is a calcium-binding GTPase at the regulatory nexus of mitochondrial transport and autophagy. Rice and colleagues now present the first structures of Miro, revealing a novel EF hand domain arrangement and EF hand/GTPase interface, and suggest structural mechanisms for the regulation of mitochondrial function. Julian L Klosowiak, Pamela J Focia, Srinivas Chakravarthy, Eric C Landahl, Douglas M Freymann and Sarah E Rice EMBO reports (2013), 14, 968 - 974; 10.1038/embor.2013.151 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 September 2013 Subject Categories: Structural Biology The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair This study shows that SENP7 removes SUMO from KAP1, regulating the interaction of CHD3 with chromatin. In the presence of CHD3, SENP7 is required for chromatin relaxation in response to DNA damage, the ensuing repair and resistance to DNA damaging agents. Alexander J Garvin, Ruth M Densham, Sarah A Blair-Reid, Kenny M Pratt, Helen R Stone, Daniel Weekes, Kirsty J Lawrence and Joanna R Morris EMBO reports (2013), 14, 975 - 983; 10.1038/embor.2013.141 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 September 2013 Subject Categories: Chromatin & Transcription | Proteins | Genome Stability & Dynamics Cohesin and the nucleolus constrain the mobility of spontaneous repair foci The mobility of damaged DNA in the nucleus varies depending on the type of damage. The tethering of sister chromatids to each other limits the mobility of damaged DNA, which probably enhances repair by recombination between sisters. Vincent Dion, Véronique Kalck, Andrew Seeber, Thomas Schleker and Susan M Gasser EMBO reports (2013), 14, 984 - 991; 10.1038/embor.2013.142 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 September 2013 Subject Categories: Genome Stability & Dynamics Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein Bim is crucial for initiating apoptosis and it had been suggested that its expression is regulated by Foxo3a. This report shows that in vivo, the regulation of Bim by Foxo transcription factors is not required for the killing of haematopoietic cells. Marco J Herold, Leona Rohrbeck, Mathias J Lang, Raelene Grumont, Steve Gerondakis, Lin Tai, Philippe Bouillet, Thomas Kaufmann and Andreas Strasser EMBO reports (2013), 14, 992 - 998; 10.1038/embor.2013.152 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 24 September 2013 Subject Categories: Differentiation & Death Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23  EMBO Open Neutrophils are shown to express ChemR23 and respond to C15, which inhibits integrin activation and clustering, reducing neutrophil adhesion and chemotaxis in vitro, and neutrophil recruitment and heart damage in a murine myocardial infarction model. Jenna L Cash, Stefania Bena, Sarah E Headland, Simon McArthur, Vincenzo Brancaleone and Mauro Perretti EMBO reports (2013), 14, 999 - 1007; 10.1038/embor.2013.138 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 September 2013 Subject Categories: Immunology A transient reversal of miRNA-mediated repression controls macrophage activation During macrophage activation, cytokine mRNAs are translated despite high levels of counteracting miRNAs. Here, phosphorylation of Ago2 is shown to impair its binding to miRNAs and cognate mRNAs, enabling macrophage activation and prevention of pathogen invasion. Anup Mazumder, Mainak Bose, Abhijit Chakraborty, Saikat Chakrabarti and Suvendra N Bhattacharyya EMBO reports (2013), 14, 1008 - 1016; 10.1038/embor.2013.149 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 September 2013 Subject Categories: RNA | Immunology | Microbiology & Pathogens Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice Mouse models of Alzheimer disease have distinct types of amyloid deposit. Injecting brain extracts from one model into another, or from old mice into young, the study shows that the type of aggregated Aß can be maintained by seeded conversion. Götz Heilbronner, Yvonne S Eisele, Franziska Langer, Stephan A Kaeser, Renata Novotny, Amudha Nagarathinam, Andreas Åslund, Per Hammarström, K Peter R Nilsson and Mathias Jucker EMBO reports (2013), 14, 1017 - 1022; 10.1038/embor.2013.137 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 September 2013 Subject Categories: Molecular Biology of Disease | Neuroscience Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. 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