Nature Biotechnology Contents: Volume 31 pp 571 - 660

Advertisement Discover now Takyon™ qPCR kits for SYBR® and Probes assays. Emerging from the combination of an optimized reaction buffer and a new efficient enzyme, Takyon™ kits ensure sensitivity and fast delivery of accurate and reproducible results! Takyon™ was inspired by the faster than light particle, "Tachyon". TABLE OF CONTENTS July 2013 Volume 31, Issue 7 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Advertisement   Reichert Surface Plasmon Resonance (SPR) systems for protein-protein and small molecule interaction analysis Monitor real-time binding, obtain detailed interaction information: on/off rates, affinity, thermodynamics and concentration. Reichert ultra-sensitive, affordable SPR systems push the detection and sensitivity for label-free definitive analysis.  ReichertSPR.com Japanese table of contents Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Wondering where to publish your next paper?  Frontiers is a community-oriented open-access publisher and research network. We are driving innovations around peer-review and a whole ecosystem of open science tools  Be a part of the future of research publication    Editorial Top Myriad diagnostic concerns   p571 doi:10.1038/nbt.2638 The Myriad decision to overturn human gene patents is the least of concerns for a diagnostic sector struggling to attract investment. News Top Thermo Fisher vies for Life Technologies' sequencing market   pp573 - 574 Mark Ratner doi:10.1038/nbt0713-573 cDNA is patentable, but not genes   p574 Mark Ratner doi:10.1038/nbt0713-574 Investors start backing hearing loss treatments   pp575 - 576 Cormac Sheridan doi:10.1038/nbt0713-575 Innovators under 36, please   p576 Lisa Melton doi:10.1038/nbt0713-576 First microRNA mimic enters clinic   p577 Aaron Bouchie doi:10.1038/nbt0713-577 India blacklisted   p578 Killugudi Jayaraman doi:10.1038/nbt0713-578a Crowdsourced contest identifies best-in-class breast cancer prognostic   pp578 - 580 Michael Eisenstein doi:10.1038/nbt0713-578b GSK shares spoils with Avalon   p579 Brian Orelli doi:10.1038/nbt0713-579a Argentina cuts GM red tape   p579 Lucas Laursen doi:10.1038/nbt0713-579b Court injunction threatens clinical data transparency push   pp581 - 582 Nuala Moran doi:10.1038/nbt0713-581 Around the world in a month   p582 doi:10.1038/nbt0713-582 Fecal transplants to follow FDA rules   p583 Jeffrey L Fox doi:10.1038/nbt0713-583 Obituary Willem 'Pim' Stemmer 1957-2013   p584 James W Larrick, Volker Schellenberger and Carlos F Barbas III doi:10.1038/nbt.2630 A truly original thinker and pioneering entrepreneur. News Feature Banking on cord blood stem cells   pp585 - 588 Sarah Webb doi:10.1038/nbt.2629 New research will shed light on claims from commercial banks that cord blood-derived stem cells can be used in diseases beyond hematological disorders. Sarah Webb investigates. Bioentrepreneur Top Data Page University biotech patenting   p589 Brady Huggett doi:10.1038/nbt.2637 Opinion and Comment Top Correspondence The case for semi-mandatory HPV vaccination in China   pp590 - 591 Wen Jie Zhang, Feng Li, Ying Hong Wang, Dilixia Simayi, Abudukeyoumu Saimaiti et al. doi:10.1038/nbt.2631 Rapid growth of seaweed biotechnology provides opportunities for developing nations   pp591 - 592 Ines Mazarrasa, Ylva S Olsen, Eva Mayol, Nuria Marba and Carlos M Duarte doi:10.1038/nbt.2636 Read and assembly metrics inconsequential for clinical utility of whole-genome sequencing in mapping outbreaks   pp592 - 594 Simon R Harris, M E Torok, Edward J P Cartwright, Michael A Quail, Sharon J Peacock et al. doi:10.1038/nbt.2616 Features Top Genomic testing reaches into the womb   pp595 - 601 Malorye Allison doi:10.1038/nbt.2627 Next-generation sequencing has provided long-sought-after noninvasive tests for prenatal screening, and a small cadre of companies has stepped up to push it into the clinic at warp speed. Patents Bowman v. Monsanto and the protection of patented replicative biologic technologies   pp602 - 606 William J Simmons doi:10.1038/nbt.2625 An important US Supreme Court ruling means that prudent owners, end users and other courts will proceed with caution. Recent patent applications in hematopoietic stem cells   p607 doi:10.1038/nbt.2640 News and Views Top Cracking the code of human T-cell immunity   pp609 - 610 Christopher J Harvey and Kai W Wucherpfennig doi:10.1038/nbt.2626 Combinatorial tetramer staining coupled with mass cytometry allows simultaneous detection of T cells specific for a wide array of peptide epitopes. See also: Research by Newell et al. A window onto siRNA delivery   pp611 - 612 Yuhua Wang and Leaf Huang doi:10.1038/nbt.2634 Two studies trace the intracellular trafficking of siRNA delivered by lipid nanoparticles. See also: Research by Gilleron et al. | Research by Sahay et al. Research Highlights   p612 doi:10.1038/nbt.2628 Organic synthesis by in vitro evolution   pp613 - 614 Peter E Nielsen doi:10.1038/nbt.2632 A method for DNA-templated ligation allows in vitro evolution of organic polymers. Biotechnology JOBS of the week Postdoctoral Researchers, PhD Positions and Senior Bioinformatician at the Max Planck Institutes of Biochemistry and Neurobiology Max Planck Institutes of Biochemistry and Neurobiology Ph.D. Student Position in Biochemistry (Alzheimer's disease) EPFL – Ecole Polytechnique Fédérale de Lausanne Research Associate Baylor College of Medicine (BCM) Postdoctoral positions in Synthetic Biology INRA (French National Agricultural Research Institute) and AgroParisTech (French Graduate School in Technology for Life, Food and Environmental Sciences), UMR914 Nutrition Physiology and Ingestive Behavior Senior Visiting Researcher and Post-Doctoral Program Brazilian Center for Research in Energy and Materials (CNPEM) More Science jobs from Computational Biology Top Analysis Uniform, optimal signal processing of mapped deep-sequencing data   pp615 - 622 Vibhor Kumar, Masafumi Muratani, Nirmala Arul Rayan, Petra Kraus, Thomas Lufkin et al. doi:10.1038/nbt.2596 Optimized algorithms from the field of electrical-signal processing improve the identification of genomic signals from diverse high-throughput sequencing experiments, such as ChIP-seq, DNase-seq and FAIRE-seq. Research Top Articles Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization   pp623 - 629 Evan W Newell, Natalia Sigal, Nitya Nair, Brian A Kidd, Harry B Greenberg et al. doi:10.1038/nbt.2593 An approach involving combinatorial peptide-MHC tetramer staining and mass cytometry allows simultaneous screening of over 100 T-cell specificities in a single human blood sample. See also: News and Views by Harvey & Wucherpfennig Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells   pp630 - 637 Mikko Taipale, Irina Krykbaeva, Luke Whitesell, Sandro Santagata, Jianming Zhang et al. doi:10.1038/nbt.2620 The sensitivity of chaperones to the stability of client proteins is used for kinome-wide profiling of kinase inhibitors. Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape   pp638 - 646 Jerome Gilleron, William Querbes, Anja Zeigerer, Anna Borodovsky, Giovanni Marsico et al. doi:10.1038/nbt.2612 Detailed analyses of siRNA delivery by lipid nanoparticles reveal major pathways of siRNA internalization and endosomal escape. See also: News and Views by Wang & Huang Letters Broad protection against influenza infection by vectored immunoprophylaxis in mice   pp647 - 652 Alejandro B Balazs, Jesse D Bloom, Christin M Hong, Dinesh S Rao and David Baltimore doi:10.1038/nbt.2618 Gene therapy encoding a single influenza broadly neutralizing antibody durably protects even immunocompromised mice from illness caused by diverse influenza strains. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling   pp653 - 658 Gaurav Sahay, William Querbes, Christopher Alabi, Ahmed Eltoukhy, Sovan Sarkar et al. doi:10.1038/nbt.2614 Detailed analyses of siRNA delivery by lipid nanoparticles reveal major pathways of siRNA internalization and endosomal escape. See also: News and Views by Wang & Huang Careers and Recruitment Top Mentors, be nice   p659 Nathan L Vanderford doi:10.1038/nbt.2633 Mentors are essential for the training of PhDs and fellows, but many have lost sight of positive leadership and are just mean. People People   p660 doi:10.1038/nbt.2641 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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