Nature Immunology Contents: July 2013 Volume 14 pp 645-763

Advertisement See what nature is hiding BD Horizon™ Brilliant Violet™ polymer conjugates are brighter than traditional dyes and can help identify cell populations with lower receptor density than previously possible. Learn how to resolve rare and dim cell populations with our expanded set of tools and information and request a free sample at bdbiosciences.com/go/brilliant.  TABLE OF CONTENTS July 2013 Volume 14, Issue 7 Focus Editorial Perspectives Reviews Research Highlights News and Views Articles Resource Advertisement Reichert Technologies Surface Plasmon Resonance: SPR systems for monitoring antibody-antigen interactions   Explore critical interactions label-free and in real time. Reichert SPR returns concentration, kinetics (on/off rates), and affinity data. Reichert's ultra-sensitive, affordable SPR systems provide protein-protein interaction analysis with definitive results.   ReichertSPR.com Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement 2014 Vilcek Prizes for Creative Promise The Vilcek Foundation is seeking young, foreign-born biomedical scientists with drive, talent, and ingenuity to apply for the $35,000 Creative Promise Prizes. Three winners will be selected. Applicants must be 38 years old or younger, have a doctoral degree, and hold a position as principal investigators in an academic or research institution. More at www.vilcek.org   Advertisement Frontiers Research Topics  RTs enable you and your colleagues to drive your field where you want to take it, by encouraging dialogue and collaboration between researchers. A collection of papers in an evolving field around a topic that you choose. Papers submitted are rigorously peer-reviewed and freely available under a CC-BY license.  Your Topic - Your Way - Your Frontiers    Focus Top Focus on The microbiota Focus issue: July 2013 Volume 14 No 7 Contents Editorial Perspective Reviews Research Highlights Interactions between the immune system and microbiota influence local and systemic immune homeostasis. Nature Immunology presents a series of specially commissioned articles that discuss the reciprocal regulation between the host immune system and commensal microbiota, the dynamic interactions between commensals and pathogens, and emerging information on how resident viruses might influence immune homeostasis. The web focus also includes highlights of recent research in this area. Editorial Top Focus on The microbiota The world within   p645 doi:10.1038/ni.2662 Evolutionarily shaped molecular and cellular interactions between bacterial commensals and the host immune system drive a mutually beneficial relationship. Perspectives Top Focus on The microbiota Compartmentalized and systemic control of tissue immunity by commensals   pp646 - 653 Yasmine Belkaid and Shruti Naik doi:10.1038/ni.2604 Focus on The microbiota Resident viruses and their interactions with the immune system   pp654 - 659 Breck A Duerkop and Lora V Hooper doi:10.1038/ni.2614 Reviews Top Focus on The microbiota The role of the immune system in governing host-microbe interactions in the intestine   pp660 - 667 Eric M Brown, Manish Sadarangani and B Brett Finlay doi:10.1038/ni.2611 Focus on The microbiota Innate immune recognition of the microbiota promotes host-microbial symbiosis   pp668 - 675 Hiutung Chu and Sarkis K Mazmanian doi:10.1038/ni.2635 Focus on The microbiota Commensal bacteria at the interface of host metabolism and the immune system   pp676 - 684 Jonathan R Brestoff and David Artis doi:10.1038/ni.2640 Focus on The microbiota Control of pathogens and pathobionts by the gut microbiota   pp685 - 690 Nobuhiko Kamada, Grace Y Chen, Naohiro Inohara and Gabriel Núñez doi:10.1038/ni.2608 Research Highlights Top Focus on The microbiota Share and share alike | IL-22 controls transmissible colitis | Mucosal ILC diversity | Restricting T cell responses | Commensal help | Seeking advantages News and Views Top CIS: the late-blooming eldest son   pp692 - 694 Akihiko Yoshimura doi:10.1038/ni.2645 Members of the SOCS (suppressor of cytokine signaling) family negatively regulate STAT transcription factors. The SOCS family member CIS is now shown to negatively regulate differentiation into the TH2 and TH9 subsets of helper T cells through negative regulation of STAT3, STAT5 and STAT6. See also: Article by Yang et al. A 'GEM' of a cell   pp694 - 695 Mitchell Kronenberg and Dirk M Zajonc doi:10.1038/ni.2644 A third population of human T lymphocytes that express αβ T cell antigen receptors with restricted α-chain diversity has been identified. These cells recognize the lipid glucose monomycolate from Mycobacterium tuberculosis presented by CD1b. See also: Article by Van Rhijn et al. Regulation unmasked by activation   pp696 - 697 Mike Clark and Anne Cooke doi:10.1038/ni.2646 The glycoprotein CD52 is an important target for clinical antibodies, but its receptor and function have remained a mystery. However, it now seems that CD52 may be released in soluble form by a subpopulation of human T cells and may thereby exert an as-yet-unrecognized regulatory function via the inhibitory molecule Siglec-10. See also: Article by Bandala-Sanchez et al. Immunology JOBS of the week Post doctoral fellow in Developmental Immunology Univ of Massachusetts Medical School Immunology Postdoctoral Fellowship Albert Einstein College of Medicine (AECOM) Postdoctoral position-Immunology Northwestern Univeristy Feinberg School of Medicine PhD student Patrizia Agostinis (KULeuven, Belgium) PhD Studentship- Quantitative modelling of key immunological processes is critical for the development of novel therapeutic approaches University of Southampton - Centre for Biological Sciences More Science jobs from Immunology EVENT Tumor Immunology and Immunotherapy 28th Oct 2013 Suzhou, China More science events from Research Highlights Top A DRAM-atic end for T cells | Peripheral fate | Affinity testing | Becoming pandemic | Mast cell-DC axis | Systemic alarmin Advertisement Bio-Plex Pro™ Human Isotyping assays give you a cost-effective and easy-to-use alternative to traditional ELISA., these magnetic bead - based assays form a complete workflow that can accelerate your immunology research. www.bio-rad.com/ad/isotyping   Articles Top Targeting of a natural killer cell receptor family by a viral immunoevasin   pp699 - 705 Richard Berry, Natasha Ng, Philippa M Saunders, Julian P Vivian and Jie Lin et al. doi:10.1038/ni.2605 The mode by which NK cell receptors are bound to their ligands has been unclear. Rossjohn and colleagues show that the cytomegalovirus immunoevasin m157 binds the NK cell receptor Ly49 by its stalk region and not via the expected membrane-distal lectin domain. A conserved human T cell population targets mycobacterial antigens presented by CD1b   pp706 - 713 Ildiko Van Rhijn, Anne Kasmar, Annemieke de Jong, Stephanie Gras and Mugdha Bhati et al. doi:10.1038/ni.2630 Moody and colleagues identify a subset of T cells with high affinity for complexes of CD1b and mycobacterial glycolipids, conserved TCRα use and biased TCRβ use. These 'GEM' T cells show interdonor conservation and proliferate after infection. See also: News and Views by Kronenberg & Zajonc GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling   pp714 - 722 Yunqi Wang, Ichiro Misumi, Ai-Di Gu, T Anthony Curtis and Lishan Su et al. doi:10.1038/ni.2623 The transcription factor GATA-3 is required for the differentiation of mature CD4+ T cells into TH2 cells. Wan and colleagues show that GATA-3 also controls the maintenance and proliferation of CD8+ T cells in the periphery. VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites   pp723 - 731 Paola Larghi, David J Williamson, Jean-Marie Carpier, Stéphanie Dogniaux and Karine Chemin et al. doi:10.1038/ni.2609 How the adaptor Lat and the TCR come together after TCR triggering is not well understood. Hivroz and colleagues show that the vesicular protein VAMP7 is required for the recruitment of Lat-containing vesicles to TCR-activation sites. The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation   pp732 - 740 Xuexian O Yang, Huiyuan Zhang, Byung-Seok Kim, Xiaoyin Niu and Juan Peng et al. doi:10.1038/ni.2633 SOCS proteins suppress cytokine signaling by inhibiting activation of STAT signal transducers. Dong and colleagues show that the SOCS protein CIS is induced by IL-4 to control TH2 and TH9 helper T cell differentiation. See also: News and Views by Yoshimura T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10   pp741 - 748 Esther Bandala-Sanchez, Yuxia Zhang, Simone Reinwald, James A Dromey and Bo-Han Lee et al. doi:10.1038/ni.2610 CD52 is an important target for depleting antibodies; however, its physiological ligand and function have been unclear. Harrison and colleagues show that soluble CD52 is used by certain CD4+ cells to suppress target cells via the inhibitory receptor Siglec-10. See also: News and Views by Clark & Cooke A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells   pp749 - 755 Eric L Fritz, Brad R Rosenberg, Kenneth Lay, Aleksandra Mihailović and Thomas Tuschl et al. doi:10.1038/ni.2616 Additional editing activities for the cytidine deaminase AID beyond immunoglobulin-gene diversification have been proposed. Papavasiliou and colleagues now definitively show that antibody diversification is AID's sole physiological function in activated B cells. Advertisement Join 500+ ADC experts at World ADC San Fran 2013. Hear the latest data & insights fresh from the frontline of the industry, allowing you to design & develop the optimal ADC, faster. Create winning ADC formats which deliver stunning clinical results, advance your CMC strategy & reduce time to market. See more information here: www.adc-summit.com.   Resource Top The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment   pp756 - 763 Elisa Laurenti, Sergei Doulatov, Sasan Zandi, Ian Plumb and Jing Chen et al. doi:10.1038/ni.2615 Dick and colleagues map the transcriptional dynamics of human hematopoietic stem cells and early progenitor populations. The authors show that transcriptional programs are extensively shared, extend across lineage-potential boundaries and are not strictly lineage affiliated. Top Advertisement UCSD Clinical and Translational Research Institute and Nature Medicine present: Bench to Bedside 2013: Cancer Therapeutics November 4-6, 2013 Estancia La Jolla Hotel La Jolla, CA, USA  Click here for more information or to register for this conference today!     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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