Molecular Systems Biology - New articles published 11 June 2013

Latest Articles 11th June 2013   Featured Article Research Article Report News and Views Erratum   Web feeds About Open access Advertisement Integrative Genomics in Microbiology REVIEW - Computational meta’omics for microbial community studies Dissecting specific and global transcriptional regulation of bacterial gene expression Indirect and suboptimal control of gene expression is widespread in bacteria Shared control of gene expression in bacteria by transcription factors and global physiology of the cell     Featured Article The functional interactome landscape of the human histone deacetylase family This study presents the first global protein interaction network for all 11 human HDACs in T cells and an integrative mass spectrometry approach for profiling relative interaction stability within isolated protein complexes. Preeti Joshi, Todd M Greco, Amanda J Guise, Yang Luo, Fang Yu, Alexey I Nesvizhskii & Ileana M Cristea Molecular Systems Biology 9:672; doi:10.1038/msb.2013.26; published 11 June 2013 Full Text | PDF | Supp. Inf. | Review Process Research Article Network quantification of EGFR signaling unveils potential for targeted combination therapy Analysis of the signaling response of colon cancer cells to systematic perturbations reveals an EGF receptor-mediated cross-talk between the MAPK and AKT pathways. Accordingly, the predicted combinatorial treatment is shown to inhibit tumor growth in vivo. Bertram Klinger, Anja Sieber, Raphaela Fritsche-Guenther, Franziska Witzel, Leanne Berry, Dirk Schumacher, Yibing Yan, Pawel Durek, Mark Merchant, Reinhold Schäfer, Christine Sers & Nils Blüthgen Molecular Systems Biology 9:673; doi:10.1038/msb.2013.29; published 11 June 2013 Full Text | PDF | Supp. Inf. | Review Process Report Synthetic mammalian transgene negative autoregulation The effect of negative feedback on global and local sources of uncertainty is studied with synthetic circuits stably integrated in human cells. Negative feedback is shown to be the most efficient way to mitigate the effects of global fluctuations by introducing a single additional regulatory link. Vinay Shimoga, Jacob T White, Yi Li, Eduardo Sontag & Leonidas Bleris Molecular Systems Biology 9:670; doi:10.1038/msb.2013.27; published 4 June 2013 Full Text | PDF | Supp. Inf. | Review Process News and Views The HDAC interaction network Ilana Livyatan & Eran Meshorer Molecular Systems Biology 9:671; doi:10.1038/msb.2013.33; published 11 June 2013 Full Text | PDF Erratum RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells Joanne Chia, Germaine Goh, Victor Racine, Susanne Ng, Pankaj Kumar & Frederic Bard Molecular Systems Biology 9:677; doi:10.1038/msb.2013.34; published 11 June 2013 Full Text | PDF Advertisement Take part in our reader survey for a chance to win a MacBook Air As a reader of NPG's clinical and society-owned journals, we invite you to take part in a survey on your use of our journals and their associated websites. Take the survey and be entered into a prize draw for a MacBook Air* *Terms & conditions apply     You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.