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| | | 19 February 2013 | | | Featured image: | |  | | | Knox et al. show that the neurotrophic factor neurturin enhances regeneration and restores function to irradiated salivary glands. | | | | | | |
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*Apple exchange rates apply to international prices. | | | | | | | Latest Articles | View all Articles | | | | | Ion-association complexes unite classical and non-classical theories for the biomimetic nucleation of calcium phosphate | | | Wouter J. E. M. Habraken, Jinhui Tao, Laura J. Brylka, Heiner Friedrich, Luca Bertinetti, Anna S. Schenk, Andreas Verch, Vladimir Dmitrovic, Paul H. H. Bomans, Peter M. Frederik, Jozua Laven, Paul van der Schoot, Barbara Aichmayer, Gijsbertus de With, James J. DeYoreo and Nico A. J. M. Sommerdijk | | | In many solution systems, nanometre-sized structural units are present before nucleation, but little is known about these pre-nucleation clusters. Habraken et al. show that, for the crystallization of calcium phosphate, these nanometre-sized units are calcium triphosphate complexes. | | | 19 Feb | Nat Commun 4:1507 doi:10.1038/ncomms2490 (2013) | | | Chemical sciences Physical chemistry | | Abstract | Full Text | PDF (2,634 kB) |
Supplementary Information |
| Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface OPEN | | | Lynn Kimlicka, Kelvin Lau, Ching-Chieh Tung and Filip Van Petegem | | | Ryanodine receptors are calcium-release channels located in the membrane of the sarcoplasmic and endoplasmic reticulum. Kimlicka et al. compare pseudo-atomic models of the N-terminal area in the open and closed states and characterize the mutations in the N-terminal that disrupt channel opening. | | | 19 Feb | Nat Commun 4:1506 doi:10.1038/ncomms2501 (2013) | | | Biological sciences Biophysics | | Abstract | Full Text | PDF (2,985 kB) |
Supplementary Information |
| Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics OPEN | | | Hong-Won Lee, Taeyoon Kyung, Janghyun Yoo, Tackhoon Kim, Chaeuk Chung, Ji Young Ryu, Hanki Lee, Kihyun Park, Sangkyu Lee, Walton D. Jones, Dae-Sik Lim, Changbong Hyeon, Won Do Heo and Tae-Young Yoon | | | Co-immunoprecipitation provides static and qualitative information about protein–protein interactions. Lee et al. create real-time movies of single protein–protein interactions during co-immunoprecipitation, and use them to assess the dynamics of mutant Ras proteins derived from tumours. | | | 19 Feb | Nat Commun 4:1505 doi:10.1038/ncomms2507 (2013) | | | Biological sciences Biophysics | | | | Abstract | Full Text | PDF (925 kB) |
Supplementary Information |
| Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo | | | Greg M. Thurber, Katy S. Yang, Thomas Reiner, Rainer H. Kohler, Peter Sorger, Tim Mitchison and Ralph Weissleder | | | Current pharmacokinetic models describe the distribution of drugs within tissues but usually lack single-cell resolution. Here Weissleder and colleagues visualize the subcellular distribution of an anticancer drug in real time in living animals and develop a model to extrapolate these findings to humans. | | | 19 Feb | Nat Commun 4:1504 doi:10.1038/ncomms2506 (2013) | | | Abstract | Full Text | PDF (2,788 kB) |
Supplementary Information |
| A synthetic nanomaterial for virus recognition produced by surface imprinting | | | Alessandro Cumbo, Bernard Lorber, Philippe F.-X. Corvini, Wolfgang Meier and Patrick Shahgaldian | | | The recognition of viruses by synthetic materials is historically difficult. Here, a templating procedure using silica nanoparticles coated with organosilanes is used to form virus-imprinted particles, possessing both shape and chemical imprints, capable of virus recognition at picomolar concentrations. | | | 19 Feb | Nat Commun 4:1503 doi:10.1038/ncomms2529 (2013) | | | Biological sciences Chemical sciences | | | Materials science Nanotechnology | | | Virology | | | Abstract | Full Text | PDF (750 kB) |
| DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes | | | Lin Liu, Subhajyoti De and Franziska Michor | | | Human cancer genomes often contain large amounts of single-nucleotide substitutions (SNS). Liu et al. catalogued SNS signatures across various cancer and normal genomes, demonstrating coordinative effects between replication timing and nuclear architecture on SNS patterns in cancer genomes. | | | 19 Feb | Nat Commun 4:1502 doi:10.1038/ncomms2502 (2013) | | | Biological sciences Bioinformatics | | | Cancer Genetics | | Abstract | Full Text | PDF (432 kB) |
Supplementary Information |
| Observation of longitudinal and transverse self-injections in laser-plasma accelerators | | | S. Corde, C. Thaury, A. Lifschitz, G. Lambert, K. Ta Phuoc, X. Davoine, R. Lehe, D. Douillet, A. Rousse and V. Malka | | | Laser-plasma accelerators can produce giga electronvolt energy electrons over centimetre scales, but their properties depend on the initial injection into the accelerator. Corde et al. study self-injection of electrons into the plasma wake and identify both transverse and longitudinal injection mechanisms. | | | 19 Feb | Nat Commun 4:1501 doi:10.1038/ncomms2528 (2013) | | | Physical sciences Applied physics | | | Fluids and plasma physics | | | Abstract | Full Text | PDF (853 kB) |
| Gated silicene as a tunable source of nearly 100% spin-polarized electrons | | | Wei-Feng Tsai, Cheng-Yi Huang, Tay-Rong Chang, Hsin Lin, Horng-Tay Jeng and A. Bansil | | | Silicene is a silicon-based analogue of graphene, but with subtle and potentially useful differences. Wei-Feng Tsai and colleagues show that these differences could be exploited to build electrically-gated silicene devices that generate and control spin-polarized currents with near perfect efficiency. | | | 19 Feb | Nat Commun 4:1500 doi:10.1038/ncomms2525 (2013) | | | Physical sciences Condensed matter | | | Theoretical physics | | Abstract | Full Text | PDF (461 kB) |
Supplementary Information |
| Increased ventilation of Antarctic deep water during the warm mid-Pliocene OPEN | | | Zhongshi Zhang, Kerim H. Nisancioglu and Ulysses S. Ninnemann | | | It is thought that during the mid-Pliocene warm period the Atlantic Meridional Overturning Circulation (AMOC) must have been stronger than today. Here, using proxy data compilation and simulation, Zhang et al. show that the two observations used to support stronger AMOC may not necessitate its increased strength. | | | 19 Feb | Nat Commun 4:1499 doi:10.1038/ncomms2521 (2013) | | | Earth sciences Climate science | | | | Abstract | Full Text | PDF (630 kB) |
Supplementary Information |
| Surface-passivated GaAsP single-nanowire solar cells exceeding 10% efficiency grown on silicon | | | Jeppe V. Holm, Henrik I. Jørgensen, Peter Krogstrup, Jesper Nygård, Huiyun Liu and Martin Aagesen | | | The use of III-V semiconductor nanowires can overcome the need for lattice matching in multi-junction solar cells, which restricts the choice of materials and their bandgaps. This work demonstrates efficient solar cells with GaAsP single nanowires with tunable bandgap and grown on low-cost Si substrates. | | | 19 Feb | Nat Commun 4:1498 doi:10.1038/ncomms2510 (2013) | | | Physical sciences Applied physics | | | Nanotechnology | | Abstract | Full Text | PDF (607 kB) |
Supplementary Information |
| GaAs nanopillar-array solar cells employing in situ surface passivation OPEN | | | Giacomo Mariani, Adam C. Scofield, Chung-Hong Hung and Diana L. Huffaker | | | Arrays of III–V semiconductor nanopillars are promising photovoltaic materials due to their favourable optical properties, however, they show low power conversion efficiencies. Mariani et al. fabricate a GaAs nanopillar solar cell achieving an efficiency of 6.63% owing to surface passivation. | | | 19 Feb | Nat Commun 4:1497 doi:10.1038/ncomms2509 (2013) | | | Physical sciences Applied physics | | | Nanotechnology | | Abstract | Full Text | PDF (1,632 kB) |
Supplementary Information |
| Cell wall elongation mode in Gram-negative bacteria is determined by peptidoglycan architecture OPEN | | | Robert D. Turner, Alexander F. Hurd, Ashley Cadby, Jamie K. Hobbs and Simon J. Foster | | | Bacterial cell wall peptidoglycan is essential for viability and shape determination. Using high-resolution microscopy, Foster and colleagues elucidate the peptidoglycan architecture and insertion pattern in Escherichia coli and other Gram-negative bacteria, and propose a new model for cell wall elongation. | | | 19 Feb | Nat Commun 4:1496 doi:10.1038/ncomms2503 (2013) | | | Biological sciences Microbiology | | | Cell biology | | Abstract | Full Text | PDF (3,928 kB) |
Supplementary Information |
| Smoking exacerbates amyloid pathology in a mouse model of Alzheimer's disease | | | Ines Moreno-Gonzalez, Lisbell D. Estrada, Elisabeth Sanchez-Mejias and Claudio Soto | | | A link between smoking and the incidence of Alzheimer's disease has been implicated in humans. In this study, transgenic mouse models of Alzheimer's disease exposed to cigarette smoke display increased disease abnormalities in the brain, such as amyloidogenesis, neuroinflammation and tau phosphorylation. | | | 19 Feb | Nat Commun 4:1495 doi:10.1038/ncomms2494 (2013) | | | Biological sciences Medical research | | | Neuroscience | | | Abstract | Full Text | PDF (1,827 kB) |
| Parasympathetic stimulation improves epithelial organ regeneration | | | Sarah M. Knox, Isabelle M. A. Lombaert, Candace L. Haddox, Shaun R. Abrams, Ana Cotrim, Adrian J. Wilson and Matthew P. Hoffman | | | Irradiation treatment for cancer therapy often causes irreparable damage to adult organs. Knox and colleagues study irradiated mouse submandibular salivary glands and find that restoring parasympathetic nerve function with the neurotrophic factor neurturin improves regeneration. | | | 19 Feb | Nat Commun 4:1494 doi:10.1038/ncomms2493 (2013) | | | Biological sciences Medical research | | | Neuroscience | | Abstract | Full Text | PDF (1,458 kB) |
Supplementary Information |
| Cleavage-based signal amplification of RNA | | | Yongyun Zhao, Li Zhou and Zhuo Tang | | | RNA detection is important in biomedical research and largely relies on the reverse transcription–PCR reaction. Zhao et al. report an isothermal reaction, which involves cleavage by a DNAzyme and signal amplification, to simultaneously amplify and detect RNA. | | | 19 Feb | Nat Commun 4:1493 doi:10.1038/ncomms2492 (2013) | | | Biological sciences Chemical biology | | Abstract | Full Text | PDF (1,085 kB) |
Supplementary Information |
| Self-similarity of contact line depinning from textured surfaces OPEN | | | Adam T. Paxson and Kripa K. Varanasi | | | The motion of liquid drops on surfaces is governed by adhesion forces, but the microscopic mechanism is unclear. Paxson et al. image the dynamic distortion of the edge of a droplet as it moves across a surface, allowing them to predict the wetting ability of different hierarchically textured surfaces. | | | 19 Feb | Nat Commun 4:1492 doi:10.1038/ncomms2482 (2013) | | | Physical sciences Fluids and plasma physics | | | Abstract | Full Text | PDF (3,880 kB) |
Supplementary Information |
| Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors | | | Christopher J. Vavricka, Yue Liu, Hiromasa Kiyota, Nongluk Sriwilaijaroen, Jianxun Qi, Kosuke Tanaka, Yan Wu, Qing Li, Yan Li, Jinghua Yan, Yasuo Suzuki and George F. Gao | | | New influenza neuramidase inhibitors may increase preparedness against influenza outbreaks. Vavricka et al. confirm the catalytic mechanism of neuramidase and show that it can be inhibited irreversibly with covalent inhibitors. | | | 19 Feb | Nat Commun 4:1491 doi:10.1038/ncomms2487 (2013) | | | Chemical sciences Medicinal chemistry | | | Virology | | | Abstract | Full Text | PDF (1,093 kB) | | | | | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
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