Nature Chemical Biology Contents: March 2013 Volume 9 Number 3, pp 135 - 192

TABLE OF CONTENTS March 2013 Volume 9, Issue 3 Editorial Correspondence Research Highlights News and Views Review Brief Communications Articles Addendum Corrigendum Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Reprint Collection on Epigenetics This collection of articles focuses on histone methylation, its links to human disease and the development of chemical modulators of histone methylation states as leads for chromatin-targeted drug discovery. Produced exclusively with support from:   Editorial Top Authors on the record   p135 doi:10.1038/nchembio.1201 Publication of a paper initiates the process of scientific exchange that requires the ongoing participation of authors. Correspondence Top Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases   pp136 - 137 Fanny L Cherblanc, Kathryn L Chapman, Robert Brown and Matthew J Fuchter doi:10.1038/nchembio.1187 See also: Correspondence by Greiner et al. Reply to "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases"   p137 Dorothea Greiner, Tiziana Bonaldi, Ragnhild Eskeland, Ernst Roemer and Axel Imhof doi:10.1038/nchembio.1188 See also: Correspondence by Cherblanc et al. Research Highlights Top Cancer: Priority targets | Synthesis: A radical way of thinking | Photosynthesis: Elusive reductase found | Enzymes: Specificity swap | Antibiotic mechanisms: PAS is doubly poisonous | Pluripotency: Oleate dependency | Neurobiology: A pain paradox | Metabolism: AMPing up life News and Views Top Receptors: Chemical courtship in mice   pp140 - 141 Charles W Luetje doi:10.1038/nchembio.1180 Physiologically relevant ligands for mammalian odorant receptors have been elusive. A mouse odorant receptor-based bioassay has now been used to guide purification and identification of a natural ligand that mediates attraction of female mice to male urine. See also: Brief Communication by Yoshikawa et al. Protein-protein interactions: A PUMA mechanism unfolds   pp141 - 143 Loren D Walensky doi:10.1038/nchembio.1177 PUMA is a BCL-2 family protein that transmits stress signals to promote apoptosis. Upon DNA damage, a unique binding determinant within PUMA triggers partial unfolding of BCL-XL, resulting in the release of sequestered p53 and commitment to p53-dependent cell death. See also: Article by Follis et al. Metalloenzymes: Cage redesign explains assembly   pp143 - 144 Elizabeth C Theil and Paola Turano doi:10.1038/nchembio.1182 Control of protein self-assembly and disassembly, which is central to metabolism and engineering applications, remains challenging. Here, a perspicacious redesign of interfaces in the multisubunit ferritin protein cage provides single, modifiable subunits that assemble with Cu2+ templating and give insights into the cage assembly code. See also: Article by Huard et al. Chemical Biology JOBS of the week Computational Biologist Gene Center Munich, Ludwig Maximilians-University Munich Postdoc in Zebrafish Liver Development and Disease Cincinnati Children's Hospital Research Foundation 2 Bioinformaticians / Computational Biologists max planck institute PhD in Thermoelectric Materials University of Santiago de Compostela, Spain Research Fellow – Computational Biophysics and Bioengineering RMIT University More Science jobs from Chemical Biology EVENT 4th International Conference for Young Chemists (ICYC) 30 January-1 February, 2013 Penang, Malaysia More science events from Review Top Essential nontranslational functions of tRNA synthetases   pp145 - 153 Min Paul and Paul Schimmel doi:10.1038/nchembio.1158 Beyond their canonical functions of charging tRNAs with amino acids for protein translation, tRNA synthetases have numerous nontranslational roles that regulate signaling, immunity and development. Brief Communications Top A conserved asparagine has a structural role in ubiquitin-conjugating enzymes   pp154 - 156 Christopher E Berndsen, Reuven Wiener, Ian W Yu, Alison E Ringel and Cynthia Wolberger doi:10.1038/nchembio.1159 Ubiquitin-conjugating (E2) enzymes contain a conserved asparagine that has been proposed to stabilize an oxyanion intermediate. Structural and biochemical studies of Ubc13 suggest that this residue has a structural role in stabilizing the E2 active site. The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry   pp157 - 159 Weixin Tang and Wilfred A van der Donk doi:10.1038/nchembio.1162 Heterologous expression of the two components of enterococcal cytolysin with a lanthionine synthetase enables the structural determination of this antimicrobial and hemolytic pair, revealing unexpected stereochemistry in one of the lanthionine bridges that is driven by peptide sequence. An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor   pp160 - 162 Keiichi Yoshikawa, Hiroaki Nakagawa, Naoki Mori, Hidenori Watanabe and Kazushige Touhara doi:10.1038/nchembio.1164 A natural aliphatic alcohol ligand of the mouse orphan odorant receptor Olfr288 from the male preputial gland is regulated by testosterone and affects attractiveness to female mice. Chemical compounds See also: News and Views by Luetje Articles Top PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis   pp163 - 168 Ariele Viacava Follis, Jerry E Chipuk, John C Fisher, Mi-Kyung Yun, Christy R Grace, Amanda Nourse, Katherine Baran, Li Ou, Lie Min, Stephen W White, Douglas R Green and Richard W Kriwacki doi:10.1038/nchembio.1166 π-stacking interactions unique between residues of PUMA and Bcl-xL, which lead to the unfolding of Bcl-xL via an allosteric mechanism, are required to disrupt p53–Bcl-xL interaction and induce apoptosis. This is the first example of regulated protein unfolding for signal transmission. See also: News and Views by Walensky Re-engineering protein interfaces yields copper-inducible ferritin cage assembly   pp169 - 176 Dustin J E Huard, Kathleen M Kane and F Akif Tezcan doi:10.1038/nchembio.1163 A new protein engineering approach inserts metal-coordination motifs to stabilize natural protein interfaces while other favorable contacts are removed, yielding metal-inducible protein-protein interactions that have allowed the study of a self-assembling protein cage and the chemical labeling of its interior. See also: News and Views by Theil & Turano A new structural paradigm in copper resistance in Streptococcus pneumoniae    pp177 - 183 Yue Fu, Ho-Ching Tiffany Tsui, Kevin E Bruce, Lok-To Sham, Khadine A Higgins, John P Lisher, Krystyna M Kazmierczak, Michael J Maroney, Charles E Dann III, Malcolm E Winkler and David P Giedroc doi:10.1038/nchembio.1168 Structural analyses reveal that CopA and CupA share a binuclear Cu(I) ion binding motif and that copper is trafficked from a low-affinity site on CupA to a high-affinity site in CopA, making CupA the first membrane-bound copper chaperone important in copper resistance. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain   pp184 - 191 Lindsey I James, Dalia Barsyte-Lovejoy, Nan Zhong, Liubov Krichevsky, Victoria K Korboukh, J Martin Herold, Christopher J MacNevin, Jacqueline L Norris, Cari A Sagum, Wolfram Tempel, Edyta Marcon, Hongbo Guo, Cen Gao, Xi-Ping Huang, Shili Duan, Andrew Emili, Jack F Greenblatt, Dmitri B Kireev, Jian Jin, William P Janzen, Peter J Brown, Mark T Bedford, Cheryl H Arrowsmith and Stephen V Frye doi:10.1038/nchembio.1157 Methylation of lysine residues regulates chromatin function in part by recruiting readers to these marks. UNC1215, a selective antagonist of the methyllysine reader L3MBTL3 with a polyvalent mode of interaction, reveals BCLAF1 as a methyllysine-dependent interaction partner for L3MBTL3. Chemical compounds Addendum Top Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury   p192 Alexei Degterev, Zhihong Huang, Michael Boyce, Yaqiao Li, Prakash Jagtap, Noboru Mizushima, Gregory D Cuny, Timothy J Mitchison, Michael A Moskowitz and Junying Yuan doi:10.1038/nchembio0313-192a Corrigendum Top Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7   p192 Yingnan Zhang, Lijuan Zhou, Lionel Rouge, Aaron H Phillips, Cynthia Lam, Peter Liu, Wendy Sandoval, Elizabeth Helgason, Jeremy M Murray, Ingrid E Wertz and Jacob E Corn doi:10.1038/nchembio0313-192b Top Advertisement Subscribe today to Nature Chemical Biology Reflecting the diversity and excitement of chemical biology research. Subscribe online here today: https://secure.nature.com/subscribe/nchembio   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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