Molecular Systems Biology - New articles published 5 February 2013

Latest Articles 5th Feb 2013   Featured Article Research Article   Web feeds About Open access   Advertisement Molecular Systems Biology - New Review Series This series features Reviews on the technological platforms and methodologies that are driving systems and synthetic biology forward to reach new frontiers in biology. Read free content at www.nature.com/msb/focus   Featured Article Evolutionary potential, cross-stress behavior and the genetic basis of acquired stress resistance in Escherichia coli Escherichia coli cells were evolved over 500 generations and profiled in four abiotic stressors to observe several cases of emerging cross-stress behavior whereby adaptation to one stressful environment provided fitness advantage when exposed to a second stressor. Martin Dragosits, Vadim Mozhayskiy, Semarhy Quinones-Soto, Jiyeon Park & Ilias Tagkopoulos Molecular Systems Biology 9:643; doi:10.1038/msb.2012.76; published 5 February 2013 Full Text | PDF | Supp. Inf. | Review Process Research Article Properties of cell death models calibrated and compared using Bayesian approaches A Bayesian framework is used to calibrate a mass-action model of receptor-mediated apoptosis. Despite parameter non-identifiability and model ‘sloppiness’, Bayes factor analysis discriminates between two alternative models of mitochondrial outer membrane permeabilization. Hoda Eydgahi, William W Chen, Jeremy L Muhlich, Dennis Vitkup, John N Tsitsiklis & Peter K Sorger Molecular Systems Biology 9:644; doi:10.1038/msb.2012.69; published 5 February 2013 Full Text | PDF | Supp. Inf. | Review Process

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