Tuesday, January 8, 2013

Molecular Systems Biology - New articles published 8 January 2013

Molecular Systems Biology
 
Latest Articles 8th Jan 2013
 
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Featured Article

Deconvolving the roles of Wnt ligands and receptors in sensing and amplification

Establishment of cell polarity involves sensing of external cues followed by signal amplification. Analysis of Caenorhabditis elegans P-cell polarity in Wnt ligand and receptor mutants is used to separate the contribution of ligands and receptors to the sensing and amplification processes.

Rui Zhen Tan, Ni Ji, Remco A Mentink, Hendrik C Korswagen & Alexander van Oudenaarden

Molecular Systems Biology 9:631; doi:10.1038/msb.2012.64; published 8 January 2013

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Research Article

An Oct4-Sall4-Nanog network controls developmental progression in the pre-implantation mouse embryo

Coordination of many biological processes is necessary for mammalian pre-implantation embryo development. The underlying regulatory network was mapped through mathematical modeling, gene-specific knockdowns, and profiling of pooled embryos, single embryos, and single cells.

Meng How Tan, Kin Fai Au, Denise E Leong, Kira Foygel, Wing H Wong & Mylene WM Yao

Molecular Systems Biology 9:632; doi:10.1038/msb.2012.65; published 8 January 2013

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