EMBO Reports - Table of Contents alert Volume 14 Issue 1, pp 1-102

TABLE OF CONTENTS January 2013 | Volume 14, Issue 1 Upfront Science & Society Review Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Please take a look at these papers that recently appeared in EMBO reports: microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein Benjamin D Pinder & Craig A Smibert Defining a new role of GW182 in maintaining miRNA stability Bing Yao, Lan B La, Ying-Chi Chen, Lung-Ji Chang & Edward K L Chan Regulation of mammalian cell differentiation by long non-coding RNAs Wenqian Hu, Juan R Alvarez-Dominguez & Harvey F Lodish   Upfront Top Editorial Rise of the planet Despite early failures, somatic gene therapy has recently shown renewed promise. Howy suggests that the day may come when germline gene therapy needs also to be reconsidered. Howy Jacobs EMBO reports (2013), 14, 1; 10.1038/embor.2012.194 Full text | PDF Published online: 03 January 2013 Subject Categories: Health & Disease | Societal Issues & Politics Opinion Aiming high, but investing little The French government has ambitious goals to make France a leading nation for synthetic biology research, but it still needs to put its money where its mouth is and provide the field with dedicated funding and other support. Morgan Meyer EMBO reports (2013), 14, 2; 10.1038/embor.2012.190 Full text | PDF Published online: 23 November 2012 Subject Categories: Science Policy & Funding Design for controllability The safety of genetically modified crops remains a contested issue, given the potential risk for human health and the environment. To further reduce any risks and alleviate public concerns, terminator technology could be used both to tag and control genetically modified plants. Hirokazu Tsukaya EMBO reports (2013), 14, 3; 10.1038/embor.2012.202 Full text | PDF Published online: 11 December 2012 Subject Categories: Genetically Modified Organisms Cellular promiscuity: explaining cellular fidelity in vivo against unrestrained pluripotency in vitro The differentiation of pluripotent stem cells into various progeny is perplexing. In vivo, nature imposes strict fate constraints. In vitro, PSCs differentiate into almost any phenotype. Might the concept of ‘cellular promiscuity’ explain these surprising behaviours? Gerald Schatten EMBO reports (2013), 14, 4; 10.1038/embor.2012.198 Full text | PDF Published online: 11 December 2012 Subject Categories: Development | Differentiation & Death | Genome Stability & Dynamics Hot off the Press Chaperoning the synapse—NMNAT protects Bruchpilot from crashing Maintaining active zone structure is crucial for synaptic function. In this issue of EMBO reports, NMNAT is shown to act as a chaperone that protects the active zone structural protein Bruchpilot from degradation. Elsa Lauwers and Patrik Verstreken EMBO reports (2013), 14, 5 - 6; 10.1038/embor.2012.193 Full text | PDF Published online: 30 November 2012 Subject Categories: Neuroscience Meeting Point EBEC 2012—An energetic time in Freiburg The ‘European Bioenergetics Conference’ (EBEC) took place in September 2012. The conference is a bi-annual event that brings together researchers from across the globe to discuss progress in this diverse and challenging field. Paolo Bernardi and Valentina Giorgio EMBO reports (2013), 14, 7 - 9; 10.1038/embor.2012.200 Full text | PDF Published online: 11 December 2012 Subject Categories: Cellular Metabolism Correspondence Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin Viola H Lobert, Jarle Bruun, Hilde Abrahamsen, Ragnhild A Lothe, Harald Stenmark, Matthias Kolberg and Coen Campsteijn EMBO reports (2013), 14, 10 - 11; 10.1038/embor.2012.188 Full text | PDF Published online: 11 December 2012 Subject Categories: Signal Transduction | Molecular Biology of Disease | Proteins Science & Society Top The biochemistry of love: an oxytocin hypothesis The old saying that ‘love heals’ has some truth to it. The intricate dance between two neuropeptides both regulates our ability to love and influences our health and well-being. C Sue Carter and Stephen W Porges EMBO reports (2013), 14, 12 - 16; 10.1038/embor.2012.191 Full text | PDF Published online: 27 November 2012 Subject Categories: Evolution, Environment & Agriculture | Health & Disease The promise and perils of Antarctic fishes The waters around the Antarctic are a treasure trove of fauna specially adapted to extreme cold temperatures. However, as with many other marine ecosystems, its life forms are threatened by human actions. Kristin M O'Brien and Elizabeth L Crockett EMBO reports (2013), 14, 17 - 24; 10.1038/embor.2012.203 Full text | PDF Published online: 11 December 2012 Subject Categories: Evolution, Environment & Agriculture | Societal Issues & Politics Protecting society Concerns over biosecurity remain unresolved, as the debate around the recent publications on human transmissible H5N1 flu demonstrated. A range of measures and the involvement of all stakeholders are needed to better protect society from malicious abuse of biological research. Christine Uhlenhaut, Reinhard Burger and Lars Schaade EMBO reports (2013), 14, 25 - 30; 10.1038/embor.2012.195 Full text | PDF Published online: 11 December 2012 Subject Categories: Science Infrastructures & Publishing | Science Policy & Funding Tackling animal diseases to protect human health Veterinary research is gaining in importance not only because of the economic impact of animal diseases, but also because animals are a fertile reservoir of zoonoses; pathogens that could jump the species barrier and infect humans. Andrea Rinaldi EMBO reports (2013), 14, 31 - 35; 10.1038/embor.2012.201 Full text | PDF Published online: 11 December 2012 Subject Categories: Evolution, Environment & Agriculture | Health & Disease Caught in the act Femtobiology freeze-frames crucial split seconds of chemical reactions to investigate how enzymes function. The potential prize from this knowledge could be new avenues for drug development or ways to produce clean energy. Philip Hunter EMBO reports (2013), 14, 36 - 38; 10.1038/embor.2012.199 Full text | PDF Published online: 11 December 2012 Subject Categories: Technology, Development & Applications Review Top A matter of life and death: self-renewal in stem cells When stem cells divide they can either self-renew to maintain the pool of undifferentiated cells or they can differentiate into specialized cell lineages. This review discusses current concepts and mechanisms of adult stem cell self-renewal. Elaine Fuchs and Ting Chen EMBO reports (2013), 14, 39 - 48; 10.1038/embor.2012.197 Abstract | Full text | PDF Published online: 11 December 2012 Subject Categories: Differentiation & Death Scientific Reports Top Structural basis of ligand recognition in 5-HT3 receptors The crystal structures of a binding protein engineered to recognize serotonin (5-HT) and the anti-emetic granisetron with affinities comparable to the 5-HT3 receptor reveal important structural details of ligand recognition in the 5-HT3 receptor. Divya Kesters, Andrew J Thompson, Marijke Brams, René van Elk, Radovan Spurny, Matthis Geitmann, Jose M Villalgordo, Albert Guskov, U Helena Danielson, Sarah C R Lummis, August B Smit and Chris Ulens EMBO reports (2013), 14, 49 - 56; 10.1038/embor.2012.189 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 November 2012 Subject Categories: Membranes & Transport | Neuroscience | Structural Biology Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration This study reports that stimulation of cells with FGF1 promotes PtdIns5P production and demonstrates that a PtdIns5P-producing loop constituted by PI3KIII, PIKfyve and MTMR3 is required for cell migration. Angela Oppelt, Viola H Lobert, Kaisa Haglund, Ashley M Mackey, Lucia E Rameh, Knut Liestøl, Kay Oliver Schink, Nina Marie Pedersen, Eva M Wenzel, Ellen M Haugsten, Andreas Brech, Tor Erik Rusten, Harald Stenmark and Jørgen Wesche EMBO reports (2013), 14, 57 - 64; 10.1038/embor.2012.183 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 November 2012 Subject Categories: Membranes & Transport Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila This report shows that oncoprotein Src activates Yki via inactivation of the Hippo pathway and simultaneous activation of JNK, which antagonizes Yki cell-autonomously causing propagation of Yki activity to neighbouring cells and inducing overgrowth of surrounding tissue. Masato Enomoto and Tatsushi Igaki EMBO reports (2013), 14, 65 - 72; 10.1038/embor.2012.185 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 November 2012 Subject Categories: Signal Transduction | Molecular Biology of Disease Silencing of proviruses in embryonic cells: efficiency, stability and chromatin modifications This study describes the mode in which embryonic stem cells block retroviral infection through transcriptional silencing of proviral DNAs: by a highly efficient mechanism targeting the tRNA primer binding site (PBS) or by less efficient ones that are PBS-independent. Sharon Schlesinger and Stephen P Goff EMBO reports (2013), 14, 73 - 79; 10.1038/embor.2012.182 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 November 2012 Subject Categories: Chromatin & Transcription | Microbiology & Pathogens microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein Argonaute 1 directly interacts with the RNA binding protein Smaug in Drosophila, is thereby recruited to the Smaug target nanos mRNA and is required for Smaug-mediated translational repression of the nanos mRNA. Benjamin D Pinder and Craig A Smibert EMBO reports (2013), 14, 80 - 86; 10.1038/embor.2012.192 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 November 2012 Subject Categories: RNA Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot Nicotinamide mononucleotide adenylyltransferase (NMNAT) is shown to be a synapse maintenance factor that protects the active zone structure by interacting with the active zone protein Bruchpilot and shielding it from activity-induced degradation in Drosophila. Shaoyun Zang, Yousuf O Ali, Kai Ruan and R Grace Zhai EMBO reports (2013), 14, 87 - 94; 10.1038/embor.2012.181 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 November 2012 Subject Categories: Proteins | Neuroscience A Salmonella Typhi homologue of bacteriophage muramidases controls typhoid toxin secretion A fundamental factor for many pathogens is the ability to secrete proteins to the outside. This study identifies a new mechanism of protein secretion used by the bacterial pathogen Salmonella Typhi to secrete Typhoid toxin, an essential virulence factor. Hélène Hodak and Jorge E Galán EMBO reports (2013), 14, 95 - 102; 10.1038/embor.2012.186 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 November 2012 Subject Categories: Microbiology & Pathogens Advertisement EMBO - Transparency in Scientific Publishing EMBO reports has a fair and transparent process to rapidly publish your best science. Transparent - No confidential referee remarks - Published referee reports - Detailed decisions - Source Data published alongside figures Fair - Scooping protection - Pre-decision cross-referee commenting - Fixed bar for revisions - Fast process   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2011 European Molecular Biology Organization