TABLE OF CONTENTS
| 31 October 2012 | Volume 31, Issue 21 |  | | |  |  Have you seen?
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****** |  | |  | | Advertisement | | | | | | Have you seen? | Top | |  | | Close encounter: mitochondria, endoplasmic reticulum and Alzheimer’s disease Alzheimer’s disease (AD) pathogenesis is linked to loss of presenilins, components of γ-secretase. Presenilins are located at MAM, a membrane domain at the interface of mitochondria and endoplasmic reticulum (ER). Presenilin loss alters ER–mitochondrial communication, linking it to AD pathogenesis. Bart De Strooper and Luca Scorrano The EMBO Journal (2012), 31, 4095 - 4097; 10.1038/emboj.2012.279 Abstract | Full text | PDF | Related article Published online: 09 October 2012 | | | | Runx1: no longer just for leukemia The combination of lineage-tracing and experimental carcinogenesis establishes a crucial role of the leukaemic transcription factor Runx1 also for epithelial tumorigenesis. Ichiro Taniuchi, Motomi Osato and Yoshiaki Ito The EMBO Journal (2012), 31, 4098 - 4099; 10.1038/emboj.2012.282 Abstract | Full text | PDF | Related article Published online: 12 October 2012 | | | | Microtubule dynamics and signal transduction at the immunological synapse: new partners and new connections Antigen recognition induces T-cell polarization towards antigen presenting cells, generating the immunological synapse at the cell interface. Now, microtubule-mediated polarized vesicle transport is shown to be required for the organization of a signalling-competent synapse and hence T-cell activation. Rémi Lasserre and Andrés Alcover The EMBO Journal (2012), 31, 4100 - 4102; 10.1038/emboj.2012.276 Abstract | Full text | PDF | Related article Published online: 09 October 2012 | | | | Sprouting a new take on stem cell aging Studying stem cell/niche interactions at the molecular level reveals age-dependent niche signals as direct determinants of muscle stem cell quiescence. Joseph T Rodgers and Thomas A Rando The EMBO Journal (2012), 31, 4103 - 4105; 10.1038/emboj.2012.281 Abstract | Full text | PDF | Related article Published online: 05 October 2012 | | Articles | Top | | | | Upregulated function of mitochondria-associated ER membranes in Alzheimer disease Alzheimer disease (AD) associated (gamma)-secretase components presenilin-1 and -2 accumulate in MAM, an LR-like ER subcompartment connected to mitochondria. MAM function increases in patients with familial or sporadic AD and may be linked to AD pathogenesis. Estela Area-Gomez, Maria del Carmen Lara Castillo, Marc D Tambini, Cristina Guardia-Laguarta, Ad J C de Groof, Moneek Madra, Junichi Ikenouchi, Masato Umeda, Thomas D Bird, Stephen L Sturley and Eric A Schon The EMBO Journal (2012), 31, 4106 - 4123; 10.1038/emboj.2012.202 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 August 2012 | | | | Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer Insights into the regulation of cancer and tissue stem cells during tumour onset are important for therapies. This report on the leukaemic factor Runx1 as crucial contributor to various epithelial cancers offers an alternative therapeutic perspective. Cornelia Johanna Franziska Scheitz, Tae Seung Lee, David James McDermitt and Tudorita Tumbar The EMBO Journal (2012), 31, 4124 - 4139; 10.1038/emboj.2012.270 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 02 October 2012 | | | | End-binding protein 1 controls signal propagation from the T cell receptor Microtubule growth governed by plus-end binding protein EB1 is needed at the immunological synapse to promote the encounter of T cell receptor containing vesicles with signalling ones, which facilitates signal transduction during T cell activation. Noa B Martín-Cófreces, Francesc Baixauli, María J López, Diana Gil, Alicia Monjas, Balbino Alarcón and Francisco Sánchez-Madrid The EMBO Journal (2012), 31, 4140 - 4152; 10.1038/emboj.2012.242 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 24 August 2012 | | | | RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids Listeria monocytogenes secretes bacterial nucleic acids into the cytoplasm of infected cells that are recognized by the RIG-I pathway to trigger Interferon β production and inflammasome activation. Zeinab Abdullah, Martin Schlee, Susanne Roth, Mobarak Abu Mraheil, Winfried Barchet, Jan Böttcher, Torsten Hain, Sergej Geiger, Yoshihiro Hayakawa, Jörg H Fritz, Filiz Civril, Karl-Peter Hopfner, Christian Kurts, Jürgen Ruland, Gunther Hartmann, Trinad Chakraborty and Percy A Knolle The EMBO Journal (2012), 31, 4153 - 4164; 10.1038/emboj.2012.274 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 October 2012 | | | | A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection ChIP-seq analyses reveal a common subtelomeric CTCF- and cohesion-binding site important for RNA polymerase recruitment and TERRA transcription. Zhong Deng, Zhuo Wang, Nick Stong, Robert Plasschaert, Aliah Moczan, Horng-Shen Chen, Sufeng Hu, Priyankara Wikramasinghe, Ramana V Davuluri, Marisa S Bartolomei, Harold Riethman and Paul M Lieberman The EMBO Journal (2012), 31, 4165 - 4178; 10.1038/emboj.2012.266 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 25 September 2012 | | | | Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation HeLa cell clones selected for survival under continuous inhibition of kinesin-5/Eg5 reveal a redundant novel mechanism for centrosome separation. Jonne A Raaijmakers, Roy G H P van Heesbeen, Johnathan L Meaders, Erica F Geers, Belen Fernandez-Garcia, René H Medema and Marvin E Tanenbaum The EMBO Journal (2012), 31, 4179 - 4190; 10.1038/emboj.2012.272 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 02 October 2012 | | | | The exomer cargo adaptor structure reveals a novel GTPase-binding domain The first crystal structure of the exomer cargo adaptor complex, which mediates trafficking from the trans-Golgi network to the plasma membrane, uncovers a novel FN3–BRCT domain required for Arf1 GTPase-dependent membrane recruitment of exomer. Jon E Paczkowski, Brian C Richardson, Amanda M Strassner and J Christopher Fromme The EMBO Journal (2012), 31, 4191 - 4203; 10.1038/emboj.2012.268 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 September 2012 | | | | Endocytic tubules regulated by Rab GTPases 5 and 11 are used for envelopment of herpes simplex virus HSV capsids are enveloped by tubular membranes of early/recycling endosomal origin under the control of Rab5 and Rab11, rather than membranes derived from the trans-Golgi network. Michael Hollinshead, Helen L Johns, Charlotte L Sayers, Claudia Gonzalez-Lopez, Geoffrey L Smith and Gillian Elliott The EMBO Journal (2012), 31, 4204 - 4220; 10.1038/emboj.2012.262 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 September 2012 | | | | Metazoan Hsp70 machines use Hsp110 to power protein disaggregation Aggregation of misfolded proteins disrupts cellular homeostasis leading to ageing and disease. In metazoa, the nucleotide exchange factor Hsp110 acts together with the human Hsp70-Hsp40 chaperone system to promote protein disaggregation and longevity. Heike Rampelt, Janine Kirstein-Miles, Nadinath B Nillegoda, Kang Chi, Sebastian R Scholz, Richard I Morimoto and Bernd Bukau The EMBO Journal (2012), 31, 4221 - 4235; 10.1038/emboj.2012.264 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 September 2012 | | | | Translational repression precedes and is required for ZAP-mediated mRNA decay The antiviral protein ZAP is known to degrade viral mRNAs; ZAP also represses translational initiation of target mRNAs by disrupting the interaction between eIF4G and eIF4A. Yiping Zhu, Xinlu Wang, Stephen P Goff and Guangxia Gao The EMBO Journal (2012), 31, 4236 - 4246; 10.1038/emboj.2012.271 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 28 September 2012 | | Addendum | Top | | | | Highly diverse TCRα chain repertoire of pre-immune CD8+ T cells reveals new insights in gene recombination Raphael Genolet, Brian J Stevenson, Laurent Farinelli, Magne Østerås and Immanuel F Luescher The EMBO Journal (2012), 31, 4247 - 4248; 10.1038/emboj.2012.277 Full text | PDF Published online: 31 October 2012 | | | | Advertisement | | | | | | Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. 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