TABLE OF CONTENTS
| November 2012 | Volume 13, Issue 11 |  | | |  |  Upfront
 Science & Society
 Reviews
 Scientific Reports
Also new
 AOP | | | | ******
The publication of this issue was delayed due to Hurricane Sandy closing Nature Publishing Group’s New York offices temporarily. We apologize for any inconvenience caused.
****** | | | Upfront | Top | | | | Editorial | |  | | Log cabins and lab coats The case for science in the US is getting drowned out by other voices, notably on the right. Howy argues that to combat this worrying trend, scientists need to re-engage politically in the Republican Party. Howy Jacobs EMBO reports (2012), 13, 941; 10.1038/embor.2012.148 Full text | PDF Published online: 06 November 2012 Subject Categories: Societal Issues & Politics | | | | Opinion | | | | Not too much and not too little We tend to think in black and white terms of good versus bad alleles and their meaning for disease. However, in doing so, we ignore the potential importance of heterozygous alleles. Paul van Helden EMBO reports (2012), 13, 942; 10.1038/embor.2012.153 Full text | PDF Published online: 12 October 2012 Subject Categories: Health & Disease | | | | Hot off the Press | | | | Through thick and thin: the conundrum of chromatin fibre folding in vivo The established view that chromatin is compacted into 30 nm fibres in the nucleus is being challenged. One of these studies is published in this issue of EMBO reports and shows that chromatin predominantly organizes as 10 nm fibres in somatic mouse cells. These recent data and their implications are discussed here. Delphine Quénet, James G McNally and Yamini Dalal EMBO reports (2012), 13, 943 - 944; 10.1038/embor.2012.143 Full text | PDF Published online: 05 October 2012 Subject Categories: Chromatin & Transcription | | | | Meeting Point | | | | The flies of Icarus: science with wings in Crete The eighteenth EMBO Conference on ‘The Molecular and Developmental Biology of Drosophila’ took place in Crete in June 2012. The talks highlighted the synergy of combining methods, approaches and disciplines in this increasingly versatile model system. Irene Miguel-Aliaga, Brian Oliver and Aurelio A Teleman EMBO reports (2012), 13, 945 - 947; 10.1038/embor.2012.154 Full text | PDF Published online: 12 October 2012 Subject Categories: Development | Cell & Tissue Architecture | Genomic & Computational Biology | | Science & Society | Top | | | | The HIV epidemic among men who have sex with men—behaviour beats science More than three decades after the emergence of HIV/AIDS, more than 30 million people worldwide still live with the disease. In the West, those most at risk are men who have sex with men owing to a combination of social factors and, ironically, improved healthcare. Zohar Mor and Michael Dan EMBO reports (2012), 13, 948 - 953; 10.1038/embor.2012.152 Full text | PDF Published online: 16 October 2012 Subject Categories: Health & Disease | Societal Issues & Politics | | | | Science and rock An innovative partnership between a research institute and a music festival is helping to connect scientists and young people in Portugal. It is also bringing in money to fund research. Maria João Leão and Sílvia Castro EMBO reports (2012), 13, 954 - 958; 10.1038/embor.2012.151 Full text | PDF Published online: 12 October 2012 Subject Categories: Science Policy & Funding | Societal Issues & Politics | Scientific Training & Careers | | | | Explaining life There are many different explanations of life inspired by scientific knowledge, philosophical theories or religious beliefs. Synthetic biologists would do well to take these views into account when they work to create artificial organisms and attempt to answer the question: what is life? Anna Deplazes-Zemp and Nikola Biller-Andorno EMBO reports (2012), 13, 959 - 963; 10.1038/embor.2012.150 Full text | PDF Published online: 12 October 2012 Subject Categories: Genetically Modified Organisms | Philosophy & History of Science | | | | Nothing but the truth Many scientists blame the media for sensationalising scientific findings, but new research suggests that things can go awry at all levels, from the scientific report to the press officer to the journalist. Paige Brown EMBO reports (2012), 13, 964 - 967; 10.1038/embor.2012.147 Full text | PDF Published online: 12 October 2012 Subject Categories: Science Infrastructures & Publishing | Scientific Training & Careers | Societal Issues & Politics | | | | The inflammation theory of disease An increasing body of evidence shows that chronic inflammation causes and advances many common diseases. This opens new possibilities for treatment and therapy by blocking the inflammatory processes. Philip Hunter EMBO reports (2012), 13, 968 - 970; 10.1038/embor.2012.142 Full text | PDF Published online: 09 October 2012 Subject Categories: Health & Disease | | Reviews | Top | | | | Regulation of mammalian cell differentiation by long non-coding RNAs Many long non-coding RNAs (lncRNAs) are expressed in mammalian cells but their function is not well understood. This review discusses specific examples of lncRNAs that play a role in cell fate decisions/cellular differentiation and synthesizes emerging principles of lncRNA function. Wenqian Hu, Juan R Alvarez-Dominguez and Harvey F Lodish EMBO reports (2012), 13, 971 - 983; 10.1038/embor.2012.145 Abstract | Full text | PDF Published online: 16 October 2012 Subject Categories: RNA | Development | Differentiation & Death | | | | Fellow travellers: emergent properties of collective cell migration Collective cell migration occurs during embryonic development and cancer invasion. Recent insight into key features of collective cell migration and the importance of these for directional movement, as well as common strategies of collective movement, are highlighted in this review. Pernille Rørth EMBO reports (2012), 13, 984 - 991; 10.1038/embor.2012.149 Abstract | Full text | PDF Published online: 12 October 2012 Subject Categories: Cell & Tissue Architecture | | Scientific Reports | Top | | | | Open and closed domains in the mouse genome are configured as 10-nm chromatin fibres Electron spectroscopic tomography imaging of mouse cells reveals that both open and closed chromatin domains are composed of 10nm chromatin fibers, indicating that chromatin organization into 30nm fibers may not occur in vivo. Eden Fussner, Mike Strauss, Ugljesa Djuric, Ren Li, Kashif Ahmed, Michael Hart, James Ellis and David P Bazett-Jones EMBO reports (2012), 13, 992 - 996; 10.1038/embor.2012.139 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 September 2012 Subject Categories: Chromatin & Transcription | | | | Chd1 chromatin remodelers maintain nucleosome organization and repress cryptic transcription Schizosaccharomyces pombe Chd1 chromatin remodellers, Hrp1 and Hrp3, are shown to be required for correct positioning of nucleosomes in gene-coding regions and for genome-wide repression of cryptic transcripts. The study also indicates that multiple mechanisms prevent cryptic promoter activity. Bianca P Hennig, Katja Bendrin, Yang Zhou and Tamás Fischer EMBO reports (2012), 13, 997 - 1003; 10.1038/embor.2012.146 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 02 October 2012 Subject Categories: Chromatin & Transcription | | | | CKIP-1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of proteasome to promote substrate degradation This report reveals an unexpected adaptor role for CKIP-1 in coupling the ubiquitin ligase Smurf1 and the Rpt6 ATPase of the proteasome, thus mediating the delivery of ubiquitinated substrates to the proteasome. Yifang Wang, Jing Nie, Yiwu Wang, Luo Zhang, Kefeng Lu, Guichun Xing, Ping Xie, Fuchu He and Lingqiang Zhang EMBO reports (2012), 13, 1004 - 1011; 10.1038/embor.2012.144 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 02 October 2012 Subject Categories: Proteins | | | | Hairless promotes PPARγ expression and is required for white adipogenesis The transcriptional co-factor hairless, known to be important for hair growth, stimulates PPARgamma expression and is essential for white adipogenesis in vivo. Susann Kumpf, Michael Mihlan, Alexander Goginashvili, Gerald Grandl, Helmuth Gehart, Aurélie Godel, Juliane Schmidt, Julius Müller, Marco Bezzi, Arne Ittner, Ernesto Guccione, Christian Wolfrum and Romeo Ricci EMBO reports (2012), 13, 1012 - 1020; 10.1038/embor.2012.133 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 September 2012 Subject Categories: Cellular Metabolism | Differentiation & Death | Chromatin & Transcription | | | | Calcium tips the balance: a microtubule plus end to lattice binding switch operates in the carboxyl terminus of BPAG1n4 This study reports a rapid, calcium-regulated, EF-hand-dependent switch between microtubule plus end and lattice binding in the C-terminus of the spectraplakin BPAG1n4, indicating that calcium can regulate the dynamic interaction between microtubules and their regulatory proteins. Mridu Kapur, Wei Wang, Michael T Maloney, Ivan Millan, Victor F Lundin, Thuy-An Tran and Yanmin Yang EMBO reports (2012), 13, 1021 - 1029; 10.1038/embor.2012.140 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 September 2012 Subject Categories: Cell & Tissue Architecture | Signal Transduction | Proteins | | Corrections | Top | | | | Erratum | | | | Mitotic spindle orientation can direct cell fate and bias Notch activity in chick neural tube Raman M Das and Kate G Storey EMBO reports (2012), 13, 1030; 10.1038/embor.2012.159 Full text | PDF Published online: 12 October 2012 | | | | |  | | Advertisement | | | | | | Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2011 European Molecular Biology Organization |  | | | | |
No comments:
Post a Comment