Nature Reviews Microbiology contents December 2012 Volume 10 Number 12 pp 799-876

TABLE OF CONTENTS
December 2012 Volume 10 Number 12
Impact Factor 21.182 *	In this issue Editorial Research Highlights News and Analysis Progress Reviews Perspectives Also this month Article Series: Vector-borne diseases  Featured article: Animal models for HIV/AIDS research Theodora Hatziioannou1 & David T. Evans
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EDITORIAL		Top
Redaction, retraction and reaction p799 | doi:10.1038/nrmicro2928 In our final Editorial of the year, we take a look back at 2012 and the microbiology-related research that made the news. Full Text | PDF
RESEARCH HIGHLIGHTS Top Bacterial secretion: Sec and Tat collaborate in a Rieske business p801 | doi:10.1038/nrmicro2912 Characterization of a bacterial cytoplasmic membrane protein that requires the action of both the Sec and Tat pathways to ensure correct insertion into the membrane. PDF Bacterial physiology: Caulobacter chooses to self-destruct p802 | doi:10.1038/nrmicro2913 The identification of a novel endonuclease in C. crescentus that cleaves chromosomal DNA in response to DNA damage, providing support for the hypothesis that bacteria undergo apoptosis-like cell death. PDF Environmental microbiology: Bacterial power lines p802 | doi:10.1038/nrmicro2914 The identification of cable-like filamentous bacteria that support the long-distance transport of electrons in anoxic sediments. PDF Virology: Giant viruses — movers and shakers p803 | doi:10.1038/nrmicro2927 Didier Raoult, Eugene Koonin and colleagues now provide more details about the complement of mobile genetic elements associated with giant viruses. PDF Phage biology: Phage plays copycat with ToxIN p804 | doi:10.1038/nrmicro2920 A newly discovered lytic phage of the phytopathogen Pectobacterium atrosepticum suppresses toxin-mediated abortive infection by mimicking or hijacking the corresponding RNA antitoxin. PDF Immunology: Splice-tailored to fit the bug p804 | doi:10.1038/nrmicro2922 Alternative splicing of a hypervariable pattern recognition receptor confers pathogen specificity in insects. PDF IN THE NEWS Bacteriotherapy triumphs p804 | doi:10.1038/nrmicro2923 PDF Viral pathogenesis: SIV gives the virome a boost p805 | doi:10.1038/nrmicro2919 Pathogenic SIV infection is associated with expansion of the enteric virome. PDF IN BRIEF Techniques & applications: Shedding light on peptidoglycan growth | Microbiome: Sequencing saliva | Environmental microbiology: Ribosomal origin for polytheonamides PDF Microbiology JOBS of the week Lectureships in Molecular Microbiology Imperial College London Postdoctoral Associate In The Field Of Plant Biology And Microbiology Stony Brook University - Department of Biochemistry and Cell Biology Assistant professors in Environmental Microbiology; and Plant Biology / Phycology The American University of Beirut Faculty Position Microbiology University of Connecticut, Department of Molecular and Cell Biology Head 5-year Groups in the Institut Pasteur in Microbiology and Virology Institut Pasteur More Science jobs from Microbiology EVENT International Conference on Clinical Microbiology & Microbial Genomics 12.-14.11.12 US More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH The industrial evolution Susannah J. Salter p806 | doi:10.1038/nrmicro2915 This month's Genome Watch highlights new insights into the use of bacteria in industrial processes such as electricity generation and bioremediation. PDF
PROGRESS		Top
Structural vaccinology starts to deliver Philip R. Dormitzer, Guido Grandi & Rino Rappuoli p807 | doi:10.1038/nrmicro2893 The throughput of protein structure determination has increased greatly over the past decade, thanks to advances in X-ray crystallography and NMR spectroscopy. Protein structure information is now routinely used in vaccine design, and here, Rappuoli and colleagues describe some of the most recent developments in this new field of structural vaccinology. Abstract | Full Text | PDF
REVIEWS		Top
Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses Spencer V. Nyholm & Joerg Graf p815 | doi:10.1038/nrmicro2894 Invertebrates lack conventional antibody-based immunity but have the capacity to distinguish between symbionts and pathogens. In this Review, Nyholm and Graf describe how the innate immune system of four model invertebrates functions in the establishment and maintenance of bacterial symbioses. Abstract | Full Text | PDF
Microbial life in the phyllosphere Julia A. Vorholt p828 | doi:10.1038/nrmicro2910 Compared with our understanding of the microbial ecology of the rhizosphere (the below-ground parts of plants), our understanding of the microbial ecology of the phyllosphere (the aerial parts of plants) has lagged behind, but this has begun to change in recent years. Here, Julia Vorholt reviews the latest research into the composition of microbial phyllosphere communities, the factors that drive this composition and the adaptation of these communities to the plant environment. Abstract | Full Text | PDF
Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective Anders Folkesson, Lars Jelsbak, Lei Yang, Helle Krogh Johansen, Oana Ciofu, Niels Høiby & Søren Molin p841 | doi:10.1038/nrmicro2907 Pseudomonas aeruginosa infection of the airways is a major cause of mortality and morbidity for patients with cystic fibrosis (CF). Here, Molin and colleagues discuss how P. aeruginosa infection evolves from a state of early, intermittent colonization to a state of chronic infection. Studying the in vivo adaptation of P. aeruginosa will enhance our understanding of bacterial evolution, and could also be important for the development of new therapeutic strategies for CF-associated and other chronic infections. Abstract | Full Text | PDF
Animal models for HIV/AIDS research Theodora Hatziioannou & David T. Evans p852 | doi:10.1038/nrmicro2911 Although it may never be possible for a single animal model to recapitulate all of the features of HIV-1 infection of humans, there have been great advances in the development of small-animal and non-human primate models, as well as in the development of recombinant challenge viruses. Here, the authors review the advantages and disadvantages of the different animal models of HIV/AIDS with respect to their use in the preclinical development of vaccines and antiretroviral therapies. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: Vector-borne diseases Rethinking vector immunology: the role of environmental temperature in shaping resistance Courtney C. Murdock, Krijn P. Paaijmans, Diana Cox-Foster, Andrew F. Read & Matthew B. Thomas p869 | doi:10.1038/nrmicro2900 It has recently emerged that environmental factors such as ambient temperature can strongly influence insect immunity and, thus, shape the outcome of host-parasite interactions. Here, Murdock, Thomas and colleagues argue that, to get more accurate insights into vector resistance, we need to incorporate temperature variation into studies. Abstract | Full Text | PDF | Supplementary information
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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