Nature Reviews Genetics Contents December 2012 Volume 13 Number 12 pp 825-890

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TABLE OF CONTENTS
December 2012 Volume 13 Number 12
Impact Factor 38.075 *	In this issue Research Highlights Reviews Also this month Article series: Computational tools Study designs Disease mechanisms  Featured article: Adaptive evolution: evaluating empirical support for theoretical predictions Carrie F. Olson-Manning, Maggie R. Wagner & Thomas Mitchell-Olds
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The Encyclopedia of DNA Elements 30 papers published simultaneously in Nature, Genome Research and Genome Biology. Access videos, Features and the collected research papers, and explore the thematic threads that run through them via the Nature ENCODE explorer or the NatureENCODE app. Produced with support from Illumina
RESEARCH HIGHLIGHTS Top Molecular evolution: New layers to recombination patterns p825 | doi:10.1038/nrg3368 PDF Disease genetics: Mitochondrial mutation mixtures p826 | doi:10.1038/nrg3371 PDF Gene regulation: Bivalency buffer makes pluripotency connections p826 | doi:10.1038/nrg3372 PDF Molecular evolution: Epistasis prevails p828 | doi:10.1038/nrg3369 PDF Gene expression: Dynamic omics responses p828 | doi:10.1038/nrg3370 PDF IN BRIEF Quantitative traits: Genetic variation contributing to mRNA decay | Complex disease: Inflammatory bowel disease genetic association | Epigenetics: DNA methylation discovered in nematodes | RNA: RNA catalytic networks | Evolution: Robustness and plasticity in network evolution | Epigenetics: Asymmetric histone distribution in stem cells | Complex disease: Family history versus SNPs for disease predictions | Genome evolution: Orderly gene diversification PDF Genetics JOBS of the week Tenure Track Position in Evolutionary Genetics Emory University Assistant / Associate Professor- Molecular Biology and Genetics Cornell University More Science jobs from Genetics EVENT Complex Disease Genetics for Clinicians 24.-25.01.13 Cambridge, UK More science events from
REVIEWS		Top
Article series: Computational tools Text-mining solutions for biomedical research: enabling integrative biology Dietrich Rebholz-Schuhmann, Anika Oellrich & Robert Hoehndorf p829 | doi:10.1038/nrg3337 Text mining — retrieving information from papers and databases — is increasingly used in data-rich fields such as genomics, systems biology and biomedical research. This Review discusses recent tools that can aid researchers and sets out the potential of enhancing integrative research using text mining. Abstract | Full Text | PDF
Article series: Study designs ChIP-seq and beyond: new and improved methodologies to detect and characterize protein-DNA interactions Terrence S. Furey p840 | doi:10.1038/nrg3306 This Review discusses recent improvements to ChIP-seq and a range of complementary techniques, such as DNaseI hypersensitivity mapping, for studying protein-DNA interactions. Functional characterization of protein binding can be improved by methods analysing chromatin conformation or allele-specific binding. Abstract | Full Text | PDF
Evolution of genetic and genomic features unique to the human lineage Majesta O'Bleness, Veronica B. Searles, Ajit Varki, Pascal Gagneux & James M. Sikela p853 | doi:10.1038/nrg3336 The growing availability of primate genome sequences has allowed an evaluation of the genetic and genomic changes that may have contributed to human-specific traits. This article focuses on these unique changes and the potential mechanisms by which they may have occurred. Abstract | Full Text | PDF
Adaptive evolution: evaluating empirical support for theoretical predictions Carrie F. Olson-Manning, Maggie R. Wagner & Thomas Mitchell-Olds p867 | doi:10.1038/nrg3322 The theoretical principles of adaptive evolution are being put to the test in a growing range of species and populations, particularly with new sequencing technologies and high-throughput experimental methods making headway in this area. Abstract | Full Text | PDF
Article series: Disease mechanisms Human mitochondrial DNA: roles of inherited and somatic mutations Eric A. Schon, Salvatore DiMauro & Michio Hirano p878 | doi:10.1038/nrg3275 This Review discusses the roles of mitochondrial DNA (mtDNA) mutations in human disease. In addition to many primary mitochondrial diseases, there is emerging — and sometimes controversial — evidence that mutations in mtDNA are involved in complex traits such as neurodegeneration, ageing and cancer. Abstract | Full Text | PDF
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Nature Reviews Genetics ARTICLE SERIES ON COMPUTATIONAL TOOLS Starting October 2012 The scale and complexity of genetic and genomic data are ever-expanding, requiring biologists to apply increasingly more sophisticated information technology in the analysis, interpretation and storage of these data. This series contains articles that focus on the application of these software tools in genetics and genomics. Follow the Article Series online: www.nature.com/nrg/series/computational
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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