Molecular Systems Biology - New articles published 20 November 2012

Latest Articles 20th November 2012   Featured Article Research Article News and Views Correspondence   Web feeds About Open access Advertisement Cancer Metabolism in Molecular Systems Biology The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells Kakajan Komurov, Prahlad T Ram and colleagues Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death Nicholas A Graham, Thomas G Graeber and colleagues Metabolic rewiring drives resistance to targeted cancer therapy Jason W Locasale Signaling for death: tyrosine phosphorylation in the response to glucose deprivation Bryan D Bryson and Forest M White   Featured Article PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells Network-based analysis of transcriptome dynamics during activation in two human T-cell subpopulations identifies key regulators, and reveals that PLAU plays a critical role in both human and murine regulatory T-cell function. Feng He, Hairong Chen, Michael Probst-Kepper, Robert Geffers, Serge Eifes, Antonio del Sol, Klaus Schughart, An-Ping Zeng & Rudi Balling Molecular Systems Biology 8:624; doi:10.1038/msb.2012.56; published 20 November 2012 Full Text | PDF | Supp. Inf. | Review Process Research Article Programming stress-induced altruistic death in engineered bacteria Altruistic death is shown to confer a population level advantage in engineered E. coli. Cost-benefit trade-offs are analyzed and altruistic death is shown to account for the 'Eagle effect', whereby bacteria appear to grow better in high antibiotics concentrations. Yu Tanouchi, Anand Pai, Nicolas E Buchler & Lingchong You Molecular Systems Biology 8:626; doi:10.1038/msb.2012.57; published 20 November 2012 Full Text | PDF | Supp. Inf. | Review Process News and Views Altruistic cell death and collective drug resistance Carlos Carmona-Fontaine & Joao B Xavier Molecular Systems Biology 8:627; doi:10.1038/msb.2012.60; published 20 November 2012 Full Text | PDF Correspondence dNdS does not show positive selection drives separation of polar-tropical SAR11 populations Haiwei Luo & Austin L Hughes Molecular Systems Biology 8:625; doi:10.1038/msb.2012.58; published 20 November 2012 Full Text | PDF | Supp. Inf.

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