Molecular Systems Biology - New articles published 13 November 2012

Latest Articles 13th November 2012   Featured Article Research Articles   Web feeds About Open access The publication of this issue was delayed due to Hurricane Sandy closing our New York offices temporarily. We apologize for any inconvenience caused.   Advertisement The Emerging Field of Optogenetics   Karl Deisseroth talks to Thomas Lemberger about the emerging field of optogenetics at The EMBO Meeting 2012. Karl Deisseroth is professor of bioengineering and of psychiatry & behavioural sciences at Standford University.  WATCH THE VIDEO INTERVIEW HERE!     Featured Article Regulation of yeast central metabolism by enzyme phosphorylation A strategy is presented that combines metabolic fluxes with targeted phosphoproteomics measurements to drive testable hypotheses for the functionality of post-translational regulation in S. cerevisiae central metabolism. Ana Paula Oliveira, Christina Ludwig, Paola Picotti, Maria Kogadeeva, Ruedi Aebersold & Uwe Sauer Molecular Systems Biology 8:623; doi:10.1038/msb.2012.55; published 13 November 2012 Full Text | PDF | Supp. Inf. | Review Process Research Articles Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast Ensemble modelling is used to study the yeast high osmolarity glycerol (HOG) pathway, a prototype for eukaryotic mitogen-activated kinase signalling systems. The best fit model provides new insights into the function of this system, some of which are then experimentally validated. Jörg Schaber, Rodrigo Baltanas, Alan Bush, Edda Klipp & Alejandro Colman-Lerner Molecular Systems Biology 8:622; doi:10.1038/msb.2012.53; published 13 November 2012 Full Text | PDF | Supp. Inf. | Review Process Competition between species can stabilize public-goods cooperation within a species Cooperative phenotypes are found to be favored in a yeast population grown in the presence of a bacterial species. The bacteria drive cooperation within yeast by competing for essential resources and by limiting the access of cheaters to the public goods produced by cooperating yeast cells. Hasan Celiker & Jeff Gore Molecular Systems Biology 8:621; doi:10.1038/msb.2012.54; published 13 November 2012 Full Text | PDF | Supp. Inf. | Review Process

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