The EMBO Journal - Table of Contents alert Volume 31 Issue 19

TABLE OF CONTENTS 03 October 2012 | Volume 31, Issue 19 Have you seen? Articles Corrigendum Also new AOP Advertisement Call for entries! Eppendorf Young Investigator Award 2013 Prize money: 15,000 Euro Apply now only Entry deadline: 15 January 2013 Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement The EMBO Journal Editor's selection: Non-coding RNA's in Disease and Development Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway FREE Guanglei Zhuang, Napoleone Ferrara and colleagues Regulation of human lung alveolar multipotent cells by a novel p38a MAPK/miR-17-92 axis EMBO Open Feride Oeztuerk-Winder, Juan-Jose Ventura and colleagues miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver FREE Koji Okamoto, Hitoshi Nakagama and colleagues Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors FREE Shi-Yan Ng, Rory Johnson and Lawrence W Stanton   Have you seen? Top TRP channel blamed for burning cold after a tropical fish meal Ciguatera is one of the most common forms of food poisoning, occurring after consumption of fish contaminated with ciguatoxins. New work by Vetter et al reveals the key molecular players that underlie the altered temperature sensation associated with ciguatera. Thomas Voets The EMBO Journal (2012), 31, 3785 - 3787; 10.1038/emboj.2012.255 Abstract | Full text | PDF | Related article Published online: 07 September 2012 Low-hanging fruit: targeting Brdt in the testes Brdt, a testes-specific BET family chromatin reader, regulates sperm development. Pharmacological inhibition of Brdt provides an approach for reversible male contraception. Jessica M Bryant and Shelley L Berger The EMBO Journal (2012), 31, 3788 - 3789; 10.1038/emboj.2012.259 Abstract | Full text | PDF | Related article Published online: 07 September 2012 Birthing histone mRNAs by CSR-1 section Histone pre-mRNAs undergo maturation through a mechanism distinct from all other RNA Pol II transcripts. In C. elegans, 3′-end processing of histone mRNAs depends on the RNAi pathway involving the Argonaute protein CSR-1. Amy E Pasquinelli The EMBO Journal (2012), 31, 3790 - 3791; 10.1038/emboj.2012.254 Abstract | Full text | PDF | Related article Published online: 07 September 2012 RING-between-RINGs—keeping the safety on loaded guns Auto-inhibition of the ‘RING-between-RINGs’-type E3 Ub ligase HOIP is released by its binding partners HOIL-1L or SHARPIN, allowing linear Ub-chain formation via a RING/HECT-hybrid transfer mechanism. Katja K Dove and Rachel E Klevit The EMBO Journal (2012), 31, 3792 - 3794; 10.1038/emboj.2012.260 Abstract | Full text | PDF | Related article | Related article Published online: 07 September 2012 Articles Top Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling Ciguatoxins derived from fish lead to cold allodynia in humans, the perception of intense burning pain in response to mild cooling. A novel mouse model of ciguatoxin-induced cold allodynia reveals that ciguatoxin activates the TRPA1 thermosensitive ion channel to mediate pain perception. Irina Vetter, Filip Touska, Andreas Hess, Rachel Hinsbey, Simon Sattler, Angelika Lampert, Marina Sergejeva, Anastasia Sharov, Lindon S Collins, Mirjam Eberhardt, Matthias Engel, Peter J Cabot, John N Wood, Viktorie Vlachová, Peter W Reeh, Richard J Lewis and Katharina Zimmermann The EMBO Journal (2012), 31, 3795 - 3808; 10.1038/emboj.2012.207 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 July 2012 Bromodomain-dependent stage-specific male genome programming by Brdt The BET family chromatin adaptor Brdt is a master regulator of mammalian spermatogenesis by first co-ordinating testis-specific gene expression starting in meiosis and subsequently controlling genome-wide histone replacement in differentiating spermatids. Jonathan Gaucher, Fayçal Boussouar, Emilie Montellier, Sandrine Curtet, Thierry Buchou, Sarah Bertrand, Patrick Hery, Sylvie Jounier, Arnaud Depaux, Anne-Laure Vitte, Philippe Guardiola, Karin Pernet, Alexandra Debernardi, Fabrice Lopez, Hélène Holota, Jean Imbert, Debra J Wolgemuth, Matthieu Gérard, Sophie Rousseaux and Saadi Khochbin The EMBO Journal (2012), 31, 3809 - 3820; 10.1038/emboj.2012.233 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 24 August 2012 CSR-1 RNAi pathway positively regulates histone expression in C. elegans This study reveals a novel positive role of the RNAi machinery in mRNA expression: in C. elegans, histone mRNA maturation depends on endo-siRNAs bound to the Argonaute protein CSR-1. Daphne C Avgousti, Santhosh Palani, Yekaterina Sherman and Alla Grishok The EMBO Journal (2012), 31, 3821 - 3832; 10.1038/emboj.2012.216 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 August 2012 The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension Like Parkin, the linear ubiquitin chain assembly complex LUBAC functions as a RING/HECT-hybrid ubiquitin ligase, but includes a unique extension that dictates linear ubiquitin linkage specificity. Judith J Smit, Davide Monteferrario, Sylvie M Noordermeer, Willem J van Dijk, Bert A van der Reijden and Titia K Sixma The EMBO Journal (2012), 31, 3833 - 3844; 10.1038/emboj.2012.217 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 August 2012 A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7 The ubiquitin-editing enzyme A20, known to affect NF-κB activation via both catalytic and structural functions, possesses a linear ubiquitin chain binding domain that interferes with the essential NEMO–LUBAC interactions. Kelly Verhelst, Isabelle Carpentier, Marja Kreike, Laura Meloni, Lynn Verstrepen, Tobias Kensche, Ivan Dikic and Rudi Beyaert The EMBO Journal (2012), 31, 3845 - 3855; 10.1038/emboj.2012.240 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 28 August 2012 Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation Crystal structure data reveal the molecular basis of a novel linear ubiquitin chain recognition domain in the ubiquitin editing enzyme A20, which negatively regulates the NF-κB pathway. Fuminori Tokunaga, Hiroshi Nishimasu, Ryuichiro Ishitani, Eiji Goto, Takuya Noguchi, Kazuhiro Mio, Kiyoko Kamei, Averil Ma, Kazuhiro Iwai and Osamu Nureki The EMBO Journal (2012), 31, 3856 - 3870; 10.1038/emboj.2012.241 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 28 August 2012 E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1 E2F transcription factors are well-established cell-cycle regulators. However, E2F7 and E2F8 are essential for vascular development in zebrafish in association with hypoxia inducible transcription factor HIF1 through induction of VEGF-A transcription. Bart G M W Weijts, Walbert J Bakker, Peter W A Cornelissen, Kuo-Hsuan Liang, Frank H Schaftenaar, Bart Westendorp, Charlotte A C M T de Wolf, Maya Paciejewska, Colinda L G J Scheele, Lindsey Kent, Gustavo Leone, Stefan Schulte-Merker and Alain de Bruin The EMBO Journal (2012), 31, 3871 - 3884; 10.1038/emboj.2012.231 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 August 2012 Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells The integrin and TGF-β signalling pathways reciprocally cross-activate in angiogenesis in vivo. Fibronectin promotes TGF-β signalling by inducing the endoglin/ALK1 TGF-β receptor complex, while TGF-β increases α5β1 integrin signalling through binding to endoglin. Hongyu Tian, Karthikeyan Mythreye, Christelle Golzio, Nicholas Katsanis and Gerard C Blobe The EMBO Journal (2012), 31, 3885 - 3900; 10.1038/emboj.2012.246 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 August 2012 Inducible progenitor-derived Wingless regulates adult midgut regeneration in Drosophila Studying molecular mechanisms of intestinal stem cell homeostasis in the Drosophila midgut, Cordero et al report a sole epithelial origin of Wingless during damage-induced tissue regeneration. Julia B Cordero, Rhoda K Stefanatos, Alessandro Scopelliti, Marcos Vidal and Owen J Sansom The EMBO Journal (2012), 31, 3901 - 3917; 10.1038/emboj.2012.248 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 04 September 2012 The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response The POH1/Rpn11 de-ubiquitinase edits ubiquitin chain signals at DNA damage sites, thereby modulating recruitment of break repair factors such as 53BP1 and RAD51. Laura R Butler, Ruth M Densham, Junying Jia, Alexander J Garvin, Helen R Stone, Vandna Shah, Daniel Weekes, Frederic Festy, James Beesley and Joanna R Morris The EMBO Journal (2012), 31, 3918 - 3934; 10.1038/emboj.2012.232 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 August 2012 In vivo SELEX reveals novel sequence and structural determinants of Nrd1-Nab3-Sen1-dependent transcription termination The study identifies sequence elements driving transcriptional termination of ncRNAs by the Nrd1-Nab3-Sen1 (NNS) pathway. Interestingly, these elements also mediate mRNA termination, suggesting that they function as general transcription insulators. Odil Porrua, Fruzsina Hobor, Jocelyne Boulay, Karel Kubicek, Yves D’Aubenton-Carafa, Rajani Kanth Gudipati, Richard Stefl and Domenico Libri The EMBO Journal (2012), 31, 3935 - 3948; 10.1038/emboj.2012.237 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 28 August 2012 Corrigendum Top Mechanism of nucleotide sensing in group II chaperonins Jose H Pereira, Corie Y Ralston, Nicholai R Douglas, Ramya Kumar, Tom Lopez, Ryan P McAndrew, Kelly M Knee, Jonathan A King, Judith Frydman and Paul D Adams The EMBO Journal (2012), 31, 3949 - 3950; 10.1038/emboj.2012.245 Full text | PDF | Supp. info. Published online: 03 October 2012 Advertisement Recommend The EMBO Journal to your institution or corporate library today   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. 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