SciBX: Science-Business eXchange Contents: October 4 2012, Volume 5 / Issue 39

TABLE OF CONTENTS October 4 2012, Volume 5 / Issue 39 Analysis Cover Story Translational Notes Tools The Distillery: Therapeutics Autoimmune disease Cancer Endocrine/metabolic disease Infectious disease Inflammation Musculoskeletal disease Neurology The Distillery: Techniques Assays and screens Disease models Imaging SciBX: Science-Business eXchange Recommend SciBX to your library today SciBx is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. Subscribe to SciBX and you won't miss the next big thing. For more information visit: www.nature.com/scibx.   Trade Secrets A Nature Network blog by BIOENTREPRENEUR Brought to you by Nature Biotechnology Access the insights, advice and commentary from scientists and entrepreneurs building biotech sectors around the world. Join the global dialogue on life science entrepreneurship: http://blogs.nature.com/trade_secrets   Analysis Cover Story Top Slipping past P glycoprotein Kai-Jye Lou doi:10.1038/scibx.2012.1019 NIH researchers have shown that sphingosine 1-phosphate receptor agonists such as Novartis' Gilenya could transiently reduce P glycoprotein–mediated drug efflux and enhance drug delivery to the brain. The group is evaluating the approach for improving drug delivery to brain tumors. Full Text | PDF Translational Notes Top Buddy system for orphan disease Lev Osherovich doi:10.1038/scibx.2012.1020 The Wellcome Trust has launched a program to fund early stage translational research in rare and orphan diseases. The Pathfinder Award Scheme requires academics to pair up with an industry partner at the outset. Full Text | PDF Tools Top Paper point of care Tim Fulmer doi:10.1038/scibx.2012.1021 U.S. researchers have developed a postage stamp–sized diagnostic for hepatotoxicity and have shown that it measured liver enzyme levels in human blood serum. Diagnostics for All has exclusively licensed the device and is running field tests in Vietnam. Full Text | PDF Transferrin PET project Michael J. Haas doi:10.1038/scibx.2012.1022 Memorial Sloan-Kettering Cancer Center researchers have developed a transferrin-based PET imaging agent that could help diagnose prostate cancer with greater sensitivity than 18F-labeled fluorodeoxyglucose. It also can detect a precancerous prostate condition that is not otherwise amenable to imaging. Full Text | PDF Distillery: Therapeutics Autoimmune disease Top Sphingosine 1-phosphate receptor 1 (S1PR1; S1P1; EDG1) doi:10.1038/scibx.2012.1023 Mouse and cell culture studies suggest the S1P1-selective antagonist NIBR-0213 could help treat MS. Full Text | PDF Cancer Top Phosphoinositide-3 kinase (PI3K); poly(AD-ribose) polymerase (PARP); breast cancer 1 early onset (BRCA1); BRCA2 doi:10.1038/scibx.2012.1024 In vitro and mouse studies suggest combining PARP and PI3K inhibitors could help treat metastatic breast cancer. Full Text | PDF Transforming growth factor-β (TGFB; TGFβ); TGFβ receptor II (TGFβ-RII; TGFBR2) doi:10.1038/scibx.2012.1025 Mouse studies suggest inhibiting TGFβ signaling could help improve chemotherapy efficacy in breast cancer. Full Text | PDF p21 Protein (Cdc42 Rac)-activated kinase 1 (PAK1) doi:10.1038/scibx.2012.1026 In vitro and mouse studies suggest inhibiting PAK1 could help treat K-Ras–driven tumors. Full Text | PDF Unknown doi:10.1038/scibx.2012.1027 Mouse and cell culture studies suggest a derivative of griseofulvin that inhibits centrosomal clustering could help treat cancer. Full Text | PDF Cyclin dependent kinase (CDK); p53 doi:10.1038/scibx.2012.1028 In vitro and mouse studies identified DLBCL gene signatures that could help predict prognosis and guide targeted therapy. Full Text | PDF Myeloid leukemia cell differentiation protein (MCL1) doi:10.1038/scibx.2012.1029 In vitro studies identified a small molecule MCL1 inhibitor that could help treat leukemia. Full Text | PDF Enhancer of zeste homolog 2 (EZH2); poly(ADP-ribose) polymerase-1 (PARP-1) doi:10.1038/scibx.2012.1030 A study in cell culture and in patient tissue suggests inhibiting PARP-1 or EZH2 could help treat small cell lung cancer (SCLC). Full Text | PDF Endocrine/metabolic disease Top Not applicable doi:10.1038/scibx.2012.1031 Human studies suggest genomic profiling of gut microbiota might help predict risk for type 2 diabetes. Full Text | PDF Infectious disease Top Mucin 5AC oligomeric mucus/gel-forming (MUC5AC) doi:10.1038/scibx.2012.1032 Mouse studies suggest increasing MUC5AC levels in the lungs could help protect against influenza infection. Full Text | PDF Inflammation Top Solute carrier family 26 member 9 (SLC26A9) doi:10.1038/scibx.2012.1033 A mouse and patient genetic study suggests activating SLC26A9 could help treat asthma-associated mucus obstruction. Full Text | PDF Musculoskeletal disease Top Bone morphogenetic protein 2 (BMP2) doi:10.1038/scibx.2012.1034 Rat studies identified a benzoic acid–based BMP2 stimulator that could be useful for bone repair. Full Text | PDF Neurology Top β-Amyloid 42 doi:10.1038/scibx.2012.1035 A high throughput screen identified small molecule inhibitors of β-amyloid 42 aggregation that could help treat AD. Full Text | PDF Methyl CpG binding protein 2 (MECP2; RTT) doi:10.1038/scibx.2012.1036 Mouse studies suggest ketamine could help treat Rett syndrome. Full Text | PDF Not applicable doi:10.1038/scibx.2012.1037 A study in rats suggests neural stem cell transplantation could help treat SCI. Full Text | PDF Distillery: Techniques Assays and screens Top Ligand-based, receptor-capturing (LRC) technology to identify cell surface receptors of therapeutic or pathologic ligands doi:10.1038/scibx.2012.1038 LRC technology could be used to identify cell surface receptor targets of ligands. Full Text | PDF Transforming growth factor-α (TGFA; TGFα) shedding assay to detect G protein–coupled receptor (GPR) ligands doi:10.1038/scibx.2012.1039 A TGFa shedding assay could help identify GPR ligands. Full Text | PDF Disease models Top Mice with conditional B cell–specific knockout of TANK-binding kinase 1 (Tbk1) doi:10.1038/scibx.2012.1040 Mice with conditional B cell–specific knockout of Tbk1 could be useful for identifying new targets and treatments for autoimmune diseases. Full Text | PDF Mouse model for neurological features of myotonic dystrophy type 1 (DM1) doi:10.1038/scibx.2012.1041 A mouse model for DM1 could be useful for studying neurological features of the disease. Full Text | PDF Xenopus model for oligodendrocyte myelination doi:10.1038/scibx.2012.1042 A Xenopus model for myelination could help identify multiple sclerosis (MS) therapeutics. Full Text | PDF Zebrafish model for narcolepsy doi:10.1038/scibx.2012.1043 A zebrafish model for narcolepsy could be used to identify new targets or therapeutic leads for the sleep disorder. Full Text | PDF Imaging Top 89Zr-transferrin agent for in vivo PET imaging of transferrin receptor protein 1 (TFRC; TFR; CD71)-expressing cancers doi:10.1038/scibx.2012.1044 A 89Zr-transferrin PET imaging agent could help detect prostate and other cancers. Full Text | PDF You have been sent this Table of Contents Alert because you have opted in to receive it. 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