Nature Biotechnology Contents: Volume 30 pp 897 - 1008

Advertisement In an iDeal world, ChIP-Seq would work. Designed for high-quality ChIP for any sequencing platform, the iDeal ChIP-Seq kit is the only validated solution for the two main commercial sequencers on the market. Diagenode simplifies epigenetics research with ChIP and DNA methylation kits, sonication instruments (Bioruptor®), and unique antibodies. See why our superior epigenetics and NGS solutions should be your solution. TABLE OF CONTENTS October 2012 Volume 30, Issue 10 In This Issue Editorial Focus News Bioentrepreneur Correspondence Commentaries Features News and Views Computational Biology Research Careers and Recruitment Advertisement Save on best-in-class personal flow cytometry With a combined value package, you can save 10% on the BD Accuri™ C6 personal flow cytometer and 40% on high quality BD Pharmingen™ reagents for 2 full years. There's never been a better time to buy and get the best-in-class power, flexibility, and insight personal flow cytometry can offer. Flow cytometry within reach™. bdbiosciences.com/go/accuri Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Slide Presentation: The best of both worlds – combining PacBio with short read technology for improved de novo genome assembly Lex Nederbragt, PhD, University of Oslo, reviews the challenges of de novo assembly and the unique benefits of long read sequencing to span repeats and heterozygous regions, then applies the technique to create a draft of the Atlantic cod genome.   In This Issue Top In this issue   ppvii - vii doi:10.1038/nbt.2400 Focus Top Commercializing Biomedical Research The present system for commercializing biomedical research remains woefully inefficient and underpowered. This focus issue of Nature Biotechnology highlights new approaches to facilitate clinical translation of academic discovery. Table of Contents Editorial Top Expanding the innovation pool   p897 doi:10.1038/nbt.2396 The biotech investment community needs to look beyond the existing pools of funding and talent to galvanize biomedical innovation. News Top SGLT2 inhibitors race to enter type-2 diabetes market   pp899 - 900 Cormac Sheridan doi:10.1038/nbt1012-899 Social networks attempt to spark academic-university collaborations   pp901 - 903 Arlene Weintraub doi:10.1038/nbt1012-901 Elan splits in two   p902 Allison Proffitt doi:10.1038/nbt1012-902 Monoclonals Lego factory   p903 doi:10.1038/nbt1012-903a Novel Indian clotbuster   p903 Killugudi Jayaraman doi:10.1038/nbt1012-903b Amgen to shut key plant   p904 Karen Carey doi:10.1038/nbt1012-904a Big players jostle for pole position in muscular dystrophy   pp904 - 905 Nuala Moran doi:10.1038/nbt1012-904b GM beets approved[mdash]finally   p906 Emily Waltz doi:10.1038/nbt1012-906a FDA prevails in stem cell trial   p906 Laura DeFrancesco doi:10.1038/nbt1012-906b Clinical setbacks reduce IGF-1 inhibitors to cocktail mixers   pp906 - 907 Malorye Allison doi:10.1038/nbt1012-906c Merck Serono spinouts   p907 Brian Orelli doi:10.1038/nbt1012-907 Around the world in a month   p908 doi:10.1038/nbt1012-908 Editors' Pick RaNA Therapeutics   p909 Cormac Sheridan doi:10.1038/nbt1012-909 This Cambridge, Massachusetts-based startup aims to use oligonucleotides to downregulate long noncoding RNAs in epigenetic disorders and to modulate crop traits. Data Page Trends in biotech literature 2011   p910 Wayne Peng doi:10.1038/nbt.2384 Advertisement Staring at complex Omics data sets? A partnership between Waters and Nonlinear Dynamics is ready to help you visualize data and extract reliable results: the Waters Omics Research Plaform with TransOmics Informatics. Nonlinear's software unlocks the potential of content-rich data generated by Waters' ion mobility MS technology in proteomics and metabolomics experiments. Bioentrepreneur Top The changing face of corporate venturing in biotechnology   pp911 - 915 Georg von Krogh, Boris Battistini, Fotini Pachidou and Pius Baschera doi:10.1038/nbt.2383 Correspondence Top The Green Climate Fund as a patent pool for innovations   pp916 - 917 Menno van der Veen doi:10.1038/nbt.2378 A cross-platform toolkit for mass spectrometry and proteomics   pp918 - 920 Matthew C Chambers, Brendan Maclean, Robert Burke, Dario Amode, Daniel L Ruderman, Steffen Neumann, Laurent Gatto, Bernd Fischer, Brian Pratt, Jarrett Egertson, Katherine Hoff, Darren Kessner, Natalie Tasman, Nicholas Shulman, Barbara Frewen, Tahmina A Baker, Mi-Youn Brusniak, Christopher Paulse, David Creasy, Lisa Flashner, Kian Kani, Chris Moulding, Sean L Seymour, Lydia M Nuwaysir, Brent Lefebvre, Frank Kuhlmann, Joe Roark, Paape Rainer, Suckau Detlev, Tina Hemenway, Andreas Huhmer, James Langridge, Brian Connolly, Trey Chadick, Krisztina Holly, Josh Eckels, Eric W Deutsch, Robert L Moritz, Jonathan E Katz, David B Agus, Michael MacCoss, David L Tabb and Parag Mallick doi:10.1038/nbt.2377 Assessing unintended hybridization-induced biological effects of oligonucleotides   pp920 - 923 Morten Lindow, Hans-Peter Vornlocher, Donald Riley, Douglas J Kornbrust, Julja Burchard, Laurence O Whiteley, Joanne Kamens, James D Thompson, Saraswathy Nochur, Husam Younis, Steven Bartz, Joel Parry, Nicolay Ferrari, Scott P Henry and Arthur A Levin doi:10.1038/nbt.2376 Innovative drugs and vaccines in China, India and Brazil   pp923 - 926 Rahim Rezaie, Anita M McGahan, Abdallah S Daar and Peter A Singer doi:10.1038/nbt.2380 Commentaries Top Nonprofit foundations for open-source biomedical technology development   pp928 - 932 John V Frangioni doi:10.1038/nbt.2392 For academic discoveries eschewed by traditional venture capital business models, there is now an alternative path. Why universities should step up in venture investing   pp933 - 936 Amanda Christini doi:10.1038/nbt.2390 University funds have a unique opportunity to bridge the gap to commercialization. Patterns of technological innovation in biotech   pp937 - 943 Laura M McNamee and Fred D Ledley doi:10.1038/nbt.2389 Applying theories of innovation to biotech; an analysis of the evolution of three classes of therapeutic biotechnologies. Features Top Partnering with the professor   pp944 - 952 Beth Schachter doi:10.1038/nbt.2385 There was a time when academia viewed industry simply as a cash cow; today, it's all about sharing common goals and mutual respect for cultural differences. Patents Accountability in patenting of federally funded research   pp953 - 956 Arti K Rai and Bhaven N Sampat doi:10.1038/nbt.2382 New data indicating underreporting of federal funding in academic biomedical patents highlight the pressing need for greater transparency under the Bayh-Dole Act. Recent patent applications in biomaterials   p957 doi:10.1038/nbt.2395 Advertisement Human and Mouse Exome NGS $798/each, guaranteed coverage RNA-Seq from $798: 20 million guaranteed reads 4-6 weeks, fastest turnaround time in the industry http://www.otogenetics.com/ News and Views Top Transforming lymph nodes into tissue factories   pp958 - 959 Johannes L Zakrzewski, Andrea Z Tuckett and Marcel R M van den Brink doi:10.1038/nbt.2388 Transplanting donor cells into lymph nodes regenerates liver, pancreas and thymus function in mice. Discovering ligand-receptor interactions   pp959 - 961 Sarah A Slavoff and Alan Saghatelian doi:10.1038/nbt.2373 A new probe identifies cell-surface receptors bound by known ligands. Who's who in the plant root microbiome?   pp961 - 962 Penny R Hirsch and Tim H Mauchline doi:10.1038/nbt.2387 Metagenomics reveals the identities of the microorganisms that make up the endophytic and rhizosphere microbiomes of the model plant Arabidopsis thaliana. Biotechnology JOBS of the week UCD Interdisciplinary Chair in the Business of Biotechnology University College Dublin & Élan Corporation Plc. Postdoctoral Researcher Institute of Biotechnology of the Czech Academy of Sciences Postdoctoral Walloon Excellence in Life Sciences and Biotechnology More Science jobs from Biotechnology EVENT University of California, Los Angeles Biotechnology Vendor Showcase™ Event October 4, 2012 Los Angeles, CA, USA More science events from Computational Biology Top Profile John Cottrell, David Creasy & Darryl Pappin   p963 doi:10.1038/nbt.2393 Pioneers in proteomics data analysis reflect on what to focus on in computational biology. Research Top Perspective Commercializing biomedical research through securitization techniques   pp964 - 976 Jose-Maria Fernandez, Roger M Stein and Andrew W Lo doi:10.1038/nbt.2374 The authors propose that the increasing risk of biopharma investing can be reduced through megafunds that support many biomedical programs and attract investment from large institutions such as pension funds. Articles The mouse lymph node as an ectopic transplantation site for multiple tissues   pp976 - 983 Junji Komori, Lindsey Boone, Aaron DeWard, Toshitaka Hoppo and Eric Lagasse doi:10.1038/nbt.2379 Komori et al. show that hepatocytes, pancreatic islets and thymocytes flourish in the mouse lymph node, suggesting that lymph nodes could serve as a transplantation site for cell therapies. Selective enrichment of newly synthesized proteins for quantitative secretome analysis   pp984 - 990 Katrin Eichelbaum, Markus Winter, Mauricio Berriel Diaz, Stephan Herzig and Jeroen Krijgsveld doi:10.1038/nbt.2356 By combining two metabolic labeling techniques, Eichelbaum et al. detect and quantify large numbers of secreted proteins, including low-abundance proteins such as cytokines. Letters Synthetic two-way communication between mammalian cells   pp991 - 996 William Bacchus, Moritz Lang, Marie Daoud El-Baba, Wilfried Weber, Jorg Stelling and Martin Fussenegger doi:10.1038/nbt.2351 Bacchus et al. describe the first experiments in mammalian cells that distribute complex behavior across several types of engineered cells, thereby mimicking natural multicellular systems. Direct identification of ligand-receptor interactions on living cells and tissues   pp997 - 1001 Andreas P Frei, Ock-Youm Jeon, Samuel Kilcher, Hansjoerg Moest, Lisa M Henning, Christian Jost, Andreas Pluckthun, Jason Mercer, Ruedi Aebersold, Erick M Carreira and Bernd Wollscheid doi:10.1038/nbt.2354 Frei et al. show that a new tri-functional reagent identifies unknown cell-surface receptors bound by known ligands on living cells. RNA processing enables predictable programming of gene expression   pp1002 - 1006 Lei Qi, Rachel E Haurwitz, Wenjun Shao, Jennifer A Doudna and Adam P Arkin doi:10.1038/nbt.2355 Qi et al. control the expression levels of transgenes using bacterial CRISPR RNA-processing technology. Careers and Recruitment Top Human research capacity in Chinese agbiotech   p1007 Jikun Huang, Ruifa Hu, Jinyang Cai and Xiaobing Wang doi:10.1038/nbt.2386 China's recent R&D investment has resulted in a growth in research capacity and personnel, particularly in the agbiotech sector. People People   p1008 doi:10.1038/nbt.2397 Advertisement New Partnering Opportunities in Alzheimer's Disease! A comprehensive interactive dashboard from Relay Technology Management. Click here for more information on Alzheimer's partnering opportunities.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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