Molecular Systems Biology - New articles published 9 October 2012

Latest Articles 9th October 2012   Featured Article Research Article   Web feeds About Open access Advertisement Join Keystone Symposia for: Structural Analysis of Supramolecular Assemblies by Hybrid Methods March 3-7, 2013 Granlibakken Resort, Tahoe City, California, USA Scientific Organizers: Andrej Sali, Brian T. Chait and David Baker Abstract & Scholarship Deadline: November 5, 2012 www.keystonesymposia.org/13C1   Featured Article Cell-cycle regulation of NOTCH signaling during C. elegans vulval development Through an iterative process of computational modeling, prediction, and experimentation, a molecular synchronization mechanism is revealed by which the cell-cycle regulates Notch signaling to allow the formation of a stable cell fate pattern. Stefanie Nusser-Stein, Antje Beyer, Ivo Rimann, Magdalene Adamczyk, Nir Piterman, Alex Hajnal & Jasmin Fisher Molecular Systems Biology 8:618; doi:10.1038/msb.2012.51; published 9 October 2012 Full Text | PDF | Supp. Inf. | Review Process Research Article The inoculum effect and band-pass bacterial response to periodic antibiotic treatment The efficacy of many antibiotics decreases with increasing bacterial density, a phenomenon called the ‘inoculum effect’ (IE). This study reveals that, for ribosome-targeting antibiotics, IE is due to bistable inhibition of bacterial growth, which reduces the efficacy of certain treatment frequencies. Cheemeng Tan, Robert Phillip Smith, Jaydeep K Srimani, Katherine A Riccione, Sameer Prasada, Meta Kuehn & Lingchong You Molecular Systems Biology 8:617; doi:10.1038/msb.2012.49; published 9 October 2012 Full Text | PDF | Supp. Inf. | Review Process

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