Nature Reviews Immunology Contents October 2012 Volume 12 Number 10 pp 679-740

TABLE OF CONTENTS
October 2012 Volume 12 Number 10
Impact Factor 33.287 *	In this issue Research Highlights Reviews Perspectives Correspondence Also this month  Featured article: Dietary influences on intestinal immunity Marc Veldhoen & Verena Brucklacher-Waldert
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RESEARCH HIGHLIGHTS Top Immunometabolism: Immune decisions weigh heavily on us p679 | doi:10.1038/nri3303 Lymphotoxin signalling reshapes the intestinal microbiota to promote obesity. PDF B cell signalling: Discouraging encounters p680 | doi:10.1038/nri3305 BCR signals during B cell development determine the level of B cell anergy. PDF Immunotherapy: Isolation of TCM cells for tumour immunotherapy p680 | doi:10.1038/nri3309 A high IL2/IFNG mRNA ratio identifies rare tumour-specific T cells that can persist in humans following adoptive transfer. PDF Tumour immunology: Differing roles for MYD88 in carcinogenesis p681 | doi:10.1038/nri3304 MYD88 signalling can have pro- or anti-tumorigenic effects in distinct cancer models. PDF Immunotherapy: Unlicensed to kill p682 | doi:10.1038/nri3301 Unlicensed natural killer cells are important in the response of patients with high-risk neuroblastoma to treatment with GD2-specific monoclonal antibodies. PDF IN THE NEWS Antibodies drive an AIDS-like syndrome p682 | doi:10.1038/nri3306 Researchers identify a new AIDS-like disease caused by IFNγ-specific autoantibodies. PDF Autoimmunity: The lung takes over CNS traffic control p682 | doi:10.1038/nri3308 Activated autoimmune T cells acquire a migratory phenotype in the lungs prior to CNS invasion. PDF T cell responses: Dancing in the dark p684 | doi:10.1038/nri3310 Inflammatory monocytes activate memory CD8+ T cells in an antigen-independent manner. PDF Innate immunity: Multitasking NET makers p684 | doi:10.1038/nri3314 Neutrophils releasing NETs remain functional in response to infection. PDF IN BRIEF Lymphoid organogenesis: Lymph node stroma and adipocytes: the link | Lymphoid architecture: Immune cell cartography | Infection: TFH cell dynamics in SIV and HIV infection | T cell signalling: Balancing regulatory and self-reactive T cells | Tumour immunology: Splenic myeloid cells tolerize tumour-specific T cells | Infectious disease: Targeting M. tuberculosis for autophagy PDF Immunology JOBS of the week Technical (Field) Sales Specialist-Immunology / Cells South c30k + 20% OTE Hudson Shribman Scientfic Recruitment Postdoctoral Fellow in Bioengineering / Pharmaceutical Sciences / Immunology University of Michigan - Ann Arbor Postdoctoral Fellowship in Human Immunology University of Cape Town, South Africa Assistant Professor of Immunology University of São Paulo, USP Postdoc – Immunology Cedars-Sinai Medical Center More Science jobs from Immunology EVENT Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances 02.-05.12.12 FL, US More science events from
REVIEWS		Top
Evolutionary conflicts between viruses and restriction factors shape immunity Nisha K. Duggal & Michael Emerman p687 | doi:10.1038/nri3295 The evolutionary 'arms race' between host restriction factors and viral antagonists has left a genetic 'signature' that can tell us much about the innate immune response to past and present viral infections. Abstract | Full Text | PDF
Dietary influences on intestinal immunity Marc Veldhoen & Verena Brucklacher-Waldert p696 | doi:10.1038/nri3299 Dietary habits have always been associated with the robustness of the immune system. Here, the molecular links between dietary compounds and immune regulation in the intestine are discussed, with a focus on the central role of nuclear receptors. Abstract | Full Text | PDF
Tools to therapeutically harness the human antibody response Patrick C. Wilson & Sarah F. Andrews p709 | doi:10.1038/nri3285 Here, Patrick Wilson and Sarah Andrews discuss the strategies that have been used to identify rare broadly neutralizing antibodies, focusing on the recent advances in isolating such antibodies naturally generated in response to HIV and influenza virus infection or vaccination. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Unconventional recognition of peptides by T cells and the implications for autoimmunity James F. Mohan & Emil R. Unanue p721 | doi:10.1038/nri3294 In this Opinion, the authors describe an unconventional form of peptide recognition that can allow potentially autoreactive CD4+ T cells to escape thymic regulation. They explain how these T cells respond to unstable peptide—MHC complexes that evade H2-DM-mediated editing, and they discuss the implications for autoimmunity. Abstract | Full Text | PDF
VIEWPOINT The impact of probiotics and prebiotics on the immune system Todd R. Klaenhammer, Michiel Kleerebezem, Matthias Volkmar Kopp & Maria Rescigno p728 | doi:10.1038/nri3312 Here, Nature Reviews Immunology asks four experts to share their thoughts on the ability of probiotics and prebiotics to modulate the immune system and influence disease. Can these products have a therapeutic application for inflammatory diseases? Abstract | Full Text | PDF
SCIENCE AND SOCIETY Consortium biology in immunology: the perspective from the Immunological Genome Project Christophe Benoist, Lewis Lanier, Miriam Merad, Diane Mathis & the Immunological Genome Project p734 | doi:10.1038/nri3300 What is the role and value of consortium biology in immunology? Here, the participants of the Immunological Genome Project share their thoughts on the benefits and shortcomings of 'big science' and discuss how the immunology community can profit from engaging in this type of discovery-led research. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial Christopher Horvath, Laura Andrews, Andreas Baumann, Lauren Black, Diann Blanset, Joy Cavagnaro, Kenneth L. Hastings, David L. Hutto, Timothy K. MacLachlan, Mark Milton, Theresa Reynolds, Stan Roberts, Mark Rogge, Jennifer Sims, George Treacy, Garvin Warner & James D. Green p740 | doi:10.1038/nri3192-c1 Full Text | PDF
Response to 'Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial' Thomas Hünig p740 | doi:10.1038/nri3192-c2 Full Text | PDF
Corrigendum: Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial Christopher Horvath, Laura Andrews, Andreas Baumann, Lauren Black, Diann Blanset, Joy Cavagnaro, Kenneth L. Hastings, David L. Hutto, Timothy K. MacLachlan, Mark Milton, Theresa Reynolds, Stan Roberts, Mark Rogge, Jennifer Sims, George Treacy, Garvin Warner & James D. Green p740 | doi:10.1038/nri3302 Full Text | PDF
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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