| | | Can't view this email? Click here to view in your browser. | | | | | Volume 489 Number 7416 | | | | nature | | The science that matters. Every week. | | | | | | | | |
| | | | | | | | | | | | | | Bridging the Gap between Structure and Biological Function Research in biosciences is increasingly focused on understanding the correlations between structure and function. Correlative investigations, combining fluorescence microscopy images with SEM images of the same region of interest offer great potential in this respect. Read about the interface for correlative microscopy Shuttle&Find and download two free white papers. | | | | | | | | | | |
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| | | | | | | | | | An anatomically comprehensive atlas of the adult human brain transcriptome | | This high-resolution map of genome-wide gene expression, freely available at www.brain-map.org, allows comparisons between the brains of humans and other animals, and will be useful in studies of human neurological and psychiatric disease. An early observation from the data is a human-specific pattern for the calcium-binding protein CALB1 in the hippocampus compared to mouse and rhesus monkey. | | | | | | | | | | | | | | Afternoon rain more likely over drier soils | | Most climate models suggest that wetter soils promote higher atmospheric moisture content and favour the local development of storms. But this analysis of global precipitation data from a combination of weather satellites shows that afternoon precipitation is more likely over dry soil than over wet soil. | | | | | | | | | | | | | | Spontaneous giving and calculated greed | | Many people are willing to make sacrifices for the common good, but little is known about the cognitive mechanisms underlying such cooperative behaviour. This study uses a series of ten varied experimental designs to establish whether we are intuitively predisposed to cooperate or to act selfishly. And it seems our gut response is to cooperate, but given more time to think, self-interest undermines collective action and we become less generous. | | | | | | | | | | | | | | | | | | | | | | | | The new NanoZoomer-XR redefines the art of whole-slide imaging with hassle-free, error-free, and blur-free scanning. This high-throughput scanner quickly and automatically scans up to 320 slides. It is extremely easy to use, and offers accurate, error-free scanning and automatic quality checking. These features, coupled with an outstanding optics system and real-time dynamic focus, result in images of top tier quality and clarity. | | | | | | | | | | | | | | | | | | | | | | | In this week's podcast: why we are cooperative by nature, transforming waste heat into electricity, and what the brain is doing when it's resting. | | | | | | | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | Through the gaps ▶ | | | | A 20-year campaign of scientific fraud says as much about the research community as it does about the perpetrator. The system that allowed such deception to continue must be reformed. | | | | | | | | | | | | Extreme weather ▶ | | | | Better models are needed before exceptional events can be reliably linked to global warming. | | | | | | | | | | | | Return to sender ▶ | | | | The bid to halt air transport of lab animals poses an imminent threat to biomedical research. | | | | | | | | | | | | | | | | | | | | | | | | Seven days: 14–20 September 2012 ▶ | | | | The week in science: Japan to phase out nuclear power by 2030s, BGI buys into Complete Genomics, and archaeologists claim to have found the skeleton of English king Richard III. | | | | | | | | | | | | | | | | | | | | Lab-animal flights squeezed ▶ | | | | Two biggest cargo carriers affirm that they will not ship mammals and non-human primates, as activist pressure mounts to stop research-animal airlifts. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Forest fires: Burn out ▶ | | | | Forests in the American west are under attack from giant fires, climate change and insect outbreaks. Some ecosystems will never be the same. | | | | | | | | | | | | Neuroscience: Idle minds ▶ | | | | Neuroscientists are trying to work out why the brain does so much when it seems to be doing nothing at all. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Q&A: Collision creator ▶ | | | | Julius von Bismarck is the first artist in residence at the particle-physics laboratory CERN, near Geneva in Switzerland. As he prepares to give the final lecture of his residency, he talks about whipping mountains, hacking photographs and digging into the history of invention. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
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| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | The oyster genome reveals stress adaptation and complexity of shell formation OPEN ▶ | | | | Guofan Zhang, Xiaodong Fang, Ximing Guo, Li Li, Ruibang Luo et al. | | | | The sequencing and assembly of the highly polymorphic oyster genome through a combination of short reads and fosmid pooling, complemented with extensive transcriptome analysis of development and stress response and proteome analysis of the shell, provides new insight into oyster biology and adaptation to a highly changeable environment. | | | | | | | | | | | | Genomic analysis of a key innovation in an experimental Escherichia coli population ▶ | | | | Zachary D. Blount, Jeffrey E. Barrick, Carla J. Davidson & Richard E. Lenski | | | | By combining full-genome sequencing and ‘evolutionary replay’ experiments to dissect the origin of aerobic citrate use in an experimental Escherichia coli population over 40,000 generations and 2 decades, the authors unveil a 3-step process in which potentiation makes a trait possible, actualization makes the trait manifest and refinement makes it effective. | | | | | | | | | | | | Compensatory dendritic cell development mediated by BATF–IRF interactions ▶ | | | | Roxane Tussiwand, Wan-Ling Lee, Theresa L. Murphy, Mona Mashayekhi, Wumesh KC et al. | | | | The roles of BATF transcription factors in dendritic cell differentiation are studied, providing evidence for molecular compensation by related family members; compensation is based on the interaction of the BATF leucine zipper domains with IRF factors to mediate cooperative gene activation. | | | | | | | | | | | | Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive ▶ | | | | Julia C. Lemos, Matthew J. Wanat, Jeffery S. Smith, Beverly A. S. Reyes, Nick G. Hollon et al. | | | | The neuropeptide corticotropin-releasing factor (CRF) acts in the nucleus accumbens of mice to increase dopamine release through coactivation of CRF receptor 1 (CRFR1) and CRFR2, but exposure to severe stress results in loss of this regulation and a switch in the reaction to CRF from appetitive to aversive. | | | | | | | | | | | | BATF–JUN is critical for IRF4-mediated transcription in T cells ▶ | | | | Peng Li, Rosanne Spolski, Wei Liao, Lu Wang, Theresa L. Murphy et al. | | | | The pleiotropic transcription factor IRF4 is shown to regulate CD4+ T-cell differentiation and TH17 function through cooperative binding interactions with BATF and JUN family proteins via AP1–IRF4 composite elements (AICEs). | | | | | | | | | | | | Broad and potent neutralization of HIV-1 by a gp41-specific human antibody ▶ | | | | Jinghe Huang, Gilad Ofek, Leo Laub, Mark K. Louder, Nicole A. Doria-Rose et al. | | | | A novel neutralizing antibody from a healthy HIV-1-infected donor that is specific for the membrane proximal region of gp41 is reported; the antibody has high potency and breadth, is not autoreactive and does not bind phospholipids. | | | | | | | | | | | | Cross-neutralization of influenza A viruses mediated by a single antibody loop ▶ | | | | Damian C. Ekiert, Arun K. Kashyap, John Steel, Adam Rubrum, Gira Bhabha et al. | | | | The crystal structure of an influenza antibody that recognizes a small, conserved site in the variable receptor-binding domain of HA is described; this antibody shows broad neutralization across multiple subtypes of influenza A virus through an antibody–antigen interaction dominated by a single heavy-chain complementarity-determining region 3 loop. | | | | | | | | | | | | FTO genotype is associated with phenotypic variability of body mass index ▶ | | | | Jian Yang, Ruth J. F. Loos, Joseph E. Powell, Sarah E. Medland, Elizabeth K. Speliotes et al. | | | | A meta-analysis of genome-wide association studies of phenotypic variation for height and body mass index in human populations using 170,000 samples shows that one single nucleotide polymorphism at the FTO locus, which is associated with obesity, is also associated with phenotypic variation. | | | | | | | | | | | | | | | | | | | | | | | | An anatomically comprehensive atlas of the adult human brain transcriptome ▶ | | | | Michael J. Hawrylycz, Ed S. Lein, Angela L. Guillozet-Bongaarts, Elaine H. Shen, Lydia Ng et al. | | | | Laser microdissection and microarrays are used to assess 900 precise subdivisions of the brains from three healthy men with 60,000 gene expression probes; the resulting atlas allows comparisons between humans and other animals, and will facilitate studies of human neurological and psychiatric diseases. | | | | | | | | | | | | Structural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexes ▶ | | | | Isabelle Baconguis & Eric Gouaux | | | | Acid-sensing ion channels (ASICs) are voltage-independent ion channels that participate in a broad range of biological processes, including nociception and mechanosensation; here X-ray crystal structures of the complexes of chicken ASIC1a with psalmotoxin, a peptide toxin from tarantula, indicate that toxin binding triggers an expansion of the extracellular vestibule and stabilization of the open channel pore. | | | | | | | | | | | | Spontaneous giving and calculated greed ▶ | | | | David G. Rand, Joshua D. Greene & Martin A. Nowak | | | | Economic games are used to investigate the cognitive mechanisms underlying cooperative behaviour, and show that intuition supports cooperation in social dilemmas, whereas reflection can undermine these cooperative impulses. | | | | | | | | | | | | Sex-specific volatile compounds influence microarthropod-mediated fertilization of moss ▶ | | | | Todd N. Rosenstiel, Erin E. Shortlidge, Andrea N. Melnychenko, James F. Pankow & Sarah M. Eppley | | | | Volatile scents of moss Ceratodon purpureus show sex-specific differences and are similar in chemical diversity to those of plant–insect pollination mutualisms; and moss-dwelling microarthropods, whose presence increases C. purpureus fertilization rates, prefer scents of reproductive female C. purpureus to reproductive males, indicating a scent-based ‘plant–pollinator-like’ relationship between mosses and microarthropods. | | | | | | | | | | | | Attention deficits without cortical neuronal deficits ▶ | | | | Alexandre Zénon & Richard J. Krauzlis | | | | Transient inactivation of the superior colliculus in primates during a motion-change-detection task is shown to lead to large deficits in visual attention while the enhanced response of neurons in the visual cortex to attended stimuli remains unchanged; this shows that processes independent of those occurring in the visual cortex have key roles in visual attention. | | | | | | | | | | | | | | | | | | | | A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality ▶ | | | | Bethany A. Buckley, Kirk B. Burkhart, Sam Guoping Gu, George Spracklin, Aaron Kershner et al. | | | | Double-stranded RNA interference (RNAi) in Caenorhabditis elegans is heritable; here a genetic screen for factors required for RNAi inheritance identifies the nuclear-localized Argonaute gene hrde-1, which acts in the germ cells of progeny to promote multigenerational inheritance of silencing and, also, germline immortality. | | | | | | | | | | | | | | | | Structure of the haptoglobin–haemoglobin complex ▶ | | | | Christian Brix Folsted Andersen, Morten Torvund-Jensen, Marianne Jensby Nielsen, Cristiano Luis Pinto de Oliveira, Hans-Petter Hersleth et al. | | | | This study reports the crystal structure of porcine haptoglobin in complex with haemoglobin at 2.9 Å resolution; this provides a structural basis of haptoglobin-mediated recognition of haemoglobin, and insight into the protective role of haptoglobin at the atomic level. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
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| | | | | | | | | | | | | | | | | | | | | | | | | | Pulsed electron paramagnetic resonance spectroscopy powered by a free-electron laser ▶ | | | | S. Takahashi, L.-C. Brunel, D. T. Edwards, J. van Tol, G. Ramian et al. | | | | A free-electron laser is used to power a pulsed electron paramagnetic resonance spectrometer at 240 GHz, demonstrating a range of experimental possibilities such as the manipulation of spin-1/2 systems with 6-ns pulses and the measurement of ultrashort decoherence times. | | | | | | | | | | | | High-performance bulk thermoelectrics with all-scale hierarchical architectures ▶ | | | | Kanishka Biswas, Jiaqing He, Ivan D. Blum, Chun-I Wu, Timothy P. Hogan et al. | | | | Controlling the structure of thermoelectric materials on all length scales (atomic, nanoscale and mesoscale) relevant for phonon scattering makes it possible to increase the dimensionless figure of merit to more than two, which could allow for the recovery of a significant fraction of waste heat with which to produce electricity. | | | | | | | | | | | | | | | | Structure of the haptoglobin–haemoglobin complex ▶ | | | | Christian Brix Folsted Andersen, Morten Torvund-Jensen, Marianne Jensby Nielsen, Cristiano Luis Pinto de Oliveira, Hans-Petter Hersleth et al. | | | | This study reports the crystal structure of porcine haptoglobin in complex with haemoglobin at 2.9 Å resolution; this provides a structural basis of haptoglobin-mediated recognition of haemoglobin, and insight into the protective role of haptoglobin at the atomic level. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | A single-atom electron spin qubit in silicon ▶ | | | | Jarryd J. Pla, Kuan Y. Tan, Juan P. Dehollain, Wee H. Lim, John J. L. Morton et al. | | | | The coherent manipulation of an individual electron spin qubit bound to a single phosphorus donor atom in natural silicon provides an excellent platform on which to build a scalable quantum computer. | | | | | | | | | | | | | | | | | | | | A magnified young galaxy from about 500 million years after the Big Bang ▶ | | | | Wei Zheng, Marc Postman, Adi Zitrin, John Moustakas, Xinwen Shu et al. | | | | Gravitationally magnified images of a faint galaxy from only 500 million years after the Big Bang suggest that galaxies of that age may be the dominant source of the radiation responsible for the re-ionization of the intergalactic medium. | | | | | | | | | | | | Pulsed electron paramagnetic resonance spectroscopy powered by a free-electron laser ▶ | | | | S. Takahashi, L.-C. Brunel, D. T. Edwards, J. van Tol, G. Ramian et al. | | | | A free-electron laser is used to power a pulsed electron paramagnetic resonance spectrometer at 240 GHz, demonstrating a range of experimental possibilities such as the manipulation of spin-1/2 systems with 6-ns pulses and the measurement of ultrashort decoherence times. | | | | | | | | | | | | High-performance bulk thermoelectrics with all-scale hierarchical architectures ▶ | | | | Kanishka Biswas, Jiaqing He, Ivan D. Blum, Chun-I Wu, Timothy P. Hogan et al. | | | | Controlling the structure of thermoelectric materials on all length scales (atomic, nanoscale and mesoscale) relevant for phonon scattering makes it possible to increase the dimensionless figure of merit to more than two, which could allow for the recovery of a significant fraction of waste heat with which to produce electricity. | | | | | | | | | | | | Afternoon rain more likely over drier soils ▶ | | | | Christopher M. Taylor, Richard A. M. de Jeu, Françoise Guichard, Phil P. Harris & Wouter A. Dorigo | | | | Analysis of observations on six continents reveals a global preference for afternoon rain to fall on locally drier soils—contrary to the predictions of large-scale climate models, and suggesting that such models may exaggerate the occurrence of droughts. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Brief Communications Arising | | | | | | | | | | | | | | | | | | | | Evan et al. reply ▶ | | | | Amato T. Evan, James P. Kossin, Chul ‘Eddy’ Chung & V. Ramanathan | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Oceanic nitrogen reservoir regulated by plankton diversity and ocean circulation ▶ | | | | Thomas Weber & Curtis Deutsch | | | | Here, the feedback between marine nitrogen fixation and denitrification is shown to yield an oceanic nitrate deficit more than double its observed value in a model with realistic ocean circulation; this discrepancy can be resolved by accounting for diversity in the metabolic N:P requirements of plankton. | | | | | | | | | | | | Afternoon rain more likely over drier soils ▶ | | | | Christopher M. Taylor, Richard A. M. de Jeu, Françoise Guichard, Phil P. Harris & Wouter A. Dorigo | | | | Analysis of observations on six continents reveals a global preference for afternoon rain to fall on locally drier soils—contrary to the predictions of large-scale climate models, and suggesting that such models may exaggerate the occurrence of droughts. | | | | | | | | | | | | | | | | | | | | Brief Communications Arising | | | | | | | | | | | | | | | | | | | | Evan et al. reply ▶ | | | | Amato T. Evan, James P. Kossin, Chul ‘Eddy’ Chung & V. Ramanathan | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
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| | | | | | | | | | | | | | | | Postdocs: A voice for the voiceless ▶ | | | | In its first ten years, the US National Postdoctoral Association has helped to raise the profile of postdocs. But championing their cause still presents challenges. | | | | | | | | | | | | | | | | | | | | | | | | Careers related news & comment | | | | | | | | | | | | | | | |
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