Nature Biotechnology Contents: Volume 30 pp 805 - 896

Advertisement Size: Reduced. Fun: Amplified. Discover a different kind of real-time PCR system, ultra-compact, silent and sleek. The LightCycler® Nano Instrument performs fast and accurate qPCR and HRM for up to 32 samples in tube strips. Run it with a PC and Mac, or use just a USB flash drive. Experience cutting-edge thermal resolution and reproducibility. Light up your lab now! TABLE OF CONTENTS September 2012 Volume 30, Issue 9 In This Issue Editorials News Bioentrepreneur Correspondence Feature News and Views Research Highlights Computational Biology Research Careers and Recruitment Advertisement COMPROMISING WHEN YOU NEED A CUSTOM PANEL FOR TARGETED ENRICHMENT? TargetRich™ custom designs enable you to capture the regions you desire, while delivering the results you need. Your research is too important to compromise.  Click here to see the results and see why others are calling us about TargetRich.  Call us and let us show you how our custom enrichment solutions can be a part of your solution.  Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BioPharma Dealmakers A supplement to Nature Biotechnology and Nature Reviews Drug Discovery This issue covers the partnering strategies of the industry's movers and shakers, the deals that are shaping our industry, the best emerging biotech and academic innovators, and the contract services that support them. Click here to download this issue for FREE! Advertisement Watch Webinar: The Role of Adenine Methylation in Determining the Pathogenicity of a Bacteria Find out how Dr. Eric Schadt, Mt. Sinai Medical Center, and collaborators identified a deadly strain of E. coli from the 2011 outbreak and further characterized it using the unique DNA base modification detection capabilities of single molecule, real-time (SMRT®) sequencing. Advertisement New Partnering Opportunities in Alzheimer's Disease! A comprehensive interactive dashboard from Relay Technology Management Click here for more information on Alzheimer's partnering opportunities.   In This Issue Top In this issue   ppvii - viii doi:10.1038/nbt.2365 Editorials Top Will the floodgates open for gene therapy?   p805 doi:10.1038/nbt.2363 In a matter of days, a momentous event will occur: a gene therapy will, for the first time anywhere in the Western hemisphere, be available commercially with full marketing approval. Further confirmation needed   p806 doi:10.1038/nbt.2335 A new mechanism for independently replicating research findings is one of several changes required to improve the quality of the biomedical literature. News Top First gene therapy nears landmark European market authorization   pp807 - 809 Nuala Moran doi:10.1038/nbt0912-807 US funds vaccine centers for biodefense   p808 Michael Eisenstein doi:10.1038/nbt0912-808 Bayer acquisition spotlights biopesticides   p810 Jim Kling doi:10.1038/nbt0912-810a Regulatory fog lifts on obesity drugs   pp810 - 811 Aaron Bouchie doi:10.1038/nbt0912-810b Amylin's three-party good-bye   p812 Brady Huggett doi:10.1038/nbt0912-812a Industry cautiously welcomes Supreme Court decision on healthcare overhaul   pp812 - 813 Emily Waltz doi:10.1038/nbt0912-812b Compulsory license bandwagon gains momentum   p814 Michael Francisco doi:10.1038/nbt0912-814a Biotechs opt for alternative floatation strategy   p814 Mark Ratner doi:10.1038/nbt0912-814b GSK buys partner Human Genome Sciences   p815 Mark Ratner doi:10.1038/nbt0912-815a India's biosimilar regulations   p815 Killugudi Jayaraman doi:10.1038/nbt0912-815b Myriad's patents redux   p815 Laura DeFrancesco doi:10.1038/nbt0912-815c NIH injects $275 million into undiagnosed diseases and RNA research   p816 Malorye Allison doi:10.1038/nbt0912-816a China's key R&D programs behind schedule   p816 Hepeng Jia doi:10.1038/nbt0912-816b Around the world in a month   p816 doi:10.1038/nbt0912-816c Data Page Drug pipeline: Q212   p817 Laura DeFrancesco doi:10.1038/nbt.2359 News Feature Patient power   pp818 - 820 Jim Kling doi:10.1038/nbt.2360 Patient foundations are not only exploring new funding models but also catalyzing translational research, with notable successes. Jim Kling reports. Advertisement Human and Mouse Exome NGS $798/each, guaranteed coverage RNA-Seq from $798: 20 million guaranteed reads 4-6 weeks, fastest turnaround time in the industry   http://www.otogenetics.com/ Bioentrepreneur Top How much risk are you prepared to take?   pp821 - 824 Mark Van Dyke doi:10.1038/nbt.2330 Correspondence Top To be or not to be transgenic   pp825 - 826 Wayne A Parrott, Joseph M Jez and L Curtis Hannah doi:10.1038/nbt.2347 Broad consent in biobanking   p826 Chris Hempel, Geoffrey Lomax and Steve Peckman doi:10.1038/nbt.2349 An accelerated workflow for untargeted metabolomics using the METLIN database   pp826 - 828 Ralf Tautenhahn, Kevin Cho, Winnie Uritboonthai, Zhengjiang Zhu, Gary J Patti and Gary Siuzdak doi:10.1038/nbt.2348 Successful suppression of a field mosquito population by sustained release of engineered male mosquitoes   pp828 - 830 Angela F Harris, Andrew R McKemey, Derric Nimmo, Zoe Curtis, Isaac Black, Sian A Morgan, Marco Neira Oviedo, Renaud Lacroix, Neil Naish, Neil I Morrison, Amandine Collado, Jessica Stevenson, Sarah Scaife, Tarig Dafa'alla, Guoliang Fu, Caroline Phillips, Andrea Miles, Norzahira Raduan, Nick Kelly, Camilla Beech, Christl A Donnelly, William D Petrie and Luke Alphey doi:10.1038/nbt.2350 Feature Top Patents Teva v. AstraZeneca and secret prior art under 102(g)(2)   pp831 - 833 Sandra Lee and Michael Knierim doi:10.1038/nbt.2353 A recent Federal Circuit decision and the reasoning behind it could have a significant impact on the patentability of other life science inventions, even after changes in the patent law. Recent patent applications in biosensors   p834 doi:10.1038/nbt.2371 News and Views Top Modulating WNT receptor turnover for tissue repair   pp835 - 836 Arie Abo and Hans Clevers doi:10.1038/nbt.2361 New mechanistic insight into the regulation of WNT signaling supports efforts to target this pathway in adult stem cells for regenerative medicine. RNA-mediated programmable DNA cleavage   pp836 - 838 Rodolphe Barrangou doi:10.1038/nbt.2357 Genome engineering has a new tool[mdash]endonucleases involved in bacterial adaptive immunity that can be reprogrammed with customizable small, noncoding RNAs. Silicon dreams of cells into symbols   pp838 - 840 Jeremy Gunawardena doi:10.1038/nbt.2358 Diverse mathematical models combine to create a comprehensive whole-cell computational model of a human pathogen. Biotechnology JOBS of the week Biotechnology (Postdoctoral Scholarship / Associate Scientist / Undergraduate Scholarship / Technician): Brazil FK Biotecnologia Molecular Microbiology Center for Pharmaceutical Biotechnology, University of Illinois at Chicago Biomedical Research Institute of Molecular iology and Biotechnology, Foundation for Research and Technology-Hellas More Science jobs from Biotechnology EVENT 15th European Biotechnology Congress (ECB15) & Biochemistry Symposium (ESBES) September 23-26, 2012 Istanbul, Turkey More science events from Research Highlights Top High-speed imaging in a flow | Membrane fishing for HIV-neutralizing antibodies | Expanding the engineer's toolkit | Photoactive chemical 'restores' sight | mRNA-bound proteome Computational Biology Top Perspective Navigating cancer network attractors for tumor-specific therapy   pp842 - 848 Pau Creixell, Erwin M Schoof, Janine T Erler and Rune Linding doi:10.1038/nbt.2345 Research Top Perspective Lessons from human teratomas to guide development of safe stem cell therapies   pp849 - 857 Justine J Cunningham, Thomas M Ulbright, Martin F Pera and Leendert H J Looijenga doi:10.1038/nbt.2329 Articles Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators   pp858 - 867 Bernd Bodenmiller, Eli R Zunder, Rachel Finck, Tiffany J Chen, Erica S Savig, Robert V Bruggner, Erin F Simonds, Sean C Bendall, Karen Sachs, Peter O Krutzik and Garry P Nolan doi:10.1038/nbt.2317 Mass cytometry can measure up to 34 markers on cells, but samples cannot be multiplexed. Bodenmiller et al. use metal ion tags to facilitate multiplexed mass cytometry analysis of human blood cell samples treated with 27 kinase inhibitors and 12 stimuli across a range of dosages and time points. Combinatorial discovery of polymers resistant to bacterial attachment   pp868 - 875 Andrew L Hook, Chien-Yi Chang, Jing Yang, Jeni Luckett, Alan Cockayne, Steve Atkinson, Ying Mei, Roger Bayston, Derek J Irvine, Robert Langer, Daniel G Anderson, Paul Williams, Martyn C Davies and Morgan R Alexander doi:10.1038/nbt.2316 Bacterial attachment and biofilm formation are problematic for medical devices. Hook et al. present a high-throughput method to find materials that resist bacterial attachment and colonization. Letters Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein   pp876 - 882 Amy P Wong, Christine E Bear, Stephanie Chin, Peter Pasceri, Tadeo O Thompson, Ling-Jun Huan, Felix Ratjen, James Ellis and Janet Rossant doi:10.1038/nbt.2328 Wong et al. differentiate human pluripotent stem cells into mature airway epithelial cells expressing CFTR, a gene involved in cystic fibrosis. Applying the method to induced pluripotent stem cells derived from cystic fibrosis patients provides a renewable source of cells for drug screening. Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens   pp883 - 888 Frank Wegmann, Kate H Gartlan, Ali M Harandi, Sarah A Brinckmann, Margherita Coccia, William R Hillson, Wai Ling Kok, Suzanne Cole, Ling-Pei Ho, Teresa Lambe, Manoj Puthia, Catharina Svanborg, Erin M Scherer, George Krashias, Adam Williams, Joseph N Blattman, Philip D Greenberg, Richard A Flavell, Amin E Moghaddam, Neil C Sheppard and Quentin J Sattentau doi:10.1038/nbt.2344 No mucosal adjuvant formulation is approved for clinical use, even though boosting immunity at sites of pathogen entry should increase the efficacy of nonreplicating vaccines. Wegmann et al. report that polyethyleneimine (PEI) acts as a potent mucosal adjuvant for protein antigens from influenza and herpes simplex virus, protecting mice against otherwise lethal infections. Engineering phosphorus metabolism in plants to produce a dual fertilization and weed control system   pp889 - 893 Damar Lizbeth Lopez-Arredondo and Luis Herrera-Estrella doi:10.1038/nbt.2346 Lopez-Arredondo and Herrera-Estrella produce transgenic plants that express a bacterial phosphite-oxidoreductase gene to enable use of phosphite as a sole phosphorus source. This technology could reduce the amount of non-renewable phosphorus used as fertilizer and control weeds. Careers and Recruitment Top Theory to practice: real-world case-based learning for management degrees   pp894 - 895 Maria Theodosiou, Jean-Philippe Rennard and Arsia Amir-Aslani doi:10.1038/nbt.2362 For scientists looking to break into the biotech industry, scientific knowledge and technical skills are only a partial requirement for success. People People   p896 doi:10.1038/nbt.2372 Top Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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