Nature Reviews Genetics Contents September 2012 Volume 13 Number 9 pp 595-672

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TABLE OF CONTENTS
September 2012 Volume 13 Number 9		Advertisement
Impact Factor 38.075 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Applications of next-generation sequencing Modes of transcriptional regulation Study designs  Featured article: The Notch signalling system: recent insights into the complexity of a conserved pathway K. G. Guruharsha, Mark W. Kankel & Spyros Artavanis-Tsakonas	The New BD FACSJaz™ Cell Sorter Perfectly tuned cell sorting is now available with the new BD FACSJazz. Built on a proven, dependable platform, it may change the way you'll think of cell sorting with ease of operation, affordability, and a benchtop fit. Exceedingly capable performance whether as a soloist or part of your core lab ensemble. bdbiosciences.com/jazz
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Nature Outlook: Diabetes 5% of the world's population are afflicted by either type 1 diabetes, an autoimmune disorder, or type 2 diabetes, largely linked to lifestyle. Nature Outlook: Diabetes examines the latest research into the causes, therapy, prevention and impact of these devastating diseases. Access the Outlook free online for six months. Produced with support from: Eli Lilly and Company
RESEARCH HIGHLIGHTS Top Development: Segmentation by sequestration p595 | doi:10.1038/nrg3307 PDF Development: Triggering meiotic fate p596 | doi:10.1038/nrg3311 PDF Cancer genomics: Chromatin influence on cancer mutation rate p596 | doi:10.1038/nrg3312 PDF Chromatin: Nucleosomal dynamics at centromeres p596 | doi:10.1038/nrg3313 PDF Technology: When two halves are better than one whole p598 | doi:10.1038/nrg3308 PDF Genomics: Personal genome project p599 | doi:10.1038/nrg3309 PDF Splicing: Waiting to be spliced p599 | doi:10.1038/nrg3310 PDF IN BRIEF Plant genomics: Associative transcriptomics | Genomic technology: Recombination maps get personal | Complex traits: Extreme phenotypes assist association studies | Genomic instability: Meta-analysis of aneuploid cell gene expression | Gene-based therapy: RNA therapy for myotonic dystrophy | Genomics: Mitochondrial mutations may explain why women live longer than men | Cancer genetics: Evaluating oncogene cooperativities | DNA methylation: Variation in methylomes of neonatal twins PDF Genetics JOBS of the week Post-doctoral position: Genetics of neuroendocrine tumors Inserm U970 Professorship For Cell Biology And Genetics University of Salzburg Postdoctoral Research Fellow in fish genetics / genomics The Ohio State University South Centers Professorship for Molecular Genetics University of Salzburg, Austria Cancer Genetics Faculty Position Roswell Park Cancer Institute More Science jobs from Genetics EVENT 25th Annual Mouse Molecular Genetics Conference 02.-06.10.12 CA, US More science events from
REVIEWS		Top
Article series: Applications of next-generation sequencing Transforming clinical microbiology with bacterial genome sequencing Xavier Didelot, Rory Bowden, Daniel J. Wilson, Tim E. A. Peto & Derrick W. Crook p601 | doi:10.1038/nrg3226 This Review sets out the emerging potential of next-generation sequencing in the context of clinical microbiology. Using bacterial genome sequencing as an example, the authors discuss the options and challenges for species identification, testing for virulence and drug resistance and monitoring outbreaks. Abstract | Full Text | PDF
Article series: Modes of transcriptional regulation Transcription factors: from enhancer binding to developmental control Francois Spitz & Eileen E. M. Furlong p613 | doi:10.1038/nrg3207 How do transcription factors lead to defined developmental programs? The ways in which transcription factors act at enhancer elements and how enhancer activity is established during development are discussed in this Review, which brings together genetic and genomic evidence. Abstract | Full Text | PDF
The genetic basis of flowering responses to seasonal cues Fernando Andrés & George Coupland p627 | doi:10.1038/nrg3291 Seasonal cues, such as day length and temperature, influence the developmental programme of plants. Recent genetic research has shed light on the pathways that lead to seasonal responses in flowering. The regulation of these pathways in Arabidopsis thaliana, their conservation throughout other species and comparative analysis of annual and perennial plants are considered here. Abstract | Full Text | PDF
Article series: Study designs The continuing value of twin studies in the omics era Jenny van Dongen, P. Eline Slagboom, Harmen H. M. Draisma, Nicholas G. Martin & Dorret I. Boomsma p640 | doi:10.1038/nrg3243 Twin studies have long been used for dissecting the relative contributions of genetics and other factors to various phenotypes. This Review discusses how these traditional studies are now being integrated with modern omics technologies to provide a wide range of biological insights. Abstract | Full Text | PDF | Supplementary information
The Notch signalling system: recent insights into the complexity of a conserved pathway K. G. Guruharsha, Mark W. Kankel & Spyros Artavanis-Tsakonas p654 | doi:10.1038/nrg3272 The Notch signalling network is highly conserved in Metazoa and is crucial for various cell-fate decisions. Focusing on Drosophila melanogaster, this Review summarizes and integrates various recent studies, including large-scale genetic and proteomic screens that have provided a new appreciation of the complexity of Notch signalling. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Article series: Applications of next-generation sequencing Next-generation sequencing data interpretation: enhancing reproducibility and accessibility Anton Nekrutenko & James Taylor p667 | doi:10.1038/nrg3305 There are many different methods and tools available for the analysis of next-generation sequencing data. The challenges towards applying these analysis tools in a transparent and reproducible manner are presented, and a way forward for analysing these data in life sciences research is discussed. Abstract | Full Text | PDF | Supplementary information
Corrigendum: Genetics of osteoporosis from genome-wide association studies: advances and challenges J. Brent Richards, Hou-Feng Zheng & Tim D. Spector p672 | doi:10.1038/nrg3315 Full Text | PDF
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Nature Reviews Genetics ARTICLE SERIES ON DISEASE MECHANISMS Starting August 2012 The articles in this series demonstrate the crucial part genetics plays in furthering our understanding of the basis of disease, from revealing biological pathways to improving knowledge of the relative contributions of various genetic and environmental factors. Follow the Article Series online: www.nature.com/nrg/series/disease
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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